U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PRR36 proline rich 36 [ Homo sapiens (human) ]

Gene ID: 80164, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
PRR36provided by HGNC
Official Full Name
proline rich 36provided by HGNC
Primary source
HGNC:HGNC:26172
See related
Ensembl:ENSG00000183248 AllianceGenome:HGNC:26172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a large protein of unknown function that contains internal regions of low complexity sequence. Alternative splicing results in multiple transcript variants. The transcript structure of the protein-coding variant at this locus is conserved between human and mouse. [provided by RefSeq, Oct 2013]
Expression
Biased expression in brain (RPKM 7.2), prostate (RPKM 1.1) and 4 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PRR36 in Genome Data Viewer
Location:
19p13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (7868719..7874390, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (7869675..7875346, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7933605..7939275, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13901 Neighboring gene exosome component 3 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13902 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9991 Neighboring gene ecotropic viral integration site 5 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7912355-7912856 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7922203-7922988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7926271-7926910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7926911-7927548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7928643-7929351 Neighboring gene Sharpr-MPRA regulatory region 2174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7933728-7934489 Neighboring gene Sharpr-MPRA regulatory region 8899 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7938477-7938993 Neighboring gene LYPLA2 pseudogene 2 Neighboring gene RNA, 5S ribosomal pseudogene 463

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Pellino-2 in nonimmune cells: novel interaction partners and intracellular localization. Cristea I, et al. FEBS Lett, 2021 Dec. PMID 34674267
  2. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Sokolina K, et al. Mol Syst Biol, 2017 Mar 15. PMID 28298427, Free PMC Article
  3. Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. Müller PM, et al. Nat Cell Biol, 2020 Apr. PMID 32203420
  4. Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery. Havugimana PC, et al. Nat Commun, 2022 Jul 13. PMID 35831314, Free PMC Article
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Clone Names

  • FLJ22184

General protein information

Go to the top of the page Help
Preferred Names
proline-rich protein 36

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033809.1 RefSeqGene

    Range
    5052..10723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001190467.2 → NP_001177396.1  proline-rich protein 36

    See identical proteins and their annotated locations for NP_001177396.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AC010336, AL537525, KF459711
    Consensus CDS
    CCDS74276.1
    UniProtKB/Swiss-Prot
    A0A087WZ52, Q9H3X1, Q9H6K5
    Related
    ENSP00000482374.1, ENST00000618550.5
    Conserved Domains (1) summary
    pfam15363
    Location:1303 → 1346
    DUF4596; Domain of unknown function (DUF4596)

RNA

  1. NR_104345.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at an internal exon and lacks an internal segment, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AC010336, BE791180, BX452280

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    7868719..7874390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    7869675..7875346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080403.1: Suppressed sequence

    Description
    NM_001080403.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

  2. NM_025094.1: Suppressed sequence

    Description
    NM_025094.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H6K5.2 GenPept UniProtKB/Swiss-Prot:Q9H6K5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous