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PAQR6 progestin and adipoQ receptor family member 6 [ Homo sapiens (human) ]

Gene ID: 79957, updated on 5-Mar-2024

Summary

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Official Symbol
PAQR6provided by HGNC
Official Full Name
progestin and adipoQ receptor family member 6provided by HGNC
Primary source
HGNC:HGNC:30132
See related
Ensembl:ENSG00000160781 MIM:614579; AllianceGenome:HGNC:30132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRdelta
Summary
Predicted to enable signaling receptor activity. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 24.4), skin (RPKM 3.1) and 2 other tissues See more
Orthologs
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Genomic context

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Location:
1q22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156243320..156248056, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155381777..155386513, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156213111..156217847, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1856 Neighboring gene PMF1-BGLAP readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1422 Neighboring gene polyamine modulated factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1857 Neighboring gene BGLAP promoter region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1424 Neighboring gene Sharpr-MPRA regulatory region 3040 Neighboring gene bone gamma-carboxyglutamate protein Neighboring gene SMG5 nonsense mediated mRNA decay factor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156250697-156251670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1425 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:156252643-156253614 Neighboring gene transmembrane protein 79 Neighboring gene Sharpr-MPRA regulatory regions 9834 and 13552 Neighboring gene glycosylated lysosomal membrane protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PAQR6 Upregulation Is Associated with AR Signaling and Unfavorite Prognosis in Prostate Cancers. Yang M, et al. Biomolecules, 2021 Sep 18. PMID 34572596, Free PMC Article
  2. Characterization, neurosteroid binding and brain distribution of human membrane progesterone receptors δ and {epsilon} (mPRδ and mPR{epsilon}) and mPRδ involvement in neurosteroid inhibition of apoptosis. Pang Y, et al. Endocrinology, 2013 Jan. PMID 23161870, Free PMC Article
  3. Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors. Smith JL, et al. Steroids, 2008 Oct. PMID 18603275, Free PMC Article
  4. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. Huang X, et al. Mol Endocrinol, 2013 Sep. PMID 23864651, Free PMC Article
  5. Identification of genes related to Parkinson's disease using expressed sequence tags. Kim JM, et al. DNA Res, 2006 Dec 31. PMID 17213182

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PAQR6 Upregulation Is Associated with AR Signaling and Unfavorite Prognosis in Prostate Cancers.
    Title: PAQR6 Upregulation Is Associated with AR Signaling and Unfavorite Prognosis in Prostate Cancers.
  2. The results suggest that PAQR6 and PAQR9 (mPRdelta and mPRepsilon) function as mPRs coupled to G proteins and are potential intermediaries of nonclassical antiapoptotic actions of neurosteroids in the central nervous system.
    Title: Characterization, neurosteroid binding and brain distribution of human membrane progesterone receptors δ and {epsilon} (mPRδ and mPR{epsilon}) and mPRδ involvement in neurosteroid inhibition of apoptosis.
  3. PAQR6 is a previously uncharacterized PAQR which is also capable of responding to progesterone.
    Title: Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of hematological and biochemical traits in a Japanese population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22672

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
membrane progestin receptor delta
Names
mPR delta
membrane progesterone P4 receptor delta
membrane progesterone receptor delta
progesterone and adipoQ receptor family member 6
progestin and adipoQ receptor family member VI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272104.2 → NP_001259033.1  membrane progestin receptor delta isoform 2

    See identical proteins and their annotated locations for NP_001259033.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses alternate splice sites at internal exons and initiates translation at an alternate start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has distinct N- and C-termini and is shorter, compared to isoform 1.
    Source sequence(s)
    AA310453, AF455047, AK095197, AK294143, AL135927, BP217276
    Consensus CDS
    CCDS1136.1
    UniProtKB/Swiss-Prot
    B7Z9R9, D3DVB4, D3DVB6, Q5TCK9, Q6PDU0, Q6TCH4, Q7Z4Q7, Q7Z4Q9, Q8N121, Q8N3M2, Q9H621
    UniProtKB/TrEMBL
    Q5TCK7, Q5TCK8
    Conserved Domains (1) summary
    pfam03006
    Location:43 → 272
    HlyIII; Haemolysin-III related

  2. NM_001272105.2 → NP_001259034.1  membrane progestin receptor delta isoform 3

    See identical proteins and their annotated locations for NP_001259034.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, uses alternate splice sites in the coding region and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (3) has distinct N- and C-termini and is shorter, compared to isoform 1.
    Source sequence(s)
    AA310453, AF455047, AK316034, AL135927, DT218672
    Consensus CDS
    CCDS60301.1
    UniProtKB/TrEMBL
    Q5TCK8
    Related
    ENSP00000349474.3, ENST00000356983.7
    Conserved Domains (1) summary
    pfam03006
    Location:40 → 269
    HlyIII; Haemolysin-III related

  3. NM_001272106.2 → NP_001259035.1  membrane progestin receptor delta isoform 4

    See identical proteins and their annotated locations for NP_001259035.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA310453, AK295916, AL135927
    Consensus CDS
    CCDS72946.1
    UniProtKB/TrEMBL
    B4DJ42
    Related
    ENSP00000482685.1, ENST00000612424.4

  4. NM_001272107.2 → NP_001259036.1  membrane progestin receptor delta isoform 5

    See identical proteins and their annotated locations for NP_001259036.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site at an internal exon in the 3' coding region, compared to variant 1. It encodes isoform 5 which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA310453, AF455045, AF455047, AL135927, BP217276
    UniProtKB/TrEMBL
    K9J969
    Related
    ENST00000468632.5
    Conserved Domains (1) summary
    cl03831
    Location:1 → 166
    HlyIII; Haemolysin-III related

  5. NM_001272108.2 → NP_001259037.1  membrane progestin receptor delta isoform 6

    See identical proteins and their annotated locations for NP_001259037.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has multiple differences and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (6) has distinct N- and C-termini and is shorter, compared to isoform 1.
    Source sequence(s)
    AA310453, AF455047, AL135927, BP208594, BP217276
    UniProtKB/Swiss-Prot
    Q6TCH4
    Conserved Domains (1) summary
    cl03831
    Location:59 → 161
    HlyIII; Haemolysin-III related

  6. NM_001272109.2 → NP_001259038.1  membrane progestin receptor delta isoform 7

    See identical proteins and their annotated locations for NP_001259038.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has multiple differences and initiates translation at an alternate start codon, compared to variant 1. Variants 8 through 12 encode the same isoform (7), which has a distinct N-terminus and is shorter, compared to isoform 1.
    Source sequence(s)
    AA310453, AF455046, AF455047, AK316034, AL135927
    Consensus CDS
    CCDS72945.1
    UniProtKB/TrEMBL
    A0A9K3Y7B0, D3DVB5, Q7Z4Q8
    Related
    ENSP00000485607.1, ENST00000623241.3

  7. NM_001272110.2 → NP_001259039.1  membrane progestin receptor delta isoform 7

    See identical proteins and their annotated locations for NP_001259039.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) has multiple differences and initiates translation at an alternate start codon, compared to variant 1. Variants 8 through 12 encode the same isoform (7), which has a distinct N-terminus and is shorter, compared to isoform 1.
    Source sequence(s)
    AA310453, AF455047, AK054682, AL135927
    Consensus CDS
    CCDS72945.1
    UniProtKB/TrEMBL
    A0A9K3Y7B0, D3DVB5, Q7Z4Q8

  8. NM_001272111.2 → NP_001259040.1  membrane progestin receptor delta isoform 7

    See identical proteins and their annotated locations for NP_001259040.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) has multiple differences and initiates translation at an alternate start codon, compared to variant 1. Variants 8 through 12 encode the same isoform (7), which has a distinct N-terminus and is shorter, compared to isoform 1.
    Source sequence(s)
    AA310453, AF455047, AL135927, BI551776, BP208594
    Consensus CDS
    CCDS72945.1
    UniProtKB/TrEMBL
    A0A9K3Y7B0, D3DVB5, Q7Z4Q8

  9. NM_001272112.2 → NP_001259041.1  membrane progestin receptor delta isoform 7

    See identical proteins and their annotated locations for NP_001259041.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) has multiple differences and initiates translation at an alternate start codon, compared to variant 1. Variants 8 through 12 encode the same isoform (7), which has a distinct N-terminus and is shorter, compared to isoform 1.
    Source sequence(s)
    AA310453, AF455046, AK295916, AK316034, AL135927, BI819919
    Consensus CDS
    CCDS72945.1
    UniProtKB/TrEMBL
    A0A9K3Y7B0, D3DVB5, Q7Z4Q8
    Related
    ENSP00000443167.2, ENST00000540423.5

  10. NM_001272113.2 → NP_001259042.1  membrane progestin receptor delta isoform 7

    See identical proteins and their annotated locations for NP_001259042.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) has multiple differences and initiates translation at an alternate start codon, compared to variant 1. Variants 8 through 12 encode the same isoform (7), which has a distinct N-terminus and is shorter, compared to isoform 1.
    Source sequence(s)
    AA310453, AF455047, AL135927, BP217276, BP362806
    Consensus CDS
    CCDS72945.1
    UniProtKB/TrEMBL
    A0A9K3Y7B0, D3DVB5, Q7Z4Q8
    Related
    ENSP00000479864.1, ENST00000613336.4

  11. NM_024897.4 → NP_079173.2  membrane progestin receptor delta isoform 1

    See identical proteins and their annotated locations for NP_079173.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA310453, AK095197, AK295916, AL135927, BP217276
    Consensus CDS
    CCDS1135.1
    UniProtKB/Swiss-Prot
    Q6TCH4
    UniProtKB/TrEMBL
    B4DJ42
    Related
    ENSP00000338330.1, ENST00000335852.6
    Conserved Domains (1) summary
    cl03831
    Location:1 → 150
    HlyIII; Haemolysin-III related

  12. NM_198406.3 → NP_940798.1  membrane progestin receptor delta isoform 2

    See identical proteins and their annotated locations for NP_940798.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites in the 5' UTR and coding region and initiates translation at an alternate start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has distinct N- and C-termini and is shorter, compared to isoform 1.
    Source sequence(s)
    AA310453, AF455047, AK026325, AL135927, BC058509, BP217276
    Consensus CDS
    CCDS1136.1
    UniProtKB/Swiss-Prot
    B7Z9R9, D3DVB4, D3DVB6, Q5TCK9, Q6PDU0, Q6TCH4, Q7Z4Q7, Q7Z4Q9, Q8N121, Q8N3M2, Q9H621
    UniProtKB/TrEMBL
    Q5TCK7, Q5TCK8
    Related
    ENSP00000292291.5, ENST00000292291.10
    Conserved Domains (1) summary
    pfam03006
    Location:43 → 272
    HlyIII; Haemolysin-III related

RNA

  1. NR_073610.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) uses multiple alternate splice sites, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA310453, AF455047, AL135927, BC058509, BP217276
    Related
    ENST00000368270.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    156243320..156248056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    155381777..155386513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6TCH4.2 GenPept UniProtKB/Swiss-Prot:Q6TCH4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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