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NAA40 N-alpha-acetyltransferase 40, NatD catalytic subunit [ Homo sapiens (human) ]

Gene ID: 79829, updated on 3-Apr-2024

Summary

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Official Symbol
NAA40provided by HGNC
Official Full Name
N-alpha-acetyltransferase 40, NatD catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:25845
See related
Ensembl:ENSG00000110583 MIM:619999; AllianceGenome:HGNC:25845
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NatD; NAT11; PATT1; hNatD
Summary
Enables H2A histone acetyltransferase activity; H4 histone acetyltransferase activity; and peptide-serine-N-acetyltransferase activity. Involved in N-terminal protein amino acid acetylation; histone H2A acetylation; and histone H4 acetylation. Located in centriolar satellite; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 9.3), spleen (RPKM 7.5) and 25 other tissues See more
Orthologs
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Genomic context

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See NAA40 in Genome Data Viewer
Location:
11q13.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63939002..63957319)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63928708..63947014)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63706474..63724791)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene microtubule affinity regulating kinase 2 Neighboring gene tRNA-Arg (anticodon CCT) 9-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63670286-63671098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63674933-63675606 Neighboring gene Sharpr-MPRA regulatory region 844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63682139-63683091 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63683713-63684376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3449 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3450 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63687688-63688350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63688351-63689011 Neighboring gene REST corepressor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63705477-63705977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4879 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:63706395-63706580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63712515-63713444 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63728699-63729256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4880 Neighboring gene RNA, U6 small nuclear 45, pseudogene Neighboring gene cytochrome c oxidase subunit 8A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Effects of Oncohistone Mutations and PTM Crosstalk on the N-Terminal Acetylation Activities of NatD. Ho YH, et al. ACS Chem Biol, 2023 Apr 21. PMID 35044762,
  2. NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression. Demetriadou C, et al. Cell Death Dis, 2019 Mar 11. PMID 30858358, Free PMC Article
  3. Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway. Pavlou D, et al. Apoptosis, 2016 Mar. PMID 26666750, Free PMC Article
  4. Structure of Patt1 human proapoptotic histone acetyltransferase. Jędrzejewski RP, et al. J Mol Model, 2013 Dec. PMID 24248912, Free PMC Article
  5. The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4. Hole K, et al. PLoS One, 2011. PMID 21935442, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of Oncohistone Mutations and PTM Crosstalk on the N-Terminal Acetylation Activities of NatD.
    Title: Effects of Oncohistone Mutations and PTM Crosstalk on the N-Terminal Acetylation Activities of NatD.
  2. The findings strengthen the importance of NAA40 to maintain colorectal cancer cell growth. We show that NAA40 oncogenic properties stimulate the global levels of H4R3me2s by transcriptionally activating PRMT5 methyltransferase which in turn modulates the expression of key downstream cancer-related genes.
    Title: NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression.
  3. NatD-mediated acetylation of histone H4 serine 1 competes with phosphorylation by CK2alpha at the same residue, leading to the upregulation of Slug and lung cancer progression.
    Title: NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression.
  4. findings reveal an anti-apoptotic role for Naa40 and exhibit its potential as a therapeutic target in colorectal cancers.
    Title: Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway.
  5. The knowledge of detailed molecular architecture of Patt1 is not only the key to understanding its mechanistic functional properties but it also opens the possibility of rational drug and protein design experiments
    Title: Structure of Patt1 human proapoptotic histone acetyltransferase.
  6. Results strongly suggest that human Naa40p/NatD is conserved from yeast. Thus, the NATs of all classes of N-terminally acetylated proteins in humans now appear to be accounted for.
    Title: The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4.
  7. a novel protein acetyltransferase Patt1 might be involved in the development of hepatocellular carcinoma
    Title: Patt1, a novel protein acetyltransferase that is highly expressed in liver and downregulated in hepatocellular carcinoma, enhances apoptosis of hepatoma cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13848

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone H2A acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H2A acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H4 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H4 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide-serine-alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-serine-alpha-N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
N-alpha-acetyltransferase 40
Names
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog
N-acetyltransferase 11 (GCN5-related, putative)
N-alpha acetyl transferase 40
N-alpha-acetyltransferase D
natD catalytic subunit
protein acetyltransferase 1
NP_001287729.1
NP_079047.2
XP_006718752.1
XP_011543556.2
XP_047283566.1
XP_054225961.1
XP_054225962.1
XP_054225963.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300800.1 → NP_001287729.1  N-alpha-acetyltransferase 40 isoform 2

    See identical proteins and their annotated locations for NP_001287729.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AP003780, BC041617, DC307984, HY009487
    Consensus CDS
    CCDS73311.1
    UniProtKB/TrEMBL
    F2YHM7
    Related
    ENSP00000442055.1, ENST00000542163.1
    Conserved Domains (1) summary
    pfam00583
    Location:59 → 167
    Acetyltransf_1; Acetyltransferase (GNAT) family

  2. NM_024771.4 → NP_079047.2  N-alpha-acetyltransferase 40 isoform 1

    See identical proteins and their annotated locations for NP_079047.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AP003780
    Consensus CDS
    CCDS8053.1
    UniProtKB/Swiss-Prot
    B4DR03, B4DU10, Q5HYL5, Q86UY6, Q9H897
    UniProtKB/TrEMBL
    F2YHM7
    Related
    ENSP00000367024.4, ENST00000377793.9
    Conserved Domains (1) summary
    pfam00583
    Location:80 → 188
    Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    63939002..63957319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545254.3 → XP_011543556.2  N-alpha-acetyltransferase 40 isoform X1

  2. XM_006718689.4 → XP_006718752.1  N-alpha-acetyltransferase 40 isoform X3

    UniProtKB/TrEMBL
    F2YHM7
    Conserved Domains (1) summary
    pfam00583
    Location:117 → 157
    Acetyltransf_1; Acetyltransferase (GNAT) family

  3. XM_047427610.1 → XP_047283566.1  N-alpha-acetyltransferase 40 isoform X2

    Related
    ENST00000338447.10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    63928708..63947014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369986.1 → XP_054225961.1  N-alpha-acetyltransferase 40 isoform X1

  2. XM_054369988.1 → XP_054225963.1  N-alpha-acetyltransferase 40 isoform X3

  3. XM_054369987.1 → XP_054225962.1  N-alpha-acetyltransferase 40 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86UY6.1 GenPept UniProtKB/Swiss-Prot:Q86UY6

Gene LinkOut

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