These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

1. NG_011776.1 RefSeqGene

   Range

   5014..222136

   Download

   GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. NM_001145527.2 → NP_001138999.1  histone-lysine N-methyltransferase EHMT1 isoform 2

   See identical proteins and their annotated locations for NP_001138999.1

   Status: REVIEWED

   Description

   Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.

   Source sequence(s)

   AB028932, BC047504, BM681619

   Consensus CDS

   CCDS56595.1

   UniProtKB/Swiss-Prot

   Q9H9B1

   Related

   ENSP00000417328.1, ENST00000462484.5

   Conserved Domains (3) summary

   cd00204
   Location:742 → 796

   ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

   pfam13637
   Location:742 → 793

   Ank_4; Ankyrin repeats (many copies)

   sd00045
   Location:742 → 768

   ANK; ANK repeat [structural motif]

2. NM_001354259.2 → NP_001341188.1  histone-lysine N-methyltransferase EHMT1 isoform 3

   Status: REVIEWED

   Description

   Transcript Variant: This variant (3) lacks an exon in the 5' region and differs in the 3' exon structure compared to variant 1. It initiates translation at a downstream start codon. The encoded isoform (3) has a shorter N-terminus and distinct C-terminus compared to isoform 1.

   Source sequence(s)

   AK022941, AL590627, AL611925, BC047504

   Conserved Domains (2) summary

   cd00204
   Location:711 → 802

   ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

   sd00045
   Location:743 → 772

   ANK; ANK repeat [structural motif]

3. NM_001354263.2 → NP_001341192.1  histone-lysine N-methyltransferase EHMT1 isoform 4

   Status: REVIEWED

   Description

   Transcript Variant: This variant (4) uses an alternate splice site compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

   Source sequence(s)

   AL365502, AL590627, AL611925

   Conserved Domains (5) summary

   smart00317
   Location:1119 → 1241

   SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

   cd00204
   Location:793 → 919

   ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

   sd00045
   Location:798 → 829

   ANK; ANK repeat [structural motif]

   pfam05033
   Location:1007 → 1111

   Pre-SET; Pre-SET motif

   cl26073
   Location:740 → 999

   Ank_2; Ankyrin repeats (3 copies)

4. NM_001354611.2 → NP_001341540.1  histone-lysine N-methyltransferase EHMT1 isoform 5

   Status: REVIEWED

   Description

   Transcript Variant: This variant (5) lacks multiple 3' exons and contains an alternate 3' coding region and 3' UTR compared to variant 1. The encoded isoform (5) has a shorter, distinct C-terminus compared to isoform 1.

   Source sequence(s)

   AL365502, AL590627

   Consensus CDS

   CCDS87721.1

   UniProtKB/TrEMBL

   A0A1B0GUD1, A0A1B0GVZ8

   Related

   ENSP00000490056.1, ENST00000629335.2

5. NM_001354612.2 → NP_001341541.1  histone-lysine N-methyltransferase EHMT1 isoform 6

   Status: REVIEWED

   Description

   Transcript Variant: This variant (6) lacks an exon in the 5' region, initiates translation at a downstream start codon and differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (6) has a shorter N-terminus and distinct C-terminus compared to isoform 1.

   Source sequence(s)

   AL365502, AL590627

   UniProtKB/TrEMBL

   A0A1B0GVZ8

   Related

   ENSP00000485900.1, ENST00000626066.2

6. NM_024757.5 → NP_079033.4  histone-lysine N-methyltransferase EHMT1 isoform 1

   See identical proteins and their annotated locations for NP_079033.4

   Status: REVIEWED

   Description

   Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

   Source sequence(s)

   AB028932, BC011608, BC047504, CA426038

   Consensus CDS

   CCDS7050.2

   UniProtKB/Swiss-Prot

   B1AQ58, B1AQ59, Q86X08, Q8TCN7, Q96F53, Q96JF1, Q96KH4, Q9H9B1

   Related

   ENSP00000417980.1, ENST00000460843.6

   Conserved Domains (4) summary

   sd00045
   Location:805 → 836

   ANK; ANK repeat [structural motif]

   cd10535
   Location:1036 → 1266

   SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

   cd20905
   Location:514 → 644

   EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2

   pfam12796
   Location:810 → 903

   Ank_2; Ankyrin repeats (3 copies)

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCh38.p14 Primary Assembly

Genomic

1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

   Range

   137619005..137836127

   Download

   GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. XM_047423872.1 → XP_047279828.1  histone-lysine N-methyltransferase EHMT1 isoform X3

2. XM_047423875.1 → XP_047279831.1  histone-lysine N-methyltransferase EHMT1 isoform X8

3. XM_047423878.1 → XP_047279834.1  histone-lysine N-methyltransferase EHMT1 isoform X10

   UniProtKB/TrEMBL

   A0A1B0GV09

4. XM_005266110.2 → XP_005266167.1  histone-lysine N-methyltransferase EHMT1 isoform X10

   See identical proteins and their annotated locations for XP_005266167.1

   UniProtKB/TrEMBL

   A0A1B0GV09

   Conserved Domains (6) summary

   smart00248
   Location:741 → 769

   ANK; ankyrin repeats

   smart00317
   Location:1095 → 1217

   SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

   cd00204
   Location:769 → 895

   ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

   pfam05033
   Location:983 → 1087

   Pre-SET; Pre-SET motif

   pfam12796
   Location:779 → 872

   Ank_2; Ankyrin repeats (3 copies)

   sd00045
   Location:774 → 805

   ANK; ANK repeat [structural motif]

5. XM_047423883.1 → XP_047279839.1  histone-lysine N-methyltransferase EHMT1 isoform X15

6. XM_047423881.1 → XP_047279837.1  histone-lysine N-methyltransferase EHMT1 isoform X13

7. XM_017015138.2 → XP_016870627.1  histone-lysine N-methyltransferase EHMT1 isoform X11

8. XM_047423884.1 → XP_047279840.1  histone-lysine N-methyltransferase EHMT1 isoform X16

9. XM_047423882.1 → XP_047279838.1  histone-lysine N-methyltransferase EHMT1 isoform X14

10. XM_047423885.1 → XP_047279841.1  histone-lysine N-methyltransferase EHMT1 isoform X17

11. XM_024447678.2 → XP_024303446.2  histone-lysine N-methyltransferase EHMT1 isoform X19

12. XM_047423886.1 → XP_047279842.1  histone-lysine N-methyltransferase EHMT1 isoform X20

13. XM_047423888.1 → XP_047279844.1  histone-lysine N-methyltransferase EHMT1 isoform X22

14. XM_047423887.1 → XP_047279843.1  histone-lysine N-methyltransferase EHMT1 isoform X21

    Related

    ENSP00000489961.1, ENST00000636027.1

15. XM_047423889.1 → XP_047279845.1  histone-lysine N-methyltransferase EHMT1 isoform X23

16. XM_011519022.4 → XP_011517324.1  histone-lysine N-methyltransferase EHMT1 isoform X2

    Conserved Domains (6) summary

    smart00248
    Location:774 → 802

    ANK; ankyrin repeats

    smart00317
    Location:1128 → 1250

    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    cd00204
    Location:802 → 928

    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

    pfam05033
    Location:1016 → 1120

    Pre-SET; Pre-SET motif

    pfam12796
    Location:812 → 905

    Ank_2; Ankyrin repeats (3 copies)

    sd00045
    Location:807 → 838

    ANK; ANK repeat [structural motif]

17. XM_017015134.2 → XP_016870623.1  histone-lysine N-methyltransferase EHMT1 isoform X5

18. XM_047423873.1 → XP_047279829.1  histone-lysine N-methyltransferase EHMT1 isoform X6

19. XM_047423879.1 → XP_047279835.1  histone-lysine N-methyltransferase EHMT1 isoform X11

20. XM_011519021.4 → XP_011517323.1  histone-lysine N-methyltransferase EHMT1 isoform X1

    Conserved Domains (4) summary

    COG0666
    Location:765 → 932

    ANKYR; Ankyrin repeat [Signal transduction mechanisms]

    sd00045
    Location:808 → 839

    ANK; ANK repeat [structural motif]

    pfam13637
    Location:912 → 962

    Ank_4; Ankyrin repeats (many copies)

    cd10535
    Location:1039 → 1269

    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

21. XM_047423880.1 → XP_047279836.1  histone-lysine N-methyltransferase EHMT1 isoform X12

22. XM_047423874.1 → XP_047279830.1  histone-lysine N-methyltransferase EHMT1 isoform X7

23. XM_011519023.4 → XP_011517325.1  histone-lysine N-methyltransferase EHMT1 isoform X4

    Conserved Domains (6) summary

    smart00248
    Location:768 → 796

    ANK; ankyrin repeats

    smart00317
    Location:1122 → 1244

    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    cd00204
    Location:796 → 922

    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

    pfam05033
    Location:1010 → 1114

    Pre-SET; Pre-SET motif

    pfam12796
    Location:806 → 899

    Ank_2; Ankyrin repeats (3 copies)

    sd00045
    Location:801 → 832

    ANK; ANK repeat [structural motif]

24. XM_047423876.1 → XP_047279832.1  histone-lysine N-methyltransferase EHMT1 isoform X9

25. XM_047423877.1 → XP_047279833.1  histone-lysine N-methyltransferase EHMT1 isoform X10

    UniProtKB/TrEMBL

    A0A1B0GV09

    Related

    ENSP00000490328.1, ENST00000637161.1

26. XM_024447677.2 → XP_024303445.1  histone-lysine N-methyltransferase EHMT1 isoform X18

    Conserved Domains (5) summary

    smart00317
    Location:834 → 956

    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    cd00204
    Location:508 → 634

    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

    sd00045
    Location:513 → 544

    ANK; ANK repeat [structural motif]

    pfam05033
    Location:722 → 826

    Pre-SET; Pre-SET motif

    pfam12796
    Location:450 → 544

    Ank_2; Ankyrin repeats (3 copies)

27. XM_011519029.4 → XP_011517331.1  histone-lysine N-methyltransferase EHMT1 isoform X24

    UniProtKB/TrEMBL

    A0A0C4DGF8

    Conserved Domains (6) summary

    smart00248
    Location:249 → 277

    ANK; ankyrin repeats

    smart00317
    Location:603 → 725

    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    cd00204
    Location:277 → 403

    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

    pfam05033
    Location:491 → 595

    Pre-SET; Pre-SET motif

    pfam12796
    Location:287 → 380

    Ank_2; Ankyrin repeats (3 copies)

    sd00045
    Location:282 → 313

    ANK; ANK repeat [structural motif]

28. XM_011519030.4 → XP_011517332.1  histone-lysine N-methyltransferase EHMT1 isoform X25

    Conserved Domains (7) summary

    smart00248
    Location:199 → 228

    ANK; ankyrin repeats

    smart00317
    Location:387 → 509

    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    cd00204
    Location:61 → 187

    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

    pfam05033
    Location:275 → 379

    Pre-SET; Pre-SET motif

    pfam12796
    Location:71 → 164

    Ank_2; Ankyrin repeats (3 copies)

    pfam13637
    Location:54 → 87

    Ank_4; Ankyrin repeats (many copies)

    sd00045
    Location:66 → 97

    ANK; ANK repeat [structural motif]

29. XM_047423890.1 → XP_047279846.1  histone-lysine N-methyltransferase EHMT1 isoform X26

30. XM_011519031.2 → XP_011517333.1  histone-lysine N-methyltransferase EHMT1 isoform X26

    See identical proteins and their annotated locations for XP_011517333.1

    Conserved Domains (5) summary

    smart00317
    Location:316 → 438

    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    cd00204
    Location:23 → 149

    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

    pfam05033
    Location:204 → 308

    Pre-SET; Pre-SET motif

    pfam12796
    Location:1 → 93

    Ank_2; Ankyrin repeats (3 copies)

    sd00045
    Location:28 → 60

    ANK; ANK repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

1. NC_060933.1 Alternate T2T-CHM13v2.0

   Range

   149870687..150093989

   Download

   GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. XM_054363815.1 → XP_054219790.1  histone-lysine N-methyltransferase EHMT1 isoform X3

2. XM_054363823.1 → XP_054219798.1  histone-lysine N-methyltransferase EHMT1 isoform X8

3. XM_054363828.1 → XP_054219803.1  histone-lysine N-methyltransferase EHMT1 isoform X10

   UniProtKB/TrEMBL

   A0A1B0GV09

4. XM_054363829.1 → XP_054219804.1  histone-lysine N-methyltransferase EHMT1 isoform X31

5. XM_054363819.1 → XP_054219794.1  histone-lysine N-methyltransferase EHMT1 isoform X27

6. XM_054363835.1 → XP_054219810.1  histone-lysine N-methyltransferase EHMT1 isoform X33

7. XM_054363832.1 → XP_054219807.1  histone-lysine N-methyltransferase EHMT1 isoform X32

8. XM_054363820.1 → XP_054219795.1  histone-lysine N-methyltransferase EHMT1 isoform X28

9. XM_054363837.1 → XP_054219812.1  histone-lysine N-methyltransferase EHMT1 isoform X34

10. XM_054363825.1 → XP_054219800.1  histone-lysine N-methyltransferase EHMT1 isoform X10

    UniProtKB/TrEMBL

    A0A1B0GV09

11. XM_054363838.1 → XP_054219813.1  histone-lysine N-methyltransferase EHMT1 isoform X15

12. XM_054363834.1 → XP_054219809.1  histone-lysine N-methyltransferase EHMT1 isoform X13

13. XM_054363831.1 → XP_054219806.1  histone-lysine N-methyltransferase EHMT1 isoform X11

14. XM_054363839.1 → XP_054219814.1  histone-lysine N-methyltransferase EHMT1 isoform X16

15. XM_054363836.1 → XP_054219811.1  histone-lysine N-methyltransferase EHMT1 isoform X14

16. XM_054363840.1 → XP_054219815.1  histone-lysine N-methyltransferase EHMT1 isoform X17

17. XM_054363851.1 → XP_054219826.1  histone-lysine N-methyltransferase EHMT1 isoform X40

18. XM_054363848.1 → XP_054219823.1  histone-lysine N-methyltransferase EHMT1 isoform X39

19. XM_054363850.1 → XP_054219825.1  histone-lysine N-methyltransferase EHMT1 isoform X22

20. XM_054363852.1 → XP_054219827.1  histone-lysine N-methyltransferase EHMT1 isoform X23

21. XM_054363842.1 → XP_054219817.1  histone-lysine N-methyltransferase EHMT1 isoform X19

22. XM_054363844.1 → XP_054219819.1  histone-lysine N-methyltransferase EHMT1 isoform X36

23. XM_054363843.1 → XP_054219818.1  histone-lysine N-methyltransferase EHMT1 isoform X35

24. XM_054363845.1 → XP_054219820.1  histone-lysine N-methyltransferase EHMT1 isoform X37

25. XM_054363847.1 → XP_054219822.1  histone-lysine N-methyltransferase EHMT1 isoform X20

26. XM_054363849.1 → XP_054219824.1  histone-lysine N-methyltransferase EHMT1 isoform X21

27. XM_054363846.1 → XP_054219821.1  histone-lysine N-methyltransferase EHMT1 isoform X38

28. XM_054363853.1 → XP_054219828.1  histone-lysine N-methyltransferase EHMT1 isoform X41

29. XM_054363814.1 → XP_054219789.1  histone-lysine N-methyltransferase EHMT1 isoform X2

30. XM_054363822.1 → XP_054219797.1  histone-lysine N-methyltransferase EHMT1 isoform X29

31. XM_054363817.1 → XP_054219792.1  histone-lysine N-methyltransferase EHMT1 isoform X5

32. XM_054363826.1 → XP_054219801.1  histone-lysine N-methyltransferase EHMT1 isoform X30

33. XM_054363818.1 → XP_054219793.1  histone-lysine N-methyltransferase EHMT1 isoform X6

34. XM_054363830.1 → XP_054219805.1  histone-lysine N-methyltransferase EHMT1 isoform X11

35. XM_054363833.1 → XP_054219808.1  histone-lysine N-methyltransferase EHMT1 isoform X12

36. XM_054363821.1 → XP_054219796.1  histone-lysine N-methyltransferase EHMT1 isoform X7

37. XM_054363813.1 → XP_054219788.1  histone-lysine N-methyltransferase EHMT1 isoform X1

38. XM_054363816.1 → XP_054219791.1  histone-lysine N-methyltransferase EHMT1 isoform X4

39. XM_054363824.1 → XP_054219799.1  histone-lysine N-methyltransferase EHMT1 isoform X9

40. XM_054363827.1 → XP_054219802.1  histone-lysine N-methyltransferase EHMT1 isoform X10

    UniProtKB/TrEMBL

    A0A1B0GV09

41. XM_054363841.1 → XP_054219816.1  histone-lysine N-methyltransferase EHMT1 isoform X18

42. XM_054363854.1 → XP_054219829.1  histone-lysine N-methyltransferase EHMT1 isoform X24

43. XM_054363855.1 → XP_054219830.1  histone-lysine N-methyltransferase EHMT1 isoform X25

44. XM_054363856.1 → XP_054219831.1  histone-lysine N-methyltransferase EHMT1 isoform X26

The following Reference Sequences have been suppressed. Explain

These RefSeqs were suppressed for the cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related sequence links, or BLAST links (BLink), but may still be retrieved by clicking on their accession.version below.

1. NM_001039765.1: Suppressed sequence

   Description

   NM_001039765.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.