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ZYG11B zyg-11 family member B, cell cycle regulator [ Homo sapiens (human) ]

Gene ID: 79699, updated on 3-Apr-2024

Summary

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Official Symbol
ZYG11Bprovided by HGNC
Official Full Name
zyg-11 family member B, cell cycle regulatorprovided by HGNC
Primary source
HGNC:HGNC:25820
See related
Ensembl:ENSG00000162378 MIM:618673; AllianceGenome:HGNC:25820
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZYG11
Summary
Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 12.1), thyroid (RPKM 8.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1p32.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (52726453..52827336)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (52607957..52708870)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (53192125..53293008)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 pseudogene 3 Neighboring gene RNA, 7SL, cytoplasmic 62, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 898 Neighboring gene RNA, U2 small nuclear 30, pseudogene Neighboring gene ribosomal protein S13 pseudogene 2 Neighboring gene RNA, U6 small nuclear 969, pseudogene Neighboring gene Sharpr-MPRA regulatory region 11599 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:53297677-53298444 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53301449-53302130 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53302131-53302812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 899 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53309013-53309606 Neighboring gene zyg-11 family member A, cell cycle regulator Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53334860-53335744 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53335745-53336627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53370741-53371532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53372219-53372718 Neighboring gene Sharpr-MPRA regulatory region 4702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53377381-53377881 Neighboring gene enoyl-CoA hydratase domain containing 2 Neighboring gene translation machinery-associated protein 7-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53387115-53387797

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A close shave: How SARS-CoV-2 induces the loss of cilia. Fonseca BF, et al. J Cell Biol, 2022 Jul 4. PMID 35695891, Free PMC Article
  2. Structural insights into ORF10 recognition by ZYG11B. Zhang B, et al. Biochem Biophys Res Commun, 2022 Aug 6. PMID 35636250, Free PMC Article
  3. SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity. Wang L, et al. J Cell Biol, 2022 Jul 4. PMID 35674692, Free PMC Article
  4. ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection. Mena EL, et al. Proc Natl Acad Sci U S A, 2021 Apr 27. PMID 33827988, Free PMC Article
  5. A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation. Timms RT, et al. Science, 2019 Jul 5. PMID 31273098, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA LINC01871 sponging miR-142-3p to modulate ZYG11B promotes the chemoresistance of colorectal cancer cells by inducing autophagy.
    Title: LncRNA LINC01871 sponging miR-142-3p to modulate ZYG11B promotes the chemoresistance of colorectal cancer cells by inducing autophagy.
  2. Structural insights into ORF10 recognition by ZYG11B.
    Title: Structural insights into ORF10 recognition by ZYG11B.
  3. A close shave: How SARS-CoV-2 induces the loss of cilia.
    Title: A close shave: How SARS-CoV-2 induces the loss of cilia.
  4. Molecular basis for recognition of Gly/N-degrons by CRL2(ZYG11B) and CRL2(ZER1).
    Title: Molecular basis for recognition of Gly/N-degrons by CRL2(ZYG11B) and CRL2(ZER1).
  5. Functional and genetic analyses of ZYG11B provide evidences for its involvement in OAVS.
    Title: Functional and genetic analyses of ZYG11B provide evidences for its involvement in OAVS.
  6. ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.
    Title: ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.
  7. the ubiquitin ligase CRL2(ZYG-11) redundantly targets the degradation of cyclin B1 in Caenorhabditis elegans and human cells.
    Title: The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13456

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein quality control for misfolded or incompletely synthesized proteins IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein zyg-11 homolog B
Names
zyg-11 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024646.3 → NP_078922.1  protein zyg-11 homolog B

    See identical proteins and their annotated locations for NP_078922.1

    Status: VALIDATED

    Source sequence(s)
    AB051517, AC099784, AK296460, AL139255
    Consensus CDS
    CCDS30717.1
    UniProtKB/Swiss-Prot
    Q8N2X3, Q9C0D3, Q9H8L8
    UniProtKB/TrEMBL
    B3KTI5
    Related
    ENSP00000294353.6, ENST00000294353.7
    Conserved Domains (2) summary
    sd00034
    Location:188 → 213
    LRR_AMN1; leucine-rich repeat [structural motif]
    NF033190
    Location:143 → 248
    inl_like_NEAT_1; NEAT domain-containing leucine-rich repeat protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    52726453..52827336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002336.3 → XP_016857825.1  protein zyg-11 homolog B isoform X2

    UniProtKB/TrEMBL
    A8DPD7
    Related
    ENSP00000441315.1, ENST00000545132.5
    Conserved Domains (1) summary
    sd00034
    Location:188 → 213
    LRR_AMN1; leucine-rich repeat [structural motif]

  2. XM_006710898.5 → XP_006710961.1  protein zyg-11 homolog B isoform X1

    UniProtKB/TrEMBL
    B3KTI5
    Conserved Domains (3) summary
    cd00020
    Location:489 → 607
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    cd00116
    Location:173 → 295
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:184 → 209
    LRR_AMN1; leucine-rich repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    52607957..52708870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338747.1 → XP_054194722.1  protein zyg-11 homolog B isoform X2

    UniProtKB/TrEMBL
    A8DPD7

  2. XM_054338746.1 → XP_054194721.1  protein zyg-11 homolog B isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C0D3.2 GenPept UniProtKB/Swiss-Prot:Q9C0D3

Gene LinkOut

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