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QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 [ Homo sapiens (human) ]

Gene ID: 79691, updated on 5-Mar-2024

Summary

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Official Symbol
QTRT2provided by HGNC
Official Full Name
queuine tRNA-ribosyltransferase accessory subunit 2provided by HGNC
Primary source
HGNC:HGNC:25771
See related
Ensembl:ENSG00000151576 AllianceGenome:HGNC:25771
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QTRTD1
Summary
This gene encodes a subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine, and tyrosine. The encoded protein may play a role in the queuosine 5'-monophosphate salvage pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in lymph node (RPKM 5.0), spleen (RPKM 4.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
3q13.31
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (114056737..114088422)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (116778012..116809687)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (113775584..113807269)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20265 Neighboring gene ATP5PB pseudogene 8 Neighboring gene uncharacterized LOC105374048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20267 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:113777633-113778132 Neighboring gene NANOG hESC enhancer GRCh37_chr3:113829766-113830267 Neighboring gene H2B histone pseudogene 3 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:113871254-113871787 Neighboring gene dopamine receptor D3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:113873145-113873654 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:113873655-113874164

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Evolution of eukaryal tRNA-guanine transglycosylase: insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine transglycosylases. Chen YC, et al. Nucleic Acids Res, 2011 Apr. PMID 21131277, Free PMC Article
  2. Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure. Chen YC, et al. RNA, 2010 May. PMID 20354154, Free PMC Article
  3. Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase. Boland C, et al. J Biol Chem, 2009 Jul 3. PMID 19414587, Free PMC Article
  4. An integrative method for scoring candidate genes from association studies: application to warfarin dosing. Tatonetti NP, et al. BMC Bioinformatics, 2010 Oct 28. PMID 21044367, Free PMC Article
  5. Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. Zhao C, et al. Proc Natl Acad Sci U S A, 2005 Jul 19. PMID 16009940, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: An integrative method for scoring candidate genes from association studies: application to warfarin dosing.
  2. TGT is composed of a catalytic subunit, QTRT1, and QTRTD1, not USP14. QTRTD1 has been implicated as the salvage enzyme that generates free queuine from QMP.
    Title: Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12960

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA-guanosine(34) queuine transglycosylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA-guanine transglycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA-guanine transglycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial outer membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of transferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
queuine tRNA-ribosyltransferase accessory subunit 2
Names
queuine tRNA-ribosyltransferase domain containing 1
NP_001243764.1
NP_001243765.1
NP_001243766.1
NP_078914.1
XP_047304889.1
XP_047304890.1
XP_047304891.1
XP_047304892.1
XP_054203857.1
XP_054203858.1
XP_054203859.1
XP_054203860.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256835.2 → NP_001243764.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' region and initiates translation at an upstream start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    BC034559, BC039265, DC400836
    Consensus CDS
    CCDS58844.1
    UniProtKB/Swiss-Prot
    Q9H974
    Related
    ENSP00000420682.1, ENST00000485050.5
    Conserved Domains (1) summary
    pfam01702
    Location:146 → 420
    TGT; Queuine tRNA-ribosyltransferase

  2. NM_001256836.2 → NP_001243765.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 3

    See identical proteins and their annotated locations for NP_001243765.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks four consecutive internal exons and initiates translation at an upstream start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK296938, BC034559, BC039265, DC400836
    Consensus CDS
    CCDS58845.1
    UniProtKB/Swiss-Prot
    Q9H974
    Related
    ENSP00000419169.1, ENST00000493014.1
    Conserved Domains (1) summary
    pfam01702
    Location:28 → 302
    TGT; Queuine tRNA-ribosyltransferase

  3. NM_001256837.2 → NP_001243766.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 4

    See identical proteins and their annotated locations for NP_001243766.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two internal exons, uses an alternate splice site and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK299313, BC034559, BC039265, DC400836
    Consensus CDS
    CCDS58846.1
    UniProtKB/Swiss-Prot
    Q9H974
    Related
    ENSP00000418056.1, ENST00000479882.5
    Conserved Domains (1) summary
    pfam01702
    Location:11 → 285
    TGT; Queuine tRNA-ribosyltransferase

  4. NM_024638.4 → NP_078914.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_078914.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    BC034559, BC039265, DC400836
    Consensus CDS
    CCDS33828.1
    UniProtKB/Swiss-Prot
    A6NGE9, B7Z472, B7Z5R2, J3KR78, Q6IA59, Q9H974
    Related
    ENSP00000281273.4, ENST00000281273.8
    Conserved Domains (1) summary
    pfam01702
    Location:13 → 413
    TGT; Queuine tRNA-ribosyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    114056737..114088422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448934.1 → XP_047304890.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X2

  2. XM_047448936.1 → XP_047304892.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X3

  3. XM_047448933.1 → XP_047304889.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X1

  4. XM_047448935.1 → XP_047304891.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    116778012..116809687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347883.1 → XP_054203858.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X2

  2. XM_054347885.1 → XP_054203860.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X3

  3. XM_054347882.1 → XP_054203857.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X1

  4. XM_054347884.1 → XP_054203859.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H974.1 GenPept UniProtKB/Swiss-Prot:Q9H974

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