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NAA16 N-alpha-acetyltransferase 16, NatA auxiliary subunit [ Homo sapiens (human) ]

Gene ID: 79612, updated on 5-Mar-2024

Summary

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Official Symbol
NAA16provided by HGNC
Official Full Name
N-alpha-acetyltransferase 16, NatA auxiliary subunitprovided by HGNC
Primary source
HGNC:HGNC:26164
See related
Ensembl:ENSG00000172766 MIM:619497; AllianceGenome:HGNC:26164
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NARG1L
Summary
Enables ribosome binding activity. Involved in N-terminal protein amino acid acetylation; negative regulation of apoptotic process; and protein stabilization. Located in cytosol. Part of NatA complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 4.0), testis (RPKM 2.5) and 25 other tissues See more
Orthologs
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Genomic context

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See NAA16 in Genome Data Viewer
Location:
13q14.11
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (41311267..41377030)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (40530410..40596042)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (41885403..41951166)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene mitochondrial translation release factor 1 Neighboring gene uncharacterized LOC105370173 Neighboring gene Rac family small GTPase 1 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:41916345-41916845 Neighboring gene RNA, U6 small nuclear 57, pseudogene Neighboring gene tubulin beta pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 5068 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:41995454-41995988 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:41995989-41996521 Neighboring gene olfactory receptor family 7 subfamily E member 36 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase. Arnesen T, et al. BMC Biochem, 2006 Apr 25. PMID 16638120, Free PMC Article
  2. A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1). Arnesen T, et al. BMC Biochem, 2009 May 29. PMID 19480662, Free PMC Article
  3. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. Polevoda B, et al. BMC Proc, 2009 Aug 4. PMID 19660095, Free PMC Article
  4. Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPalpha. Bararia D, et al. Leukemia, 2008 Apr. PMID 18239623
  5. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. Yu Y, et al. Genome Res, 2001 Aug. PMID 11483580, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC40612, DKFZp686O08147

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to ribosome binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in N-terminal peptidyl-methionine acetylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-terminal protein amino acid acetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in N-terminal protein amino acid acetylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NatA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NatA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular exosome HDA PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of transcription regulator complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
N-alpha-acetyltransferase 16, NatA auxiliary subunit
Names
NARG1-like protein
NMDA receptor-regulated 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110798.2 → NP_001104268.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform 3

    See identical proteins and their annotated locations for NP_001104268.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several coding exons and differs in the 3' UTR, compared to variant 1, resulting in a shorter protein (isoform 3) with a unique C-terminus, compared to isoform 1.
    Source sequence(s)
    AL590665, BC064592, BE501152, DB078940
    Consensus CDS
    CCDS45044.1
    UniProtKB/Swiss-Prot
    Q6N069
    Related
    ENSP00000386103.3, ENST00000403412.7
    Conserved Domains (3) summary
    sd00006
    Location:82 → 108
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:87 → 113
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:82 → 145
    TPR_11; TPR repeat

  2. NM_018527.4 → NP_060997.2  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform 2

    See identical proteins and their annotated locations for NP_060997.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal coding exon and several 3' exons but has an alternate 3' segment, compared to variant 1. The resulting isoform (2) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL590665, BC032318, DB078940
    UniProtKB/Swiss-Prot
    Q6N069
    Related
    ENST00000476980.5
    Conserved Domains (3) summary
    sd00006
    Location:82 → 108
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:87 → 113
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:82 → 145
    TPR_11; TPR repeat

  3. NM_024561.5 → NP_078837.3  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform 1

    See identical proteins and their annotated locations for NP_078837.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK097224, AL590665, AL731858, AL833341, DB078940
    Consensus CDS
    CCDS9379.1
    UniProtKB/Swiss-Prot
    B0QZ59, Q5VSP9, Q6N069, Q6P2D5, Q8N5J3, Q8N870
    UniProtKB/TrEMBL
    A4FU51
    Related
    ENSP00000368716.3, ENST00000379406.8
    Conserved Domains (4) summary
    sd00006
    Location:82 → 108
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:87 → 113
    TPR_1; Tetratricopeptide repeat
    pfam12569
    Location:187 → 698
    NARP1; NMDA receptor-regulated protein 1
    pfam13414
    Location:82 → 145
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    41311267..41377030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719866.4 → XP_006719929.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X1

    Conserved Domains (4) summary
    sd00006
    Location:82 → 108
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:87 → 113
    TPR_1; Tetratricopeptide repeat
    pfam12569
    Location:187 → 638
    NARP1; NMDA receptor-regulated protein 1
    pfam13414
    Location:82 → 145
    TPR_11; TPR repeat

  2. XM_011535228.3 → XP_011533530.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X3

    See identical proteins and their annotated locations for XP_011533530.1

    UniProtKB/Swiss-Prot
    Q6N069
    Related
    ENSP00000432364.1, ENST00000464857.5
    Conserved Domains (3) summary
    sd00006
    Location:82 → 108
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:87 → 113
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:82 → 145
    TPR_11; TPR repeat

  3. XM_047430611.1 → XP_047286567.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X4

  4. XM_017020746.3 → XP_016876235.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X7

  5. XM_017020745.3 → XP_016876234.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X5

  6. XM_047430612.1 → XP_047286568.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X6

  7. XM_047430610.1 → XP_047286566.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    40530410..40596042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374961.1 → XP_054230936.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X1

  2. XM_054374963.1 → XP_054230938.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X3

  3. XM_054374964.1 → XP_054230939.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X4

  4. XM_054374967.1 → XP_054230942.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X7

  5. XM_054374966.1 → XP_054230941.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X5

  6. XM_054374965.1 → XP_054230940.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X8

  7. XM_054374962.1 → XP_054230937.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6N069.2 GenPept UniProtKB/Swiss-Prot:Q6N069

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