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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_030464.2 RefSeqGene
- Range
-
89172..137239
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001184779.2 → NP_001171708.1 NADPH oxidase 5 isoform 2
See identical proteins and their annotated locations for NP_001171708.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2, alternately referred to as NOX5 alpha and v1) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
- Source sequence(s)
-
AC027088, AF353088, AI091544, DA868876, DQ413001
- Consensus CDS
-
CCDS53954.1
- UniProtKB/Swiss-Prot
-
Q96PH1
- UniProtKB/TrEMBL
-
A3QRJ0
- Conserved Domains (4) summary
-
- cd06186
Location:420 → 737
- NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
- cd00051
Location:97 → 164
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- pfam01794
Location:268 → 374
- Ferric_reduct; Ferric reductase like transmembrane component
- pfam13499
Location:98 → 162
- EF-hand_7; EF-hand domain pair
-
NM_001184780.2 → NP_001171709.1 NADPH oxidase 5 isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3, alternately referred to as v6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
- Source sequence(s)
-
AC027088, AF325189, AI091544, BC125097, DA739867, DQ413001
- Consensus CDS
-
CCDS53953.1
- UniProtKB/Swiss-Prot
-
Q96PH1
- UniProtKB/TrEMBL
-
A3QRJ0
- Related
- ENSP00000515387.1, ENST00000703585.1
- Conserved Domains (4) summary
-
- cd06186
Location:413 → 730
- NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
- cd00051
Location:90 → 157
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- pfam01794
Location:261 → 367
- Ferric_reduct; Ferric reductase like transmembrane component
- pfam13499
Location:91 → 155
- EF-hand_7; EF-hand domain pair
-
NM_024505.4 → NP_078781.3 NADPH oxidase 5 isoform 1
See identical proteins and their annotated locations for NP_078781.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (1, alternately referred to as NOX5 gamma and v3) encodes the longest isoform (1).
- Source sequence(s)
-
AC027088, AF353089, AI091544, DA868876, DQ413001
- Consensus CDS
-
CCDS32276.2
- UniProtKB/Swiss-Prot
- B2RBJ4, Q08AN2, Q08AN3, Q8TEQ1, Q8TER4, Q96PH1, Q96PH2, Q96PJ8, Q96PJ9, Q9H6E0, Q9HAM8
- Conserved Domains (4) summary
-
- cd06186
Location:448 → 765
- NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
- cd00051
Location:97 → 192
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- pfam01794
Location:296 → 402
- Ferric_reduct; Ferric reductase like transmembrane component
- pfam13499
Location:98 → 190
- EF-hand_7; EF-hand domain pair
RNA
-
NR_033671.3 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (4, also known as NOX5 delta) contains two alternate 5' exons and lacks an exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AC027088, AF325190, AI091544
- Related
-
ENST00000260364.9
-
NR_033672.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (5, also known as NOX5 beta) contains two alternate exons, lacks an alternate exon, and uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AC027088, AF325189, AI091544, DQ413001
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000015.10 Reference GRCh38.p14 Primary Assembly
- Range
-
68930525..69062762
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060939.1 Alternate T2T-CHM13v2.0
- Range
-
66753043..66885315
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)