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DDR1 discoidin domain receptor tyrosine kinase 1 [ Homo sapiens (human) ]

Gene ID: 780, updated on 11-Apr-2024

Summary

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Official Symbol
DDR1provided by HGNC
Official Full Name
discoidin domain receptor tyrosine kinase 1provided by HGNC
Primary source
HGNC:HGNC:2730
See related
Ensembl:ENSG00000204580 MIM:600408; AllianceGenome:HGNC:2730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A
Summary
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in brain (RPKM 49.5), thyroid (RPKM 24.8) and 22 other tissues See more
Orthologs
mouse all
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Genomic context

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See DDR1 in Genome Data Viewer
Location:
6p21.33
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30880970..30900156)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (30745627..30764828)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30848747..30867933)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr6:30808614-30808790 Neighboring gene long intergenic non-protein coding RNA 2570 Neighboring gene Sharpr-MPRA regulatory region 587 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30814964-30815466 Neighboring gene Sharpr-MPRA regulatory region 13207 Neighboring gene RN7SK pseudogene 186 Neighboring gene NANOG hESC enhancer GRCh37_chr6:30845201-30845702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30848468-30849396 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30851831-30852604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30852674-30853181 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30854197-30854703 Neighboring gene microRNA 4640 Neighboring gene general transcription factor IIH subunit 4 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:30889690-30890889 Neighboring gene valyl-tRNA synthetase 2, mitochondrial

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression. Xiong YX, et al. Cell Death Differ, 2023 Jul. PMID 37117273,
  2. DDR1 and Its Ligand, Collagen IV, Are Involved in In Vitro Oligodendrocyte Maturation. Silva ME, et al. Int J Mol Sci, 2023 Jan 16. PMID 36675255, Free PMC Article
  3. DDR1 functions as an immune negative factor in colorectal cancer by regulating tumor-infiltrating T cells through IL-18. Duan X, et al. Cancer Sci, 2022 Nov. PMID 35969377, Free PMC Article
  4. Mechanical Confinement and DDR1 Signaling Synergize to Regulate Collagen-Induced Apoptosis in Rhabdomyosarcoma Cells. Gonzalez-Molina J, et al. Adv Sci (Weinh), 2022 Oct. PMID 35957513, Free PMC Article
  5. Discoidin domain receptor 1 is a potential target correlated with tumor invasion and immune infiltration in gastric cancer. Wang S, et al. Front Immunol, 2022. PMID 35935941, Free PMC Article

See all (222) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder.
    Title: Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder.
  2. Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1) Is a Novel Therapeutic Target in Liposarcoma: A Tissue Microarray Study.
    Title: Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1) Is a Novel Therapeutic Target in Liposarcoma: A Tissue Microarray Study.
  3. DDR1-Induced Paracrine Factors of Hepatocytes Promote HSC Activation and Fibrosis Development.
    Title: DDR1-Induced Paracrine Factors of Hepatocytes Promote HSC Activation and Fibrosis Development.
  4. Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression.
    Title: Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression.
  5. Collagen-induced DDR1 upregulates CXCL5 to promote neutrophil extracellular traps formation and Treg infiltration in breast cancer.
    Title: Collagen-induced DDR1 upregulates CXCL5 to promote neutrophil extracellular traps formation and Treg infiltration in breast cancer.
  6. DDR1 and Its Ligand, Collagen IV, Are Involved in In Vitro Oligodendrocyte Maturation.
    Title: DDR1 and Its Ligand, Collagen IV, Are Involved in In Vitro Oligodendrocyte Maturation.
  7. DDR1 functions as an immune negative factor in colorectal cancer by regulating tumor-infiltrating T cells through IL-18.
    Title: DDR1 functions as an immune negative factor in colorectal cancer by regulating tumor-infiltrating T cells through IL-18.
  8. DDR1 promotes LoVo cell proliferation by regulating energy metabolism.
    Title: DDR1 promotes LoVo cell proliferation by regulating energy metabolism.
  9. Mechanical Confinement and DDR1 Signaling Synergize to Regulate Collagen-Induced Apoptosis in Rhabdomyosarcoma Cells.
    Title: Mechanical Confinement and DDR1 Signaling Synergize to Regulate Collagen-Induced Apoptosis in Rhabdomyosarcoma Cells.
  10. Discoidin domain receptor 1(DDR1) promote intestinal barrier disruption in Ulcerative Colitis through tight junction proteins degradation and epithelium apoptosis.
    Title: Discoidin domain receptor 1(DDR1) promote intestinal barrier disruption in Ulcerative Colitis through tight junction proteins degradation and epithelium apoptosis.
Submit: New GeneRIF Correction See all GeneRIFs (160)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation and the control of HIV-1 in humans.
EBI GWAS Catalog
Genetic predictors of medically refractory ulcerative colitis.
EBI GWAS Catalog
Seven new loci associated with age-related macular degeneration.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables collagen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables collagen binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables collagen binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase collagen receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase collagen receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon development IEA
Inferred from Electronic Annotation
more info
  
involved_in branching involved in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in collagen-activated tyrosine kinase receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in collagen-activated tyrosine kinase receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ear development IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo implantation IEA
Inferred from Electronic Annotation
more info
  
involved_in lactation IEA
Inferred from Electronic Annotation
more info
  
involved_in mammary gland alveolus development IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron projection extension IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-tyrosine autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in smooth muscle cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wound healing, spreading of cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular space HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
epithelial discoidin domain-containing receptor 1
Names
CD167 antigen-like family member A
PTK3A protein tyrosine kinase 3A
cell adhesion kinase
mammary carcinoma kinase 10
neuroepithelial tyrosine kinase
neurotrophic tyrosine kinase, receptor, type 4
protein-tyrosine kinase RTK-6
tyrosine kinase DDR
tyrosine-protein kinase CAK
NP_001189450.1
NP_001189451.1
NP_001189452.2
NP_001284581.1
NP_001284582.1
NP_001284583.1
NP_001374821.1
NP_001374822.1
NP_001374823.1
NP_001374824.1
NP_001374825.1
NP_001374826.1
NP_001374827.1
NP_001374828.1
NP_001374829.1
NP_001374830.1
NP_001374831.1
NP_001374832.1
NP_001374833.1
NP_001374834.1
NP_001374835.1
NP_001374836.1
NP_001374837.1
NP_001374838.1
NP_001374839.1
NP_001374840.1
NP_001374841.1
NP_001374842.1
NP_001374843.1
NP_001374844.1
NP_001374845.1
NP_001374846.1
NP_001374847.1
NP_001397798.1
NP_001945.3
NP_054699.2
NP_054700.2
XP_011513186.1
XP_011513189.1
XP_016866757.1
XP_024302308.1
XP_024302309.1
XP_047275274.1
XP_047275275.1
XP_047275276.1
XP_047275277.1
XP_047275278.1
XP_047275279.1
XP_047275280.1
XP_047275281.1
XP_047275282.1
XP_047275283.1
XP_047275284.1
XP_047275285.1
XP_047275286.1
XP_047275287.1
XP_047275288.1
XP_047275289.1
XP_054185845.1
XP_054185846.1
XP_054185847.1
XP_054185848.1
XP_054185849.1
XP_054185850.1
XP_054185851.1
XP_054185852.1
XP_054185853.1
XP_054185854.1
XP_054185855.1
XP_054185856.1
XP_054186331.1
XP_054186332.1
XP_054186333.1
XP_054186334.1
XP_054186335.1
XP_054186336.1
XP_054186337.1
XP_054186338.1
XP_054186339.1
XP_054186340.1
XP_054186341.1
XP_054186342.1
XP_054186343.1
XP_054186344.1
XP_054186345.1
XP_054186346.1
XP_054186347.1
XP_054186608.1
XP_054186609.1
XP_054186610.1
XP_054186611.1
XP_054186612.1
XP_054186613.1
XP_054186614.1
XP_054186615.1
XP_054186616.1
XP_054186617.1
XP_054186618.1
XP_054186619.1
XP_054186620.1
XP_054186621.1
XP_054186622.1
XP_054186623.1
XP_054186624.1
XP_054186625.1
XP_054186626.1
XP_054187105.1
XP_054187106.1
XP_054187107.1
XP_054187108.1
XP_054187109.1
XP_054187110.1
XP_054187111.1
XP_054187112.1
XP_054187113.1
XP_054187114.1
XP_054187115.1
XP_054187116.1
XP_054187117.1
XP_054187118.1
XP_054187119.1
XP_054187120.1
XP_054187121.1
XP_054187122.1
XP_054187123.1
XP_054212333.1
XP_054212334.1
XP_054212335.1
XP_054212336.1
XP_054212337.1
XP_054212338.1
XP_054212339.1
XP_054212340.1
XP_054212341.1
XP_054212342.1
XP_054212343.1
XP_054212344.1
XP_054212345.1
XP_054212346.1
XP_054212347.1
XP_054212348.1
XP_054212349.1
XP_054212350.1
XP_054212351.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029066.1 RefSeqGene

    Range
    5436..21073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202521.1 → NP_001189450.1  epithelial discoidin domain-containing receptor 1 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AF353182, BC008716, L20817
    UniProtKB/Swiss-Prot
    Q08345
    UniProtKB/TrEMBL
    Q96T62
    Conserved Domains (2) summary
    smart00231
    Location:30 → 185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  2. NM_001202522.1 → NP_001189451.1  epithelial discoidin domain-containing receptor 1 isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AF353183, BC008716, L20817
    Consensus CDS
    CCDS75419.1
    UniProtKB/TrEMBL
    A0A0A0MSX3, A0A0G2JNZ7
    Related
    ENSP00000405998.2, ENST00000446312.5
    Conserved Domains (2) summary
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:478 → 761
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001202523.3 → NP_001189452.2  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS4690.1
    UniProtKB/TrEMBL
    A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:567 → 870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  4. NM_001297652.2 → NP_001284581.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001284581.1

    Status: REVIEWED

    Source sequence(s)
    AK291621, AK294793, BC008716, DA461082
    Consensus CDS
    CCDS4690.1
    UniProtKB/TrEMBL
    A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Related
    ENSP00000407699.2, ENST00000418800.6
    Conserved Domains (2) summary
    cd05096
    Location:567 → 870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  5. NM_001297653.2 → NP_001284582.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001284582.1

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS4690.1
    UniProtKB/TrEMBL
    A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:567 → 870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  6. NM_001297654.2 → NP_001284583.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001284583.1

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS34385.1
    UniProtKB/Swiss-Prot
    B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Related
    ENSP00000365752.3, ENST00000376568.8
    Conserved Domains (2) summary
    cd05096
    Location:604 → 907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  7. NM_001387892.1 → NP_001374821.1  epithelial discoidin domain-containing receptor 1 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS47396.1
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Related
    ENSP00000427552.1, ENST00000513240.5
    Conserved Domains (2) summary
    cd05096
    Location:604 → 913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  8. NM_001387893.1 → NP_001374822.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS34385.1
    UniProtKB/Swiss-Prot
    B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:604 → 907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  9. NM_001387894.1 → NP_001374823.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS34385.1
    UniProtKB/Swiss-Prot
    B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:604 → 907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  10. NM_001387895.1 → NP_001374824.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS34385.1
    UniProtKB/Swiss-Prot
    B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:604 → 907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  11. NM_001387896.1 → NP_001374825.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS34385.1
    UniProtKB/Swiss-Prot
    B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:604 → 907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  12. NM_001387897.1 → NP_001374826.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS34385.1
    UniProtKB/Swiss-Prot
    B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:604 → 907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  13. NM_001387898.1 → NP_001374827.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS34385.1
    UniProtKB/Swiss-Prot
    B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:604 → 907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  14. NM_001387899.1 → NP_001374828.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS34385.1
    UniProtKB/Swiss-Prot
    B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:604 → 907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  15. NM_001387900.1 → NP_001374829.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS34385.1
    UniProtKB/Swiss-Prot
    B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:604 → 907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  16. NM_001387901.1 → NP_001374830.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS34385.1
    UniProtKB/Swiss-Prot
    B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:604 → 907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  17. NM_001387902.1 → NP_001374831.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS34385.1
    UniProtKB/Swiss-Prot
    B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:604 → 907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  18. NM_001387903.1 → NP_001374832.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS34385.1
    UniProtKB/Swiss-Prot
    B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:604 → 907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  19. NM_001387904.1 → NP_001374833.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS34385.1
    UniProtKB/Swiss-Prot
    B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:604 → 907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  20. NM_001387905.1 → NP_001374834.1  epithelial discoidin domain-containing receptor 1 isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:567 → 876
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  21. NM_001387906.1 → NP_001374835.1  epithelial discoidin domain-containing receptor 1 isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:567 → 876
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  22. NM_001387907.1 → NP_001374836.1  epithelial discoidin domain-containing receptor 1 isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:567 → 876
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  23. NM_001387908.1 → NP_001374837.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS4690.1
    UniProtKB/TrEMBL
    A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:567 → 870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  24. NM_001387909.1 → NP_001374838.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS4690.1
    UniProtKB/TrEMBL
    A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:567 → 870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  25. NM_001387910.1 → NP_001374839.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS4690.1
    UniProtKB/TrEMBL
    A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:567 → 870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  26. NM_001387911.1 → NP_001374840.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS4690.1
    UniProtKB/TrEMBL
    A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:567 → 870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  27. NM_001387912.1 → NP_001374841.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS4690.1
    UniProtKB/TrEMBL
    A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:567 → 870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  28. NM_001387913.1 → NP_001374842.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS4690.1
    UniProtKB/TrEMBL
    A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:567 → 870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  29. NM_001387914.1 → NP_001374843.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS4690.1
    UniProtKB/TrEMBL
    A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Related
    ENSP00000365753.3, ENST00000376569.7
    Conserved Domains (2) summary
    cd05096
    Location:567 → 870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  30. NM_001387915.1 → NP_001374844.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS4690.1
    UniProtKB/TrEMBL
    A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:567 → 870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  31. NM_001387916.1 → NP_001374845.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS4690.1
    UniProtKB/TrEMBL
    A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:567 → 870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  32. NM_001387917.1 → NP_001374846.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS4690.1
    UniProtKB/TrEMBL
    A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:567 → 870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  33. NM_001387918.1 → NP_001374847.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS4690.1
    UniProtKB/TrEMBL
    A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:567 → 870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  34. NM_001410869.1 → NP_001397798.1  epithelial discoidin domain-containing receptor 1 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS93879.1
    Related
    ENSP00000422442.1, ENST00000508312.5

  35. NM_001954.5 → NP_001945.3  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001945.3

    Status: REVIEWED

    Source sequence(s)
    BC008716, BC070070
    Consensus CDS
    CCDS4690.1
    UniProtKB/TrEMBL
    A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Related
    ENSP00000365754.4, ENST00000376570.8
    Conserved Domains (2) summary
    cd05096
    Location:567 → 870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  36. NM_013993.3 → NP_054699.2  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_054699.2

    Status: REVIEWED

    Source sequence(s)
    AL662870, BC008716, CN362335, L11315
    Consensus CDS
    CCDS34385.1
    UniProtKB/Swiss-Prot
    B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Related
    ENSP00000405039.1, ENST00000452441.5
    Conserved Domains (2) summary
    cd05096
    Location:604 → 907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  37. NM_013994.3 → NP_054700.2  epithelial discoidin domain-containing receptor 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_054700.2

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS47396.1
    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:604 → 913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    30880970..30900156
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419324.1 → XP_047275280.1  epithelial discoidin domain-containing receptor 1 isoform X1

  2. XM_011514884.2 → XP_011513186.1  epithelial discoidin domain-containing receptor 1 isoform X5

    See identical proteins and their annotated locations for XP_011513186.1

    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:604 → 913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  3. XM_011514887.3 → XP_011513189.1  epithelial discoidin domain-containing receptor 1 isoform X5

    See identical proteins and their annotated locations for XP_011513189.1

    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:604 → 913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  4. XM_047419329.1 → XP_047275285.1  epithelial discoidin domain-containing receptor 1 isoform X5

  5. XM_047419318.1 → XP_047275274.1  epithelial discoidin domain-containing receptor 1 isoform X1

  6. XM_024446541.2 → XP_024302309.1  epithelial discoidin domain-containing receptor 1 isoform X5

    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:604 → 913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  7. XM_047419321.1 → XP_047275277.1  epithelial discoidin domain-containing receptor 1 isoform X1

  8. XM_047419322.1 → XP_047275278.1  epithelial discoidin domain-containing receptor 1 isoform X1

  9. XM_047419320.1 → XP_047275276.1  epithelial discoidin domain-containing receptor 1 isoform X1

  10. XM_047419319.1 → XP_047275275.1  epithelial discoidin domain-containing receptor 1 isoform X1

  11. XM_047419326.1 → XP_047275282.1  epithelial discoidin domain-containing receptor 1 isoform X2

  12. XM_047419333.1 → XP_047275289.1  epithelial discoidin domain-containing receptor 1 isoform X3

  13. XM_017011268.3 → XP_016866757.1  epithelial discoidin domain-containing receptor 1 isoform X5

    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:604 → 913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  14. XM_047419323.1 → XP_047275279.1  epithelial discoidin domain-containing receptor 1 isoform X1

  15. XM_047419330.1 → XP_047275286.1  epithelial discoidin domain-containing receptor 1 isoform X5

  16. XM_047419328.1 → XP_047275284.1  epithelial discoidin domain-containing receptor 1 isoform X5

  17. XM_047419325.1 → XP_047275281.1  epithelial discoidin domain-containing receptor 1 isoform X2

  18. XM_047419331.1 → XP_047275287.1  epithelial discoidin domain-containing receptor 1 isoform X4

  19. XM_047419332.1 → XP_047275288.1  epithelial discoidin domain-containing receptor 1 isoform X3

  20. XM_024446540.2 → XP_024302308.1  epithelial discoidin domain-containing receptor 1 isoform X5

    UniProtKB/TrEMBL
    A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
    Conserved Domains (2) summary
    cd05096
    Location:604 → 913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  21. XM_047419327.1 → XP_047275283.1  epithelial discoidin domain-containing receptor 1 isoform X5

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    2214565..2218962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    2360739..2379927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329873.1 → XP_054185848.1  epithelial discoidin domain-containing receptor 1 isoform X1

  2. XM_054329879.1 → XP_054185854.1  epithelial discoidin domain-containing receptor 1 isoform X5

  3. XM_054329875.1 → XP_054185850.1  epithelial discoidin domain-containing receptor 1 isoform X5

  4. XM_054329881.1 → XP_054185856.1  epithelial discoidin domain-containing receptor 1 isoform X5

  5. XM_054329870.1 → XP_054185845.1  epithelial discoidin domain-containing receptor 1 isoform X1

  6. XM_054329880.1 → XP_054185855.1  epithelial discoidin domain-containing receptor 1 isoform X5

  7. XM_054329872.1 → XP_054185847.1  epithelial discoidin domain-containing receptor 1 isoform X1

  8. XM_054329871.1 → XP_054185846.1  epithelial discoidin domain-containing receptor 1 isoform X1

  9. XM_054329876.1 → XP_054185851.1  epithelial discoidin domain-containing receptor 1 isoform X5

  10. XM_054329874.1 → XP_054185849.1  epithelial discoidin domain-containing receptor 1 isoform X2

  11. XM_054329877.1 → XP_054185852.1  epithelial discoidin domain-containing receptor 1 isoform X5

  12. XM_054329878.1 → XP_054185853.1  epithelial discoidin domain-containing receptor 1 isoform X5

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    2137265..2156466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330358.1 → XP_054186333.1  epithelial discoidin domain-containing receptor 1 isoform X6

  2. XM_054330363.1 → XP_054186338.1  epithelial discoidin domain-containing receptor 1 isoform X8

  3. XM_054330365.1 → XP_054186340.1  epithelial discoidin domain-containing receptor 1 isoform X8

  4. XM_054330356.1 → XP_054186331.1  epithelial discoidin domain-containing receptor 1 isoform X6

  5. XM_054330366.1 → XP_054186341.1  epithelial discoidin domain-containing receptor 1 isoform X8

  6. XM_054330357.1 → XP_054186332.1  epithelial discoidin domain-containing receptor 1 isoform X6

  7. XM_054330360.1 → XP_054186335.1  epithelial discoidin domain-containing receptor 1 isoform X8

  8. XM_054330369.1 → XP_054186344.1  epithelial discoidin domain-containing receptor 1 isoform X9

  9. XM_054330372.1 → XP_054186347.1  epithelial discoidin domain-containing receptor 1 isoform X12

  10. XM_054330367.1 → XP_054186342.1  epithelial discoidin domain-containing receptor 1 isoform X8

  11. XM_054330368.1 → XP_054186343.1  epithelial discoidin domain-containing receptor 1 isoform X8

  12. XM_054330364.1 → XP_054186339.1  epithelial discoidin domain-containing receptor 1 isoform X8

  13. XM_054330359.1 → XP_054186334.1  epithelial discoidin domain-containing receptor 1 isoform X7

  14. XM_054330370.1 → XP_054186345.1  epithelial discoidin domain-containing receptor 1 isoform X10

  15. XM_054330371.1 → XP_054186346.1  epithelial discoidin domain-containing receptor 1 isoform X11

  16. XM_054330361.1 → XP_054186336.1  epithelial discoidin domain-containing receptor 1 isoform X8

  17. XM_054330362.1 → XP_054186337.1  epithelial discoidin domain-containing receptor 1 isoform X8

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    2191212..2210394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330638.1 → XP_054186613.1  epithelial discoidin domain-containing receptor 1 isoform X1

  2. XM_054330645.1 → XP_054186620.1  epithelial discoidin domain-containing receptor 1 isoform X5

  3. XM_054330641.1 → XP_054186616.1  epithelial discoidin domain-containing receptor 1 isoform X5

  4. XM_054330648.1 → XP_054186623.1  epithelial discoidin domain-containing receptor 1 isoform X5

  5. XM_054330633.1 → XP_054186608.1  epithelial discoidin domain-containing receptor 1 isoform X1

  6. XM_054330647.1 → XP_054186622.1  epithelial discoidin domain-containing receptor 1 isoform X5

  7. XM_054330636.1 → XP_054186611.1  epithelial discoidin domain-containing receptor 1 isoform X1

  8. XM_054330637.1 → XP_054186612.1  epithelial discoidin domain-containing receptor 1 isoform X1

  9. XM_054330635.1 → XP_054186610.1  epithelial discoidin domain-containing receptor 1 isoform X1

  10. XM_054330634.1 → XP_054186609.1  epithelial discoidin domain-containing receptor 1 isoform X1

  11. XM_054330640.1 → XP_054186615.1  epithelial discoidin domain-containing receptor 1 isoform X2

  12. XM_054330651.1 → XP_054186626.1  epithelial discoidin domain-containing receptor 1 isoform X3

  13. XM_054330642.1 → XP_054186617.1  epithelial discoidin domain-containing receptor 1 isoform X5

  14. XM_054330646.1 → XP_054186621.1  epithelial discoidin domain-containing receptor 1 isoform X5

  15. XM_054330639.1 → XP_054186614.1  epithelial discoidin domain-containing receptor 1 isoform X2

  16. XM_054330649.1 → XP_054186624.1  epithelial discoidin domain-containing receptor 1 isoform X4

  17. XM_054330650.1 → XP_054186625.1  epithelial discoidin domain-containing receptor 1 isoform X3

  18. XM_054330643.1 → XP_054186618.1  epithelial discoidin domain-containing receptor 1 isoform X5

  19. XM_054330644.1 → XP_054186619.1  epithelial discoidin domain-containing receptor 1 isoform X5

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    2225119..2249066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    2136138..2155326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331135.1 → XP_054187110.1  epithelial discoidin domain-containing receptor 1 isoform X1

  2. XM_054331142.1 → XP_054187117.1  epithelial discoidin domain-containing receptor 1 isoform X5

  3. XM_054331138.1 → XP_054187113.1  epithelial discoidin domain-containing receptor 1 isoform X5

  4. XM_054331145.1 → XP_054187120.1  epithelial discoidin domain-containing receptor 1 isoform X5

  5. XM_054331130.1 → XP_054187105.1  epithelial discoidin domain-containing receptor 1 isoform X1

  6. XM_054331144.1 → XP_054187119.1  epithelial discoidin domain-containing receptor 1 isoform X5

  7. XM_054331133.1 → XP_054187108.1  epithelial discoidin domain-containing receptor 1 isoform X1

  8. XM_054331134.1 → XP_054187109.1  epithelial discoidin domain-containing receptor 1 isoform X1

  9. XM_054331132.1 → XP_054187107.1  epithelial discoidin domain-containing receptor 1 isoform X1

  10. XM_054331131.1 → XP_054187106.1  epithelial discoidin domain-containing receptor 1 isoform X1

  11. XM_054331137.1 → XP_054187112.1  epithelial discoidin domain-containing receptor 1 isoform X2

  12. XM_054331148.1 → XP_054187123.1  epithelial discoidin domain-containing receptor 1 isoform X3

  13. XM_054331139.1 → XP_054187114.1  epithelial discoidin domain-containing receptor 1 isoform X5

  14. XM_054331143.1 → XP_054187118.1  epithelial discoidin domain-containing receptor 1 isoform X5

  15. XM_054331136.1 → XP_054187111.1  epithelial discoidin domain-containing receptor 1 isoform X2

  16. XM_054331146.1 → XP_054187121.1  epithelial discoidin domain-containing receptor 1 isoform X4

  17. XM_054331147.1 → XP_054187122.1  epithelial discoidin domain-containing receptor 1 isoform X3

  18. XM_054331140.1 → XP_054187115.1  epithelial discoidin domain-containing receptor 1 isoform X5

  19. XM_054331141.1 → XP_054187116.1  epithelial discoidin domain-containing receptor 1 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    30745627..30764828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356365.1 → XP_054212340.1  epithelial discoidin domain-containing receptor 1 isoform X1

  2. XM_054356371.1 → XP_054212346.1  epithelial discoidin domain-containing receptor 1 isoform X5

  3. XM_054356375.1 → XP_054212350.1  epithelial discoidin domain-containing receptor 1 isoform X5

  4. XM_054356374.1 → XP_054212349.1  epithelial discoidin domain-containing receptor 1 isoform X5

  5. XM_054356366.1 → XP_054212341.1  epithelial discoidin domain-containing receptor 1 isoform X2

  6. XM_054356369.1 → XP_054212344.1  epithelial discoidin domain-containing receptor 1 isoform X5

  7. XM_054356370.1 → XP_054212345.1  epithelial discoidin domain-containing receptor 1 isoform X5

  8. XM_054356358.1 → XP_054212333.1  epithelial discoidin domain-containing receptor 1 isoform X1

  9. XM_054356373.1 → XP_054212348.1  epithelial discoidin domain-containing receptor 1 isoform X5

  10. XM_054356359.1 → XP_054212334.1  epithelial discoidin domain-containing receptor 1 isoform X1

  11. XM_054356362.1 → XP_054212337.1  epithelial discoidin domain-containing receptor 1 isoform X1

  12. XM_054356364.1 → XP_054212339.1  epithelial discoidin domain-containing receptor 1 isoform X1

  13. XM_054356363.1 → XP_054212338.1  epithelial discoidin domain-containing receptor 1 isoform X1

  14. XM_054356361.1 → XP_054212336.1  epithelial discoidin domain-containing receptor 1 isoform X1

  15. XM_054356367.1 → XP_054212342.1  epithelial discoidin domain-containing receptor 1 isoform X2

  16. XM_054356376.1 → XP_054212351.1  epithelial discoidin domain-containing receptor 1 isoform X3

  17. XM_054356372.1 → XP_054212347.1  epithelial discoidin domain-containing receptor 1 isoform X5

  18. XM_054356368.1 → XP_054212343.1  epithelial discoidin domain-containing receptor 1 isoform X5

  19. XM_054356360.1 → XP_054212335.1  epithelial discoidin domain-containing receptor 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08345.1 GenPept UniProtKB/Swiss-Prot:Q08345

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