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ZNF217 zinc finger protein 217 [ Homo sapiens (human) ]

Gene ID: 7764, updated on 3-Apr-2024

Summary

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Official Symbol
ZNF217provided by HGNC
Official Full Name
zinc finger protein 217provided by HGNC
Primary source
HGNC:HGNC:13009
See related
Ensembl:ENSG00000171940 MIM:602967; AllianceGenome:HGNC:13009
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZABC1
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in mitochondrion and nuclear speck. Part of histone deacetylase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in urinary bladder (RPKM 14.5), spleen (RPKM 14.3) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF217 in Genome Data Viewer
Location:
20q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (53567071..53597702, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (55339255..55382109, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (52183610..52210378, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene teashirt zinc finger homeobox 2 Neighboring gene uncharacterized LOC105372669 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:52077141-52077719 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:52077720-52078297 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:52089451-52090068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:52120609-52121259 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:52126933-52127434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:52127435-52127934 Neighboring gene uncharacterized LOC105372671 Neighboring gene reporter assay-validated silencer 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:52173455-52173955 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:52175886-52176069 Neighboring gene ZNF217 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:52189693-52189843 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:52198379-52199170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:52214839-52215339 Neighboring gene uncharacterized LOC105372672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18123 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:52238084-52238848 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:52243436-52243628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18125 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18130 Neighboring gene RNA, U7 small nuclear 14 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K-AKT Signaling for the Treatment of Metastatic Osteosarcoma. Smeester BA, et al. Mol Cancer Ther, 2020 Dec. PMID 32999043, Free PMC Article
  2. Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217. Northey JJ, et al. J Clin Invest, 2020 Nov 2. PMID 32721948, Free PMC Article
  3. Zinc finger gene 217 (ZNF217) Promoted Ovarian Hyperstimulation Syndrome (OHSS) through Regulating E(2) Synthesis and Inhibiting Thrombospondin-1 (TSP-1). Zhai J, et al. Sci Rep, 2017 Jun 12. PMID 28607476, Free PMC Article
  4. The critical role of the ZNF217 oncogene in promoting breast cancer metastasis to the bone. Bellanger A, et al. J Pathol, 2017 May. PMID 28207159
  5. Elevated expression of ZNF217 promotes prostate cancer growth by restraining ferroportin-conducted iron egress. Jiang X, et al. Oncotarget, 2016 Dec 20. PMID 27768596, Free PMC Article

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma.
    Title: Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma.
  2. FTO-stabilized miR-139-5p targets ZNF217 to suppress prostate cancer cell malignancies by inactivating the PI3K/Akt/mTOR signal pathway.
    Title: FTO-stabilized miR-139-5p targets ZNF217 to suppress prostate cancer cell malignancies by inactivating the PI3K/Akt/mTOR signal pathway.
  3. Hsa_circ_0069094 positively regulates the expression of oncogenic ZNF217 by competitively targeting miR-758-3p to promote the development of breast cancer.
    Title: Hsa_circ_0069094 positively regulates the expression of oncogenic ZNF217 by competitively targeting miR-758-3p to promote the development of breast cancer.
  4. MicroRNA-135 inhibits initiation of epithelial-mesenchymal transition in breast cancer by targeting ZNF217 and promoting m6A modification of NANOG.
    Title: MicroRNA-135 inhibits initiation of epithelial-mesenchymal transition in breast cancer by targeting ZNF217 and promoting m6A modification of NANOG.
  5. Interferon regulatory factor 5induced upregulation of zincfinger protein 217 promotes pancreatic carcinoma progression.
    Title: Interferon regulatory factor 5‑induced upregulation of zinc‑finger protein 217 promotes pancreatic carcinoma progression.
  6. lncRNA SNHG1 Knockdown Alleviates Amyloid-beta-Induced Neuronal Injury by Regulating ZNF217 via Sponging miR-361-3p in Alzheimer's Disease.
    Title: lncRNA SNHG1 Knockdown Alleviates Amyloid-β-Induced Neuronal Injury by Regulating ZNF217 via Sponging miR-361-3p in Alzheimer's Disease.
  7. Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K-AKT Signaling for the Treatment of Metastatic Osteosarcoma.
    Title: Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K-AKT Signaling for the Treatment of Metastatic Osteosarcoma.
  8. Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.
    Title: Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.
  9. Indicated ZNF217 could recruit LSD1 to affect CDH1 epigenetic expression from transcription level.
    Title: The coordination between ZNF217 and LSD1 contributes to hepatocellular carcinoma progress and is negatively regulated by miR-101.
  10. ZNF217 inhibited both COX2 and PGE2 synthesis through estradiol in KGN cells. ZNF217 and aromatase were decreased, whereas COX2 and PGE2 were increased in the GC of women with PCOS
    Title: A candidate pathogenic gene, zinc finger gene 217 (ZNF217), may contribute to polycystic ovary syndrome through prostaglandin E2.
Submit: New GeneRIF Correction See all GeneRIFs (46)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of histone deacetylase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 217

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385034.1 → NP_001371963.1  zinc finger protein 217 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL157838
    UniProtKB/TrEMBL
    A8K2T5
    Conserved Domains (7) summary
    PHA03247
    Location:750 → 970
    PHA03247; large tegument protein UL36; Provisional
    COG5048
    Location:468 → 733
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:130 → 150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:473 → 493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:472 → 493
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:485 → 510
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:499 → 523
    zf-H2C2_5; C2H2-type zinc-finger domain

  2. NM_006526.3 → NP_006517.1  zinc finger protein 217 isoform 2

    See identical proteins and their annotated locations for NP_006517.1

    Status: REVIEWED

    Source sequence(s)
    AL157838
    Consensus CDS
    CCDS13443.1
    UniProtKB/Swiss-Prot
    E1P5Y6, O75362, Q14DB8
    UniProtKB/TrEMBL
    A8K2T5
    Related
    ENSP00000360526.2, ENST00000371471.7
    Conserved Domains (5) summary
    sd00017
    Location:130 → 150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:473 → 493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:472 → 493
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:485 → 510
    zf-H2C2_2; Zinc-finger double domain
    cl26464
    Location:750 → 938
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    53567071..53597702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529036.2 → XP_011527338.1  zinc finger protein 217 isoform X1

    See identical proteins and their annotated locations for XP_011527338.1

    UniProtKB/TrEMBL
    A8K2T5
    Conserved Domains (7) summary
    PHA03247
    Location:750 → 970
    PHA03247; large tegument protein UL36; Provisional
    COG5048
    Location:468 → 733
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:130 → 150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:473 → 493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:472 → 493
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:485 → 510
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:499 → 523
    zf-H2C2_5; C2H2-type zinc-finger domain

  2. XM_047440462.1 → XP_047296418.1  zinc finger protein 217 isoform X1

  3. XM_005260545.5 → XP_005260602.1  zinc finger protein 217 isoform X1

    See identical proteins and their annotated locations for XP_005260602.1

    UniProtKB/TrEMBL
    A8K2T5
    Conserved Domains (7) summary
    PHA03247
    Location:750 → 970
    PHA03247; large tegument protein UL36; Provisional
    COG5048
    Location:468 → 733
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:130 → 150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:473 → 493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:472 → 493
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:485 → 510
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:499 → 523
    zf-H2C2_5; C2H2-type zinc-finger domain

  4. XM_047440459.1 → XP_047296415.1  zinc finger protein 217 isoform X1

  5. XM_024451997.2 → XP_024307765.1  zinc finger protein 217 isoform X1

    UniProtKB/TrEMBL
    A8K2T5
    Conserved Domains (7) summary
    PHA03247
    Location:750 → 970
    PHA03247; large tegument protein UL36; Provisional
    COG5048
    Location:468 → 733
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:130 → 150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:473 → 493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:472 → 493
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:485 → 510
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:499 → 523
    zf-H2C2_5; C2H2-type zinc-finger domain

  6. XM_047440461.1 → XP_047296417.1  zinc finger protein 217 isoform X1

  7. XM_024451998.2 → XP_024307766.1  zinc finger protein 217 isoform X1

    UniProtKB/TrEMBL
    A8K2T5
    Conserved Domains (7) summary
    PHA03247
    Location:750 → 970
    PHA03247; large tegument protein UL36; Provisional
    COG5048
    Location:468 → 733
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:130 → 150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:473 → 493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:472 → 493
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:485 → 510
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:499 → 523
    zf-H2C2_5; C2H2-type zinc-finger domain

  8. XM_047440460.1 → XP_047296416.1  zinc finger protein 217 isoform X1

  9. XM_047440464.1 → XP_047296420.1  zinc finger protein 217 isoform X2

    UniProtKB/Swiss-Prot
    E1P5Y6, O75362, Q14DB8

  10. XM_047440463.1 → XP_047296419.1  zinc finger protein 217 isoform X2

    UniProtKB/Swiss-Prot
    E1P5Y6, O75362, Q14DB8

  11. XM_047440465.1 → XP_047296421.1  zinc finger protein 217 isoform X2

    UniProtKB/Swiss-Prot
    E1P5Y6, O75362, Q14DB8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    55339255..55382109 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323963.1 → XP_054179938.1  zinc finger protein 217 isoform X1

  2. XM_054323969.1 → XP_054179944.1  zinc finger protein 217 isoform X1

  3. XM_054323965.1 → XP_054179940.1  zinc finger protein 217 isoform X1

  4. XM_054323964.1 → XP_054179939.1  zinc finger protein 217 isoform X1

  5. XM_054323967.1 → XP_054179942.1  zinc finger protein 217 isoform X1

  6. XM_054323968.1 → XP_054179943.1  zinc finger protein 217 isoform X1

  7. XM_054323966.1 → XP_054179941.1  zinc finger protein 217 isoform X1

  8. XM_054323971.1 → XP_054179946.1  zinc finger protein 217 isoform X2

  9. XM_054323970.1 → XP_054179945.1  zinc finger protein 217 isoform X2

  10. XM_054323972.1 → XP_054179947.1  zinc finger protein 217 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75362.1 GenPept UniProtKB/Swiss-Prot:O75362

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