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ZNF202 zinc finger protein 202 [ Homo sapiens (human) ]

Gene ID: 7753, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF202provided by HGNC
Official Full Name
zinc finger protein 202provided by HGNC
Primary source
HGNC:HGNC:12994
See related
Ensembl:ENSG00000166261 MIM:603430; AllianceGenome:HGNC:12994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZSCAN42; ZKSCAN10
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in chromosome; nuclear body; and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 4.3), ovary (RPKM 3.3) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF202 in Genome Data Viewer
Location:
11q24.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (123723914..123741660, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (123752703..123770446, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (123594622..123612368, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902777 Neighboring gene sodium voltage-gated channel beta subunit 3 Neighboring gene uncharacterized LOC105369543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:123572538-123573038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:123573039-123573539 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:123599312-123600511 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4023 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:123612953-123613550 Neighboring gene olfactory receptor family 6 subfamily X member 1 Neighboring gene RNA, U1 small nuclear 21, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Functional promoter variant in zinc finger protein 202 predicts severe atherosclerosis and ischemic heart disease. Stene MC, et al. J Am Coll Cardiol, 2008 Jul 29. PMID 18652945
  2. Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population. Stene MC, et al. J Lipid Res, 2006 May. PMID 16467280
  3. Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study. Stene MC, et al. Atherosclerosis, 2006 Sep. PMID 16289551
  4. Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins. Monaco C, et al. Genomics, 1998 Sep 15. PMID 9790754
  5. SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain. Babb R, et al. Biochem J, 2003 Mar 1. PMID 12444922, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  2. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genomewide association study of movement-related adverse antipsychotic effects.
  3. SOX17-Chromatin immunoprecipitation identified zinc finger protein 202 (Zfp202) as a direct target of SOX17 during endoderm differentiation of F9 embryonal carcinoma cells.
    Title: SOX17 directly activates Zfp202 transcription during in vitro endoderm differentiation.
  4. Homozygosity for a common functional promoter variant in ZNF202 predicts severe atherosclerosis and an increased risk of IHD.
    Title: Functional promoter variant in zinc finger protein 202 predicts severe atherosclerosis and ischemic heart disease.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  6. findings show that genetic variation in ZNF202 is common in the general population. However, SNPs in the protein-coding region of ZNF202 do not make a major contribution to HDL cholesterol levels.
    Title: Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population.
  7. This is the first study to suggest that ZNF202 could be a new candidate gene for ischemic heart disease and myocardial infarction in the general population.
    Title: Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genomewide association study of movement-related adverse antipsychotic effects.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human zinc finger protein 202 (ZNF202) at amino acid residues 68-69 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
zinc finger protein 202
Names
zinc finger protein with KRAB and SCAN domains 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301779.2 → NP_001288708.1  zinc finger protein 202 isoform 1

    See identical proteins and their annotated locations for NP_001288708.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AK226047, AL162031, AP000868, BC013382, DA770117, H89560, H89561
    Consensus CDS
    CCDS8443.1
    UniProtKB/Swiss-Prot
    B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
    Related
    ENSP00000337724.4, ENST00000336139.8
    Conserved Domains (8) summary
    smart00431
    Location:43 → 153
    SCAN; leucine rich region
    smart00349
    Location:237 → 297
    KRAB; krueppel associated box
    COG5048
    Location:397 → 644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567 → 587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593 → 615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237 → 277
    KRAB; KRAB box
    pfam02023
    Location:43 → 130
    SCAN; SCAN domain
    pfam13465
    Location:607 → 632
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001301780.2 → NP_001288709.1  zinc finger protein 202 isoform 1

    See identical proteins and their annotated locations for NP_001288709.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AK023751, AL162031, AP000868, BC013382, DA770117, H89560, H89561, HY056142
    Consensus CDS
    CCDS8443.1
    UniProtKB/Swiss-Prot
    B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
    Related
    ENSP00000433881.1, ENST00000529691.1
    Conserved Domains (8) summary
    smart00431
    Location:43 → 153
    SCAN; leucine rich region
    smart00349
    Location:237 → 297
    KRAB; krueppel associated box
    COG5048
    Location:397 → 644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567 → 587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593 → 615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237 → 277
    KRAB; KRAB box
    pfam02023
    Location:43 → 130
    SCAN; SCAN domain
    pfam13465
    Location:607 → 632
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001301819.1 → NP_001288748.1  zinc finger protein 202 isoform 2

    See identical proteins and their annotated locations for NP_001288748.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF027218, AL162031, BC013382, DA770117, H89560, H89561
    UniProtKB/Swiss-Prot
    O95125
    Conserved Domains (3) summary
    smart00349
    Location:13 → 73
    KRAB; krueppel associated box
    COG5048
    Location:367 → 424
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:343 → 363
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_003455.4 → NP_003446.2  zinc finger protein 202 isoform 1

    See identical proteins and their annotated locations for NP_003446.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AL162031, AP000868, BC013382, DA770117, H89560, H89561, HY056142
    Consensus CDS
    CCDS8443.1
    UniProtKB/Swiss-Prot
    B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
    Related
    ENSP00000432504.1, ENST00000530393.6
    Conserved Domains (8) summary
    smart00431
    Location:43 → 153
    SCAN; leucine rich region
    smart00349
    Location:237 → 297
    KRAB; krueppel associated box
    COG5048
    Location:397 → 644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567 → 587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593 → 615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237 → 277
    KRAB; KRAB box
    pfam02023
    Location:43 → 130
    SCAN; SCAN domain
    pfam13465
    Location:607 → 632
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    123723914..123741660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271661.2 → XP_005271718.1  zinc finger protein 202 isoform X1

    See identical proteins and their annotated locations for XP_005271718.1

    UniProtKB/Swiss-Prot
    B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
    Conserved Domains (8) summary
    smart00431
    Location:43 → 153
    SCAN; leucine rich region
    smart00349
    Location:237 → 297
    KRAB; krueppel associated box
    COG5048
    Location:397 → 644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567 → 587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593 → 615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237 → 277
    KRAB; KRAB box
    pfam02023
    Location:43 → 130
    SCAN; SCAN domain
    pfam13465
    Location:607 → 632
    zf-H2C2_2; Zinc-finger double domain

  2. XM_005271659.2 → XP_005271716.1  zinc finger protein 202 isoform X1

    See identical proteins and their annotated locations for XP_005271716.1

    UniProtKB/Swiss-Prot
    B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
    Conserved Domains (8) summary
    smart00431
    Location:43 → 153
    SCAN; leucine rich region
    smart00349
    Location:237 → 297
    KRAB; krueppel associated box
    COG5048
    Location:397 → 644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567 → 587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593 → 615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237 → 277
    KRAB; KRAB box
    pfam02023
    Location:43 → 130
    SCAN; SCAN domain
    pfam13465
    Location:607 → 632
    zf-H2C2_2; Zinc-finger double domain

  3. XM_017018268.3 → XP_016873757.1  zinc finger protein 202 isoform X1

    UniProtKB/Swiss-Prot
    B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
    Conserved Domains (8) summary
    smart00431
    Location:43 → 153
    SCAN; leucine rich region
    smart00349
    Location:237 → 297
    KRAB; krueppel associated box
    COG5048
    Location:397 → 644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567 → 587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593 → 615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237 → 277
    KRAB; KRAB box
    pfam02023
    Location:43 → 130
    SCAN; SCAN domain
    pfam13465
    Location:607 → 632
    zf-H2C2_2; Zinc-finger double domain

  4. XM_005271660.2 → XP_005271717.1  zinc finger protein 202 isoform X1

    See identical proteins and their annotated locations for XP_005271717.1

    UniProtKB/Swiss-Prot
    B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
    Conserved Domains (8) summary
    smart00431
    Location:43 → 153
    SCAN; leucine rich region
    smart00349
    Location:237 → 297
    KRAB; krueppel associated box
    COG5048
    Location:397 → 644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567 → 587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593 → 615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237 → 277
    KRAB; KRAB box
    pfam02023
    Location:43 → 130
    SCAN; SCAN domain
    pfam13465
    Location:607 → 632
    zf-H2C2_2; Zinc-finger double domain

  5. XM_006718901.3 → XP_006718964.1  zinc finger protein 202 isoform X1

    See identical proteins and their annotated locations for XP_006718964.1

    UniProtKB/Swiss-Prot
    B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
    Conserved Domains (8) summary
    smart00431
    Location:43 → 153
    SCAN; leucine rich region
    smart00349
    Location:237 → 297
    KRAB; krueppel associated box
    COG5048
    Location:397 → 644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567 → 587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593 → 615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237 → 277
    KRAB; KRAB box
    pfam02023
    Location:43 → 130
    SCAN; SCAN domain
    pfam13465
    Location:607 → 632
    zf-H2C2_2; Zinc-finger double domain

  6. XM_011542972.2 → XP_011541274.1  zinc finger protein 202 isoform X1

    See identical proteins and their annotated locations for XP_011541274.1

    UniProtKB/Swiss-Prot
    B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
    Conserved Domains (8) summary
    smart00431
    Location:43 → 153
    SCAN; leucine rich region
    smart00349
    Location:237 → 297
    KRAB; krueppel associated box
    COG5048
    Location:397 → 644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567 → 587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593 → 615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237 → 277
    KRAB; KRAB box
    pfam02023
    Location:43 → 130
    SCAN; SCAN domain
    pfam13465
    Location:607 → 632
    zf-H2C2_2; Zinc-finger double domain

  7. XM_011542975.2 → XP_011541277.1  zinc finger protein 202 isoform X1

    See identical proteins and their annotated locations for XP_011541277.1

    UniProtKB/Swiss-Prot
    B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
    Conserved Domains (8) summary
    smart00431
    Location:43 → 153
    SCAN; leucine rich region
    smart00349
    Location:237 → 297
    KRAB; krueppel associated box
    COG5048
    Location:397 → 644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567 → 587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593 → 615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237 → 277
    KRAB; KRAB box
    pfam02023
    Location:43 → 130
    SCAN; SCAN domain
    pfam13465
    Location:607 → 632
    zf-H2C2_2; Zinc-finger double domain

  8. XM_011542973.2 → XP_011541275.1  zinc finger protein 202 isoform X1

    See identical proteins and their annotated locations for XP_011541275.1

    UniProtKB/Swiss-Prot
    B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
    Conserved Domains (8) summary
    smart00431
    Location:43 → 153
    SCAN; leucine rich region
    smart00349
    Location:237 → 297
    KRAB; krueppel associated box
    COG5048
    Location:397 → 644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567 → 587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593 → 615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237 → 277
    KRAB; KRAB box
    pfam02023
    Location:43 → 130
    SCAN; SCAN domain
    pfam13465
    Location:607 → 632
    zf-H2C2_2; Zinc-finger double domain

  9. XM_047427564.1 → XP_047283520.1  zinc finger protein 202 isoform X1

    UniProtKB/Swiss-Prot
    B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    123752703..123770446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369893.1 → XP_054225868.1  zinc finger protein 202 isoform X1

  2. XM_054369892.1 → XP_054225867.1  zinc finger protein 202 isoform X1

  3. XM_054369895.1 → XP_054225870.1  zinc finger protein 202 isoform X1

  4. XM_054369896.1 → XP_054225871.1  zinc finger protein 202 isoform X1

  5. XM_054369898.1 → XP_054225873.1  zinc finger protein 202 isoform X1

  6. XM_054369891.1 → XP_054225866.1  zinc finger protein 202 isoform X1

  7. XM_054369897.1 → XP_054225872.1  zinc finger protein 202 isoform X1

  8. XM_054369894.1 → XP_054225869.1  zinc finger protein 202 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95125.4 GenPept UniProtKB/Swiss-Prot:O95125

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