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ZNF8 zinc finger protein 8 [ Homo sapiens (human) ]

Gene ID: 7554, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF8provided by HGNC
Official Full Name
zinc finger protein 8provided by HGNC
Primary source
HGNC:HGNC:13154
See related
Ensembl:ENSG00000278129 MIM:194532; AllianceGenome:HGNC:13154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HF.18; Zfp128
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within BMP signaling pathway. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 2.9), bone marrow (RPKM 2.3) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
19q13.43
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58278955..58302791)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61375360..61399206)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58790321..58814157)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 436 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58740156-58740982 Neighboring gene zinc finger protein 544 Neighboring gene ZNF8 divergent transcript Neighboring gene ZNF8-ERVK3-1 readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15183 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58816949-58817449 Neighboring gene Sharpr-MPRA regulatory region 7439 Neighboring gene endogenous retrovirus group K3 member 1 Neighboring gene uncharacterized LOC105372480 Neighboring gene zinc finger protein 470 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes. Lania L, et al. Genomics, 1990 Feb. PMID 2106481
  2. ZNF8-miR-552-5p Axis Modulates ACSL4-Mediated Ferroptosis in Hepatocellular Carcinoma. Yang H, et al. DNA Cell Biol, 2023 Jun. PMID 37126948
  3. Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. Jiao K, et al. Mol Cell Biol, 2002 Nov. PMID 12370310, Free PMC Article
  4. Analysis of the human HP1 interactome reveals novel binding partners. Rosnoblet C, et al. Biochem Biophys Res Commun, 2011 Sep 23. PMID 21888893
  5. The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis. Funato Y, et al. Dev Cell, 2020 Nov 23. PMID 32918875

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF8-miR-552-5p Axis Modulates ACSL4-Mediated Ferroptosis in Hepatocellular Carcinoma.
    Title: ZNF8-miR-552-5p Axis Modulates ACSL4-Mediated Ferroptosis in Hepatocellular Carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough ZNF8-ERVK3-1

Readthrough gene: ZNF8-ERVK3-1, Included gene: ERVK3-1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 8
Names
zinc finger protein 272
zinc finger protein 8 (clone HF.18)
zinc finger protein HF.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021089.3 → NP_066575.2  zinc finger protein 8

    See identical proteins and their annotated locations for NP_066575.2

    Status: VALIDATED

    Source sequence(s)
    AC020915, AK093110, AK225825
    Consensus CDS
    CCDS12974.1
    UniProtKB/Swiss-Prot
    P17098, Q6PI99
    UniProtKB/TrEMBL
    B3KS94
    Related
    ENSP00000477716.1, ENST00000621650.2
    Conserved Domains (4) summary
    smart00349
    Location:25 → 85
    KRAB; krueppel associated box
    COG5048
    Location:167 → 404
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:467 → 489
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    58278955..58302791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    61375360..61399206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17098.2 GenPept UniProtKB/Swiss-Prot:P17098

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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