TRPV1 transient receptor potential cation channel subfamily V member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRPV1provided by HGNC
Official Full Name: transient receptor potential cation channel subfamily V member 1provided by HGNC
Primary source: HGNC:HGNC:12716
See related: Ensembl:ENSG00000196689 MIM:602076; AllianceGenome:HGNC:12716
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: VR1
Summary: Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in duodenum (RPKM 3.6), ovary (RPKM 3.0) and 25 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 17p13.2

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (3565446..3609411, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (3454482..3498442, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (3468740..3512705, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRPV1: Receptor structure, activation, modulation and role in neuro-immune interactions and pain.
Title: TRPV1: Receptor structure, activation, modulation and role in neuro-immune interactions and pain.
LncRNA SNHG1 alleviates myocardial ischaemia-reperfusion injury by regulating the miR-137-3p/KLF4/TRPV1 axis.
Title: LncRNA SNHG1 alleviates myocardial ischaemia-reperfusion injury by regulating the miR-137-3p/KLF4/TRPV1 axis.
Low-Level miR-199 Contribute to Neuropathic Low Back Pain via TRPV1 by Regulating the Production of Pro-Inflammatory Cytokines on Macrophage.
Title: Low-Level miR-199 Contribute to Neuropathic Low Back Pain via TRPV1 by Regulating the Production of Pro-Inflammatory Cytokines on Macrophage.
Relation Between Reactive Oxygen Species Production and Transient Receptor Potential Vanilloid1 Expression in Human Skin During Aging.
Title: Relation Between Reactive Oxygen Species Production and Transient Receptor Potential Vanilloid1 Expression in Human Skin During Aging.
Transient receptor potential vanilloid 1: A potential therapeutic target for the treatment of osteoarthritis and rheumatoid arthritis.
Title: Transient receptor potential vanilloid 1: A potential therapeutic target for the treatment of osteoarthritis and rheumatoid arthritis.
20-HETE mediated TRPV1 activation drives allokinesis via MrgprA3[+] neurons in chronic dermatitis.
Title: 20-HETE mediated TRPV1 activation drives allokinesis via MrgprA3(+) neurons in chronic dermatitis.
TRPV1 Channel in Human Eosinophils: Functional Expression and Inflammatory Modulation.
Title: TRPV1 Channel in Human Eosinophils: Functional Expression and Inflammatory Modulation.
Salt-Taste Polymorphism TRPV1-rs8065080 Is Associated with Increased Likelihood of Depression in an Elderly Cohort.
Title: Salt-Taste Polymorphism TRPV1-rs8065080 Is Associated with Increased Likelihood of Depression in an Elderly Cohort.
TRPV1 enhances cholecystokinin signaling in primary vagal afferent neurons and mediates the central effects on spontaneous glutamate release in the NTS.
Title: TRPV1 enhances cholecystokinin signaling in primary vagal afferent neurons and mediates the central effects on spontaneous glutamate release in the NTS.
Bortezomib-induced neuropathy is in part mediated by the sensitization of TRPV1 channels.
Title: Bortezomib-induced neuropathy is in part mediated by the sensitization of TRPV1 channels.

Submit: New GeneRIF Correction See all GeneRIFs (434)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D17S2148 (e-PCR)
- UniSTS:65069

SHGC-33478 (e-PCR)
- UniSTS:82500

STS-T82277 (e-PCR)
- UniSTS:51300

SHGC-132503 (e-PCR)
- UniSTS:173931

SHGC-147347 (e-PCR)
- UniSTS:175756

RH94216 (e-PCR)
- UniSTS:92583

SHGC-33552 (e-PCR)
- UniSTS:59056

L18441 (e-PCR)
- UniSTS:71348

D17S683 (e-PCR)
- UniSTS:147130

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel activity	TAS Traceable Author Statement more info
enables calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables chloride channel regulator activity	IEA Inferred from Electronic Annotation more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables extracellular ligand-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables intracellularly gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables temperature-gated ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated calcium channel activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in behavioral response to pain	IEA Inferred from Electronic Annotation more info
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transmembrane transport	TAS Traceable Author Statement more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to ATP	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to acidic pH	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to alkaloid	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nerve growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to temperature stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in chemosensory behavior	TAS Traceable Author Statement more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of pain	IEA Inferred from Electronic Annotation more info
involved_in detection of temperature stimulus involved in sensory perception of pain	IEA Inferred from Electronic Annotation more info
involved_in detection of temperature stimulus involved in thermoception	IEA Inferred from Electronic Annotation more info
involved_in diet induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in fever generation	IEA Inferred from Electronic Annotation more info
involved_in glutamate secretion	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in microglial cell activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of establishment of blood-brain barrier	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of heart rate	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitochondrial membrane potential	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in peptide secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to capsazepine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to capsazepine	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to peptide hormone	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle contraction involved in micturition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thermoception	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in dendritic spine membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: transient receptor potential cation channel subfamily V member 1

Names: OTRPC1; capsaicin receptor; osm-9-like TRP channel 1; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; vanilloid receptor subtype 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029716.2 RefSeqGene

Range

5000..48965

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_018727.5 → NP_061197.4 transient receptor potential cation channel subfamily V member 1

See identical proteins and their annotated locations for NP_061197.4

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains a different segment in the 5' UTR, compared to variant 3. Variants 1-4 all encode the same protein.

Source sequence(s)

AC027796, AF196175, AJ272063, AL136801

Consensus CDS

CCDS45576.1

UniProtKB/Swiss-Prot

A2RUA9, Q3LU47, Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22

UniProtKB/TrEMBL

Q09HS5

Related

ENSP00000461007.1, ENST00000571088.5

Conserved Domains (3) summary

cd00204
Location:200 → 354

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:52 → 825

trp; transient-receptor-potential calcium channel protein

sd00045
Location:202 → 232

ANK; ANK repeat [structural motif]
NM_080704.4 → NP_542435.2 transient receptor potential cation channel subfamily V member 1

See identical proteins and their annotated locations for NP_542435.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) contains a different segment in the 5' UTR, compared to variant 3. Variants 1-4 all encode the same protein.

Source sequence(s)

AC027796, AF196175, AJ272063, AL136801

Consensus CDS

CCDS45576.1

UniProtKB/Swiss-Prot

A2RUA9, Q3LU47, Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22

UniProtKB/TrEMBL

Q09HS5

Related

ENSP00000459962.1, ENST00000572705.2

Conserved Domains (3) summary

cd00204
Location:200 → 354

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:52 → 825

trp; transient-receptor-potential calcium channel protein

sd00045
Location:202 → 232

ANK; ANK repeat [structural motif]
NM_080705.4 → NP_542436.2 transient receptor potential cation channel subfamily V member 1

See identical proteins and their annotated locations for NP_542436.2

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains a different segment in the 5' UTR, compared to variant 3. Variants 1-4 all encode the same protein.

Source sequence(s)

AC027796, AF196175, AJ272063, AL136801

Consensus CDS

CCDS45576.1

UniProtKB/Swiss-Prot

A2RUA9, Q3LU47, Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22

UniProtKB/TrEMBL

Q09HS5

Related

ENSP00000382661.3, ENST00000399759.7

Conserved Domains (3) summary

cd00204
Location:200 → 354

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:52 → 825

trp; transient-receptor-potential calcium channel protein

sd00045
Location:202 → 232

ANK; ANK repeat [structural motif]
NM_080706.3 → NP_542437.2 transient receptor potential cation channel subfamily V member 1

See identical proteins and their annotated locations for NP_542437.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents the longest transcript. Variants 1-4 all encode the same protein.

Source sequence(s)

AC027796, AF196175, AJ272063, AJ277028, AL136801

Consensus CDS

CCDS45576.1

UniProtKB/Swiss-Prot

A2RUA9, Q3LU47, Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22

UniProtKB/TrEMBL

Q09HS5

Related

ENSP00000382659.4, ENST00000399756.8

Conserved Domains (3) summary

cd00204
Location:200 → 354

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:52 → 825

trp; transient-receptor-potential calcium channel protein

sd00045
Location:202 → 232

ANK; ANK repeat [structural motif]