VEGFB vascular endothelial growth factor B [Homo sapiens (human)] - Gene

Summary

Official Symbol: VEGFBprovided by HGNC
Official Full Name: vascular endothelial growth factor Bprovided by HGNC
Primary source: HGNC:HGNC:12681
See related: Ensembl:ENSG00000173511 MIM:601398; AllianceGenome:HGNC:12681
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: VRF; VEGFL
Summary: This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]
Expression: Broad expression in fat (RPKM 106.2), heart (RPKM 26.1) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (64234584..64239264)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (64224529..64229291)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (64002056..64006736)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway.
Title: VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway.
Increased Serum VEGF-B Level Is Associated With Renal Function Impairment in Patients With Type 2 Diabetes.
Title: Increased Serum VEGF-B Level Is Associated With Renal Function Impairment in Patients With Type 2 Diabetes.
The Aryl Hydrocarbon Receptor-Dependent TGF-alpha/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis.
Title: The Aryl Hydrocarbon Receptor-Dependent TGF-α/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis.
Peptides Derived from Vascular Endothelial Growth Factor B Show Potent Binding to Neuropilin-1.
Title: Peptides Derived from Vascular Endothelial Growth Factor B Show Potent Binding to Neuropilin-1.
Co-expression of VEGF-B and FLT-1 correlates with malignancy and prognosis of gastric cancer.
Title: Co-expression of VEGF-B and FLT-1 correlates with malignancy and prognosis of gastric cancer.
Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application.
Title: Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application.
Identification of a Tumor Microenvironment-relevant Gene set-based Prognostic Signature and Related Therapy Targets in Gastric Cancer.
Title: Identification of a Tumor Microenvironment-relevant Gene set-based Prognostic Signature and Related Therapy Targets in Gastric Cancer.
Results found that VEGF-B expressions levels were higher in Behcet's disease (BD) patients than those in the healthy group, but this difference did not reach statistical significance. Also, VEGF-B gene expression is significantly higher in patients with vascular involvement (DVT/thrombophlebitis).
Title: The Evaluation of the Relationship between sTREM-1, VEGF-B, and VEGF Gene Expression Levels with Disease Activity of Behçet's Patients.
vitreous levels increased in neovascular retinal diseases
Title: Evaluation of the growth factors VEGF-a and VEGF-B in the vitreous and serum of patients with macular and retinal vascular diseases.
High plasma VEGF-B levels are associated with type 2 diabetes mellitus.
Title: Plasma vascular endothelial growth factor B levels are increased in patients with newly diagnosed type 2 diabetes mellitus and associated with the first phase of glucose-stimulated insulin secretion function of β-cell.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates members of the PDGF/VEGF growth factor family (PDGFA, VEGFA,VEGFB, VEGFC) in mammary epithelial cells	PubMed
	tat	HIV-1 Tat enhances vIL-6-induced angiogenesis and tumorigenesis of fibroblasts and human endothelial cells, which correlates with upregulation of CD31, CD34, SMA, VEGF, b-FGF, and cyclin D1 expression	PubMed
	tat	HIV-1 Tat enhances Kaposi's sarcoma-associated herpesvirus vIL-6-induced cell proliferation, cellular transformation, vascular tube formation, and VEGF production in tumor cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-82715 (e-PCR)
- UniSTS:102424

RH79811 (e-PCR)
- UniSTS:87068

WI-14122 (e-PCR)
- UniSTS:30760

RH27714 (e-PCR)
- UniSTS:88669

WI-16915 (e-PCR)
- UniSTS:39079

G33073 (e-PCR)
- UniSTS:48851

RH41986 (e-PCR)
- UniSTS:70122

VEGFB_2536 (e-PCR)
- UniSTS:281074

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables vascular endothelial growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in coronary vasculature development	IEA Inferred from Electronic Annotation more info
involved_in induction of positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mast cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein O-linked glycosylation	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info
involved_in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in platelet alpha granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: vascular endothelial growth factor B

Names: VEGF-related factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029823.1 RefSeqGene

Range

5001..9681

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001243733.2 → NP_001230662.1 vascular endothelial growth factor B isoform VEGFB-167 precursor

See identical proteins and their annotated locations for NP_001230662.1

Status: REVIEWED

Description

Transcript Variant: This variant (VEGFB-167) lacks a segment in the 3' coding region, resulting in a downstream stop codon, compared to variant VEGFB-186. The resulting isoform (VEGFB-167, also known as VRF167) has a shorter and distinct C-terminus, compared to isoform VEGFB-186. This isoform contains the heparin binding domain and is mostly sequestered in the extracellular matrix.

Source sequence(s)

AP001453, BG031449, BM694361, BU730521, U48801

Consensus CDS

CCDS58144.1

UniProtKB/TrEMBL

Q8TEV2

Related

ENSP00000401550.2, ENST00000426086.3

Conserved Domains (1) summary

smart00141
Location:45 → 126

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
NM_003377.5 → NP_003368.1 vascular endothelial growth factor B isoform VEGFB-186 precursor

See identical proteins and their annotated locations for NP_003368.1

Status: REVIEWED

Description

Transcript Variant: This variant (VEGFB-186) encodes the longer isoform (VEGFB-186, also known as VRF186). This isoform lacks the heparin binding domain and is secreted freely from cells.

Source sequence(s)

AP001453, BC008818, BM694361, BU730521

Consensus CDS

CCDS8062.1

UniProtKB/Swiss-Prot

P49765, Q16528

UniProtKB/TrEMBL

Q7LAP4

Related

ENSP00000311127.2, ENST00000309422.7

Conserved Domains (2) summary

PHA03269
Location:108 → 188

PHA03269; envelope glycoprotein C; Provisional

smart00141
Location:45 → 126

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family