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USF2 upstream transcription factor 2, c-fos interacting [ Homo sapiens (human) ]

Gene ID: 7392, updated on 3-Apr-2024

Summary

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Official Symbol
USF2provided by HGNC
Official Full Name
upstream transcription factor 2, c-fos interactingprovided by HGNC
Primary source
HGNC:HGNC:12594
See related
Ensembl:ENSG00000105698 MIM:600390; AllianceGenome:HGNC:12594
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FIP; bHLHb12
Summary
This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in fat (RPKM 22.6), spleen (RPKM 20.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19q13.12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35268962..35279821)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37813633..37824489)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35759865..35770724)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 187, member B pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14461 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35738792-35739594 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35739595-35740396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35748323-35748823 Neighboring gene uncharacterized LOC105372380 Neighboring gene lipolysis stimulated lipoprotein receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35753027-35753725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14462 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35761221-35761960 Neighboring gene HNF4 motif-containing MPRA enhancer 344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35773293-35773802 Neighboring gene hepcidin antimicrobial peptide Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14466 Neighboring gene myelin associated glycoprotein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35795633-35796520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35802349-35802850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35802851-35803350

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. USF2 knockdown downregulates THBS1 to inhibit the TGF-β signaling pathway and reduce pyroptosis in sepsis-induced acute kidney injury. Sun J, et al. Pharmacol Res, 2022 Feb. PMID 34756923
  2. Irrelevance of USF2 rs916145 polymorphism with the risk of biliary atresia susceptibility in Southern Chinese children. Chen L, et al. Biosci Rep, 2020 Feb 28. PMID 32109289, Free PMC Article
  3. High glucose upregulates upstream stimulatory factor 2 in human renal proximal tubular cells through angiotensin II-dependent activation of CREB. Visavadiya NP, et al. Nephron Exp Nephrol, 2011. PMID 20814220, Free PMC Article
  4. Isolation of a novel USF2 isoform: repressor of cathepsin B expression. Yan S, et al. Gene, 2004 Aug 4. PMID 15276216
  5. USF2 is connected to GAAAATATGATA element and associates with androgen receptor-dependent transcriptional regulation in prostate. Kivinen A, et al. Prostate, 2004 May 1. PMID 15042619

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA X-Inactive Specific Transcript (XIST) interacting with USF2 promotes osteogenic differentiation of periodontal ligament stem cells through regulation of WDR72 transcription.
    Title: Long non-coding RNA X-Inactive Specific Transcript (XIST) interacting with USF2 promotes osteogenic differentiation of periodontal ligament stem cells through regulation of WDR72 transcription.
  2. WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A.
    Title: WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A.
  3. USF2-mediated upregulation of TXNRD1 contributes to hepatocellular carcinoma progression by activating Akt/mTOR signaling.
    Title: USF2-mediated upregulation of TXNRD1 contributes to hepatocellular carcinoma progression by activating Akt/mTOR signaling.
  4. Upstream stimulatory factor 2 inhibits erastin-induced ferroptosis in pancreatic cancer through transcriptional regulation of pyruvate kinase M2.
    Title: Upstream stimulatory factor 2 inhibits erastin-induced ferroptosis in pancreatic cancer through transcriptional regulation of pyruvate kinase M2.
  5. USF2 knockdown downregulates THBS1 to inhibit the TGF-beta signaling pathway and reduce pyroptosis in sepsis-induced acute kidney injury.
    Title: USF2 knockdown downregulates THBS1 to inhibit the TGF-β signaling pathway and reduce pyroptosis in sepsis-induced acute kidney injury.
  6. USF2 reduces BMP3 expression via transcriptional activation of miR-34a, thus promoting osteogenic differentiation of BMSCs.
    Title: USF2 reduces BMP3 expression via transcriptional activation of miR-34a, thus promoting osteogenic differentiation of BMSCs.
  7. Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen.
    Title: Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen.
  8. Irrelevance of USF2 rs916145 polymorphism with the risk of biliary atresia susceptibility in Southern Chinese children.
    Title: Irrelevance of USF2 rs916145 polymorphism with the risk of biliary atresia susceptibility in Southern Chinese children.
  9. USF2 and ATF4 were upregulated in the osteogenic differentiation of periodontal ligament cells
    Title: USF2 enhances the osteogenic differentiation of PDLCs by promoting ATF4 transcriptional activities.
  10. This study reported that USF2 (upstream stimulatory factor 2), a basic helix-loop-helix-leucine-zip transcription factor, is necessary for the transcriptional activity of Smurf1 and Smurf2.
    Title: USF2 inhibits the transcriptional activity of Smurf1 and Smurf2 to promote breast cancer tumorigenesis.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bHLH transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in lactation IEA
Inferred from Electronic Annotation
more info
  
involved_in late viral transcription IC
Inferred by Curator
more info
 PubMed 
involved_in lipid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription from RNA polymerase II promoter by glucose IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
upstream stimulatory factor 2
Names
c-fos interacting protein
class B basic helix-loop-helix protein 12
major late transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029241.1 RefSeqGene

    Range
    4970..15829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321150.2 → NP_001308079.1  upstream stimulatory factor 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AD000684, AI240594, AY147880
    Consensus CDS
    CCDS82329.1
    UniProtKB/Swiss-Prot
    Q15853
    Related
    ENSP00000368429.3, ENST00000379134.7
    Conserved Domains (2) summary
    cd00083
    Location:102 → 164
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    TIGR04211
    Location:135 → 202
    SH3_and_anchor; SH3 domain protein

  2. NM_003367.4 → NP_003358.1  upstream stimulatory factor 2 isoform 1

    See identical proteins and their annotated locations for NP_003358.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AD000684, AI240594, AY007087, BC049821, X90825
    Consensus CDS
    CCDS12452.1
    UniProtKB/Swiss-Prot
    O00671, O00709, Q05750, Q07952, Q15851, Q15852, Q15853, Q6FI33, Q6YI47
    UniProtKB/TrEMBL
    B4DLJ1
    Related
    ENSP00000222305.2, ENST00000222305.8
    Conserved Domains (2) summary
    cd18923
    Location:229 → 308
    bHLHzip_USF2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins
    pfam06005
    Location:290 → 334
    ZapB; Cell division protein ZapB

  3. NM_207291.3 → NP_997174.1  upstream stimulatory factor 2 isoform 2

    See identical proteins and their annotated locations for NP_997174.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AD000684, AI240594, AY007087, X90825
    Consensus CDS
    CCDS12453.1
    UniProtKB/Swiss-Prot
    Q15853
    Related
    ENSP00000340633.4, ENST00000343550.9
    Conserved Domains (2) summary
    cd18923
    Location:162 → 241
    bHLHzip_USF2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins
    pfam06005
    Location:223 → 267
    ZapB; Cell division protein ZapB

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    35268962..35279821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259197.5 → XP_005259254.1  upstream stimulatory factor 2 isoform X1

    UniProtKB/TrEMBL
    B4DLJ1
    Related
    ENSP00000471511.1, ENST00000594064.5
    Conserved Domains (1) summary
    cd18923
    Location:229 → 308
    bHLHzip_USF2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins

  2. XM_011527260.3 → XP_011525562.1  upstream stimulatory factor 2 isoform X2

  3. XM_011527261.3 → XP_011525563.1  upstream stimulatory factor 2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    37813633..37824489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321938.1 → XP_054177913.1  upstream stimulatory factor 2 isoform X1

  2. XM_054321939.1 → XP_054177914.1  upstream stimulatory factor 2 isoform X2

  3. XM_054321940.1 → XP_054177915.1  upstream stimulatory factor 2 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15853.1 GenPept UniProtKB/Swiss-Prot:Q15853

Gene LinkOut

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