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UCHL3 ubiquitin C-terminal hydrolase L3 [ Homo sapiens (human) ]

Gene ID: 7347, updated on 3-Apr-2024

Summary

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Official Symbol
UCHL3provided by HGNC
Official Full Name
ubiquitin C-terminal hydrolase L3provided by HGNC
Primary source
HGNC:HGNC:12515
See related
Ensembl:ENSG00000118939 MIM:603090; AllianceGenome:HGNC:12515
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UCH-L3
Summary
The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in thyroid (RPKM 5.1), testis (RPKM 4.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
13q22.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (75549502..75606020)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (74773163..74829671)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (76123638..76180156)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7821 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:75899800-75900999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7822 Neighboring gene TBC1 domain family member 4 Neighboring gene Sharpr-MPRA regulatory region 11619 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:75935886-75936406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5401 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7829 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:76123825-76124385 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7830 Neighboring gene COMM domain containing 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:76200739-76200877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5403 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5405 Neighboring gene LMO7 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7834 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:76259126-76259626 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:76259627-76260127 Neighboring gene LIM domain 7 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr13:76279181-76280380 Neighboring gene family with sequence similarity 204 member C, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7835 Neighboring gene NANOG hESC enhancer GRCh37_chr13:76377179-76377853 Neighboring gene NANOG hESC enhancer GRCh37_chr13:76399228-76399729 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5406 Neighboring gene LMO7DN intronic transcript 1 Neighboring gene LMO7 downstream neighbor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Rational Development and Characterization of a Ubiquitin Variant with Selectivity for Ubiquitin C-Terminal Hydrolase L3. Hewitt CS, et al. Biomolecules, 2022 Jan 1. PMID 35053210, Free PMC Article
  2. Silencing UCHL3 enhances radio-sensitivity of non-small cell lung cancer cells by inhibiting DNA repair. Liu M, et al. Aging (Albany NY), 2021 May 19. PMID 34016790, Free PMC Article
  3. UCHL3 promotes aerobic glycolysis of pancreatic cancer through upregulating LDHA expression. Fan Y, et al. Clin Transl Oncol, 2021 Aug. PMID 33616859
  4. UCH-L3 promotes non-small cell lung cancer proliferation via accelerating cell cycle and inhibiting cell apoptosis. Li G, et al. Biotechnol Appl Biochem, 2021 Feb. PMID 32180254
  5. [UCH-L3 Expression in Epithelial Ovarian Cancer and Its Clinical Significance]. Li TT, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2019 Jul. PMID 31642235

See all (104) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UCHL-3 as a potential biomarker of ovarian cancer.
    Title: UCHL-3 as a potential biomarker of ovarian cancer.
  2. CircMTA2 Drives Gastric Cancer Progression through Suppressing MTA2 Degradation via Interacting with UCHL3.
    Title: CircMTA2 Drives Gastric Cancer Progression through Suppressing MTA2 Degradation via Interacting with UCHL3.
  3. UCHL3 inhibits ferroptosis by stabilizing beta-catenin and maintains stem-like properties of hepatocellular carcinoma cells.
    Title: UCHL3 inhibits ferroptosis by stabilizing β-catenin and maintains stem-like properties of hepatocellular carcinoma cells.
  4. Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression.
    Title: Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression.
  5. The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis.
    Title: The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis.
  6. Rational Development and Characterization of a Ubiquitin Variant with Selectivity for Ubiquitin C-Terminal Hydrolase L3.
    Title: Rational Development and Characterization of a Ubiquitin Variant with Selectivity for Ubiquitin C-Terminal Hydrolase L3.
  7. Knockdown of UCHL3 inhibits esophageal squamous cell carcinoma progression by reducing CRY2 methylation.
    Title: Knockdown of UCHL3 inhibits esophageal squamous cell carcinoma progression by reducing CRY2 methylation.
  8. UCHL3 promotes aerobic glycolysis of pancreatic cancer through upregulating LDHA expression.
    Title: UCHL3 promotes aerobic glycolysis of pancreatic cancer through upregulating LDHA expression.
  9. The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor.
    Title: The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor.
  10. K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap.
    Title: K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study in a Chinese population with diabetic retinopathy.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables deNEDDylase activity TAS
Traceable Author Statement
more info
  
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in post-translational protein modification TAS
Traceable Author Statement
more info
  
involved_in protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination TAS
Traceable Author Statement
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase isozyme L3
Names
testicular tissue protein Li 221
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
ubiquitin thioesterase L3
ubiquitin thiolesterase
NP_001257881.1
NP_005993.1
XP_011533514.1
XP_011533515.1
XP_011533516.1
XP_016876214.1
XP_016876215.1
XP_016876216.1
XP_047286538.1
XP_047286539.1
XP_054230891.1
XP_054230892.1
XP_054230893.1
XP_054230894.1
XP_054230895.1
XP_054230896.1
XP_054230897.1
XP_054230898.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270952.2 → NP_001257881.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 1

    See identical proteins and their annotated locations for NP_001257881.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    AA234624, AL137244, BC018125, BQ427804
    Consensus CDS
    CCDS73586.1
    Conserved Domains (1) summary
    cd09616
    Location:1 → 191
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

  2. NM_006002.5 → NP_005993.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 2

    See identical proteins and their annotated locations for NP_005993.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AA234624, BC018125
    Consensus CDS
    CCDS9453.1
    UniProtKB/Swiss-Prot
    B2R970, P15374, Q5TBK8, Q6IBE9
    UniProtKB/TrEMBL
    A0A140VJZ4
    Related
    ENSP00000366819.3, ENST00000377595.8
    Conserved Domains (1) summary
    cd09616
    Location:6 → 227
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    75549502..75606020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535214.3 → XP_011533516.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X4

    See identical proteins and their annotated locations for XP_011533516.1

    UniProtKB/TrEMBL
    Q5TBK7
    Related
    ENSP00000398189.1, ENST00000419068.1
    Conserved Domains (1) summary
    cd09616
    Location:1 → 255
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

  2. XM_011535212.2 → XP_011533514.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X1

    Conserved Domains (1) summary
    cd09616
    Location:6 → 291
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

  3. XM_011535213.3 → XP_011533515.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X2

    Conserved Domains (1) summary
    cd09616
    Location:6 → 287
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

  4. XM_017020727.2 → XP_016876216.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X6

    Conserved Domains (1) summary
    cd09616
    Location:6 → 223
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

  5. XM_017020725.2 → XP_016876214.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X3

  6. XM_047430582.1 → XP_047286538.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X7

  7. XM_017020726.2 → XP_016876215.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X5

  8. XM_047430583.1 → XP_047286539.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    74773163..74829671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374919.1 → XP_054230894.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X4

  2. XM_054374916.1 → XP_054230891.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X1

  3. XM_054374917.1 → XP_054230892.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X2

  4. XM_054374921.1 → XP_054230896.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X6

  5. XM_054374918.1 → XP_054230893.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X3

  6. XM_054374922.1 → XP_054230897.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X7

  7. XM_054374920.1 → XP_054230895.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X5

  8. XM_054374923.1 → XP_054230898.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15374.1 GenPept UniProtKB/Swiss-Prot:P15374

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