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TRPC3 transient receptor potential cation channel subfamily C member 3 [ Homo sapiens (human) ]

Gene ID: 7222, updated on 3-Apr-2024

Summary

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Official Symbol
TRPC3provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily C member 3provided by HGNC
Primary source
HGNC:HGNC:12335
See related
Ensembl:ENSG00000138741 MIM:602345; AllianceGenome:HGNC:12335
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRP3; SCA41
Summary
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See TRPC3 in Genome Data Viewer
Location:
4q27
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (121874481..121952060, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (125178529..125256098, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (122795636..122873215, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Bardet-Biedl syndrome 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21872 Neighboring gene BBS7 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15661 Neighboring gene uncharacterized LOC102724158 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15662 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21873 Neighboring gene Sharpr-MPRA regulatory region 11420 Neighboring gene uncharacterized LOC112268469 Neighboring gene RNA, 7SL, cytoplasmic 335, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Rs11726196 Single-Nucleotide Polymorphism of the Transient Receptor Potential Canonical 3 (TRPC3) Gene Is Associated with Chronic Pain. Aoki Y, et al. Int J Mol Sci, 2023 Jan 5. PMID 36674543, Free PMC Article
  2. TRPC3 governs the spatiotemporal organization of cellular Ca(2+) signatures by functional coupling to IP(3) receptors. Curcic S, et al. Cell Calcium, 2022 Dec. PMID 36375273
  3. Lysophosphatidic Acid Promotes the Expansion of Cancer Stem Cells via TRPC3 Channels in Triple-Negative Breast Cancer. Hirata N, et al. Int J Mol Sci, 2022 Feb 10. PMID 35216080, Free PMC Article
  4. TRPC3 shapes the ER-mitochondria Ca(2+) transfer characterizing tumour-promoting senescence. Farfariello V, et al. Nat Commun, 2022 Feb 17. PMID 35177596, Free PMC Article
  5. Expression of TRPC3 in cortical lesions from patients with focal cortical dysplasia. Liang C, et al. Neurosci Lett, 2020 Apr 17. PMID 32135163

See all (151) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. New insights in the renal distribution profile of TRPC3 - Of mice and men.
    Title: New insights in the renal distribution profile of TRPC3 - Of mice and men.
  2. MiRNA-26a-5p inhibits preterm labor initiation by targeting and regulating TRPC3 ion channel protein expression.
    Title: MiRNA-26a-5p inhibits preterm labor initiation by targeting and regulating TRPC3 ion channel protein expression.
  3. Modulation and Regulation of Canonical Transient Receptor Potential 3 (TRPC3) Channels.
    Title: Modulation and Regulation of Canonical Transient Receptor Potential 3 (TRPC3) Channels.
  4. Reduction of TRPC1/TRPC3 mediated Ca[2+]-signaling protects oxidative stress-induced COPD.
    Title: Reduction of TRPC1/TRPC3 mediated Ca(2+)-signaling protects oxidative stress-induced COPD.
  5. TRPC3 Regulates Islet Beta-Cell Insulin Secretion.
    Title: TRPC3 Regulates Islet Beta-Cell Insulin Secretion.
  6. Rs11726196 Single-Nucleotide Polymorphism of the Transient Receptor Potential Canonical 3 (TRPC3) Gene Is Associated with Chronic Pain.
    Title: Rs11726196 Single-Nucleotide Polymorphism of the Transient Receptor Potential Canonical 3 (TRPC3) Gene Is Associated with Chronic Pain.
  7. TRPC3 governs the spatiotemporal organization of cellular Ca[2+] signatures by functional coupling to IP3 receptors.
    Title: TRPC3 governs the spatiotemporal organization of cellular Ca(2+) signatures by functional coupling to IP(3) receptors.
  8. PLAA suppresses ovarian cancer metastasis via METTL3-mediated m(6)A modification of TRPC3 mRNA.
    Title: PLAA suppresses ovarian cancer metastasis via METTL3-mediated m(6)A modification of TRPC3 mRNA.
  9. Irisin mediates beiging of adipose-derived mesenchymal stem cells through binding to TRPC3.
    Title: Irisin mediates beiging of adipose-derived mesenchymal stem cells through binding to TRPC3.
  10. Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
    Title: Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Submit: New GeneRIF Correction See all GeneRIFs (117)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Spinocerebellar ataxia type 41
MedGen: C4225158 OMIM: 616410 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium channel activity TAS
Traceable Author Statement
more info
  
enables calcium-activated cation channel activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol 1,4,5 trisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium ion transmembrane transport TAS
Traceable Author Statement
more info
  
involved_in calcium ion transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in phototransduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of calcium ion transport into cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cardiac muscle hypertrophy in response to stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to ATP IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to calcium ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
short transient receptor potential channel 3
Names
hTrp-3
transient receptor protein 3

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030368.2 RefSeqGene

    Range
    5000..82579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130698.2 → NP_001124170.1  short transient receptor potential channel 3 isoform a

    See identical proteins and their annotated locations for NP_001124170.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC079341, AC108930, AY865574, Y13758
    Consensus CDS
    CCDS47130.1
    UniProtKB/Swiss-Prot
    A7VJS1, E9PCJ9, O00593, Q13507, Q15660, Q52M35, Q5G1L5
    UniProtKB/TrEMBL
    J3QTB0
    Related
    ENSP00000368966.3, ENST00000379645.8
    Conserved Domains (4) summary
    cd00204
    Location:119 → 253
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:96 → 890
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:267 → 326
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:146 → 177
    ANK; ANK repeat [structural motif]

  2. NM_001366479.2 → NP_001353408.1  short transient receptor potential channel 3 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC079341, AC108930
    UniProtKB/TrEMBL
    J3QTB0
    Conserved Domains (2) summary
    TIGR00870
    Location:96 → 862
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:146 → 177
    ANK; ANK repeat [structural motif]

  3. NM_003305.2 → NP_003296.1  short transient receptor potential channel 3 isoform b

    See identical proteins and their annotated locations for NP_003296.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an upstream exon , compared to variant 1, resulting in a different 5' UTR and 5' coding region and translation initiation from an inframe, downstream ATG. The encoded protein (isoform b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AY865574, Y13758
    Consensus CDS
    CCDS3725.1
    UniProtKB/TrEMBL
    J3QTB0
    Related
    ENSP00000264811.5, ENST00000264811.9
    Conserved Domains (2) summary
    TIGR00870
    Location:23 → 817
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:73 → 104
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    121874481..121952060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532218.4 → XP_011530520.1  short transient receptor potential channel 3 isoform X3

    UniProtKB/TrEMBL
    J3QTB0
    Conserved Domains (4) summary
    cd00204
    Location:119 → 253
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:96 → 889
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:267 → 326
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:146 → 177
    ANK; ANK repeat [structural motif]

  2. XM_017008578.3 → XP_016864067.1  short transient receptor potential channel 3 isoform X2

    UniProtKB/TrEMBL
    J3QTB0

  3. XM_011532217.4 → XP_011530519.1  short transient receptor potential channel 3 isoform X1

    UniProtKB/TrEMBL
    J3QTB0
    Conserved Domains (4) summary
    cd00204
    Location:119 → 253
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:96 → 906
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:267 → 326
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:146 → 177
    ANK; ANK repeat [structural motif]

  4. XM_047416117.1 → XP_047272073.1  short transient receptor potential channel 3 isoform X5

  5. XM_047416116.1 → XP_047272072.1  short transient receptor potential channel 3 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    125178529..125256098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350770.1 → XP_054206745.1  short transient receptor potential channel 3 isoform X3

  2. XM_054350769.1 → XP_054206744.1  short transient receptor potential channel 3 isoform X2

  3. XM_054350768.1 → XP_054206743.1  short transient receptor potential channel 3 isoform X1

  4. XM_054350772.1 → XP_054206747.1  short transient receptor potential channel 3 isoform X5

  5. XM_054350771.1 → XP_054206746.1  short transient receptor potential channel 3 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13507.4 GenPept UniProtKB/Swiss-Prot:Q13507

Gene LinkOut

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