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TRPC1 transient receptor potential cation channel subfamily C member 1 [ Homo sapiens (human) ]

Gene ID: 7220, updated on 3-Apr-2024

Summary

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Official Symbol
TRPC1provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily C member 1provided by HGNC
Primary source
HGNC:HGNC:12333
See related
Ensembl:ENSG00000144935 MIM:602343; AllianceGenome:HGNC:12333
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRP1; HTRP-1
Summary
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in ovary (RPKM 4.8), endometrium (RPKM 3.9) and 22 other tissues See more
Orthologs
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Genomic context

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See TRPC1 in Genome Data Viewer
Location:
3q23
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (142724034..142807888)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (145471273..145555131)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (142442876..142526730)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20645 Neighboring gene PLS1 antisense RNA 1 Neighboring gene plastin 1 Neighboring gene RN7SK pseudogene 25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14790 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:142443428-142444294 Neighboring gene Sharpr-MPRA regulatory region 6947 Neighboring gene RNA, U7 small nuclear 47 pseudogene Neighboring gene procollagen C-endopeptidase enhancer 2 Neighboring gene ribosomal protein L8 pseudogene 3 Neighboring gene uncharacterized LOC124909443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14791

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Function of TRPC1 in modulating hepatocellular carcinoma progression. Qi H, et al. Med Oncol, 2023 Feb 16. PMID 36797544
  2. The TRPC1 Channel Forms a PI3K/CaM Complex and Regulates Pancreatic Ductal Adenocarcinoma Cell Proliferation in a Ca(2+)-Independent Manner. Schnipper J, et al. Int J Mol Sci, 2022 Jul 18. PMID 35887266, Free PMC Article
  3. Dysregulated transient receptor potential channel 1 expression and its correlation with clinical features and survival profile in surgical non-small-cell lung cancer patients. Ke C, et al. J Clin Lab Anal, 2022 Mar. PMID 35106847, Free PMC Article
  4. Dual effect of nifedipine on pregnant human myometrium contractility: Implication of TRPC1. Yart L, et al. J Cell Physiol, 2022 Mar. PMID 34988986, Free PMC Article
  5. Correlation between classical transient receptor potential channel 1 gene polymorphism and microalbuminuria in patients with primary hypertension. Zhang Y, et al. Clin Exp Hypertens, 2021 Jul 4. PMID 33877007

See all (196) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of TRPC1 protects against high glucose-induced HUVECs dysfunction by inhibiting oxidative stress.
    Title: Upregulation of TRPC1 protects against high glucose-induced HUVECs dysfunction by inhibiting oxidative stress.
  2. Reduction of TRPC1/TRPC3 mediated Ca[2+]-signaling protects oxidative stress-induced COPD.
    Title: Reduction of TRPC1/TRPC3 mediated Ca(2+)-signaling protects oxidative stress-induced COPD.
  3. Function of TRPC1 in modulating hepatocellular carcinoma progression.
    Title: Function of TRPC1 in modulating hepatocellular carcinoma progression.
  4. TRPC1 channels regulate the activation of pancreatic stellate cells through ERK1/2 and SMAD2 pathways and perpetuate their pressure-mediated activation.
    Title: TRPC1 channels regulate the activation of pancreatic stellate cells through ERK1/2 and SMAD2 pathways and perpetuate their pressure-mediated activation.
  5. NCX1 coupled with TRPC1 to promote gastric cancer via Ca(2+)/AKT/beta-catenin pathway.
    Title: NCX1 coupled with TRPC1 to promote gastric cancer via Ca(2+)/AKT/β-catenin pathway.
  6. The TRPC1 Channel Forms a PI3K/CaM Complex and Regulates Pancreatic Ductal Adenocarcinoma Cell Proliferation in a Ca(2+)-Independent Manner.
    Title: The TRPC1 Channel Forms a PI3K/CaM Complex and Regulates Pancreatic Ductal Adenocarcinoma Cell Proliferation in a Ca(2+)-Independent Manner.
  7. Dual effect of nifedipine on pregnant human myometrium contractility: Implication of TRPC1.
    Title: Dual effect of nifedipine on pregnant human myometrium contractility: Implication of TRPC1.
  8. Dysregulated transient receptor potential channel 1 expression and its correlation with clinical features and survival profile in surgical non-small-cell lung cancer patients.
    Title: Dysregulated transient receptor potential channel 1 expression and its correlation with clinical features and survival profile in surgical non-small-cell lung cancer patients.
  9. Orai1alpha, but not Orai1beta, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells.
    Title: Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells.
  10. Sigma1 Receptor Inhibits TRPC1-Mediated Ca(2+) Entry That Promotes Dopaminergic Cell Death.
    Title: Sigma1 Receptor Inhibits TRPC1-Mediated Ca(2+) Entry That Promotes Dopaminergic Cell Death.
Submit: New GeneRIF Correction See all GeneRIFs (160)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat PI3K/Akt, TRPC, and GSK3 beta signaling pathways are all involved in PDGF-C mediated neuroprotection against HIV-1 Tat in human neuroblastoma cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC133334, MGC133335

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables calcium channel activity TAS
Traceable Author Statement
more info
  
enables inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol 1,4,5 trisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic cation channel activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport TAS
Traceable Author Statement
more info
  
involved_in calcium ion transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in melanin biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cardiac conduction TAS
Traceable Author Statement
more info
  
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to calcium ion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
short transient receptor potential channel 1
Names
capacitative calcium channel protein Trp1
transient receptor potential canonical 1
transient receptor protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030369.1 RefSeqGene

    Range
    4611..88465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001251845.2 → NP_001238774.1  short transient receptor potential channel 1 isoform 1

    See identical proteins and their annotated locations for NP_001238774.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC072028, AI280444, BC112338, X89066
    Consensus CDS
    CCDS58856.1
    UniProtKB/Swiss-Prot
    P48995, Q14CE4
    UniProtKB/TrEMBL
    A7VJS2
    Related
    ENSP00000419313.1, ENST00000476941.6
    Conserved Domains (1) summary
    TIGR00870
    Location:48 → 774
    trp; transient-receptor-potential calcium channel protein

  2. NM_001413361.1 → NP_001400290.1  short transient receptor potential channel 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC022291, AC072028

  3. NM_001413362.1 → NP_001400291.1  short transient receptor potential channel 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC022291, AC072028

  4. NM_001413363.1 → NP_001400292.1  short transient receptor potential channel 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022291, AC072028

  5. NM_001413375.1 → NP_001400304.1  short transient receptor potential channel 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC022291, AC072028

  6. NM_001413376.1 → NP_001400305.1  short transient receptor potential channel 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC022291, AC072028

  7. NM_001413377.1 → NP_001400306.1  short transient receptor potential channel 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022291, AC072028

  8. NM_001413378.1 → NP_001400307.1  short transient receptor potential channel 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC022291, AC072028

  9. NM_001413379.1 → NP_001400308.1  short transient receptor potential channel 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC022291, AC072028

  10. NM_001413380.1 → NP_001400309.1  short transient receptor potential channel 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022291, AC072028

  11. NM_001413381.1 → NP_001400310.1  short transient receptor potential channel 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC022291, AC072028

  12. NM_001413382.1 → NP_001400311.1  short transient receptor potential channel 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022291, AC072028

  13. NM_001413383.1 → NP_001400312.1  short transient receptor potential channel 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC022291, AC072028

  14. NM_001413384.1 → NP_001400313.1  short transient receptor potential channel 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC022291, AC072028

  15. NM_001413385.1 → NP_001400314.1  short transient receptor potential channel 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC022291, AC072028

  16. NM_001413386.1 → NP_001400315.1  short transient receptor potential channel 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC022291, AC072028

  17. NM_003304.5 → NP_003295.1  short transient receptor potential channel 1 isoform 2

    See identical proteins and their annotated locations for NP_003295.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC072028, BX331349, DB185459, X89066
    Consensus CDS
    CCDS3126.1
    UniProtKB/TrEMBL
    A7VJS2
    Related
    ENSP00000273482.6, ENST00000273482.10
    Conserved Domains (2) summary
    TIGR00870
    Location:48 → 740
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:83 → 117
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    142724034..142807888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448842.1 → XP_047304798.1  short transient receptor potential channel 1 isoform X5

  2. XM_047448840.1 → XP_047304796.1  short transient receptor potential channel 1 isoform X3

  3. XM_047448841.1 → XP_047304797.1  short transient receptor potential channel 1 isoform X4

  4. XM_017007121.3 → XP_016862610.1  short transient receptor potential channel 1 isoform X1

    UniProtKB/TrEMBL
    A7VJS2
    Conserved Domains (1) summary
    TIGR00870
    Location:2 → 713
    trp; transient-receptor-potential calcium channel protein

  5. XM_047448839.1 → XP_047304795.1  short transient receptor potential channel 1 isoform X2

RNA

  1. XR_007095723.1 RNA Sequence

  2. XR_007095722.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    145471273..145555131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347736.1 → XP_054203711.1  short transient receptor potential channel 1 isoform X5

  2. XM_054347734.1 → XP_054203709.1  short transient receptor potential channel 1 isoform X3

  3. XM_054347735.1 → XP_054203710.1  short transient receptor potential channel 1 isoform X4

  4. XM_054347732.1 → XP_054203707.1  short transient receptor potential channel 1 isoform X1

  5. XM_054347733.1 → XP_054203708.1  short transient receptor potential channel 1 isoform X2

RNA

  1. XR_008486788.1 RNA Sequence

  2. XR_008486787.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48995.1 GenPept UniProtKB/Swiss-Prot:P48995

Gene LinkOut

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