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TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 [ Homo sapiens (human) ]

Gene ID: 7073, updated on 7-Apr-2024

Summary

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Official Symbol
TIAL1provided by HGNC
Official Full Name
TIA1 cytotoxic granule associated RNA binding protein like 1provided by HGNC
Primary source
HGNC:HGNC:11804
See related
Ensembl:ENSG00000151923 MIM:603413; AllianceGenome:HGNC:11804
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCBP; TIAR
Summary
The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 14.6), lymph node (RPKM 14.0) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
10q26.11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (119573465..119596964, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (120471044..120494540, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (121332977..121356476, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121150987-121151487 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:121160908-121162107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121164620-121165120 Neighboring gene microRNA 4681 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121203591-121204381 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121210069-121210568 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121211884-121212060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121214023-121214544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121225296-121225796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4120 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:121239005-121239584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121269325-121269826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121269827-121270326 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121274963-121275176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121275942-121276524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2874 Neighboring gene regulator of G protein signaling 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4125 Neighboring gene NANOG hESC enhancer GRCh37_chr10:121303486-121303994 Neighboring gene uncharacterized LOC105378512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121355707-121356705 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121356706-121357703 Neighboring gene Sharpr-MPRA regulatory region 3145 Neighboring gene MPRA-validated peak1112 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121396416-121396639 Neighboring gene RAD1 pseudogene 1 Neighboring gene ribosomal protein S8 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Distinct binding properties of TIAR RRMs and linker region. Kim HS, et al. RNA Biol, 2013 Apr. PMID 23603827, Free PMC Article
  2. Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR. Kim HS, et al. Mol Cell Biol, 2007 Oct. PMID 17682065, Free PMC Article
  3. Translational repression by RNA-binding protein TIAR. Mazan-Mamczarz K, et al. Mol Cell Biol, 2006 Apr. PMID 16537914, Free PMC Article
  4. Novel DNA-binding properties of the RNA-binding protein TIAR. Suswam EA, et al. Nucleic Acids Res, 2005. PMID 16091628, Free PMC Article
  5. TIA proteins are necessary but not sufficient for the tissue-specific splicing of the myosin phosphatase targeting subunit 1. Shukla S, et al. J Biol Chem, 2004 Apr 2. PMID 14736875

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation.
    Title: RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation.
  2. Depletion of TIAR accelerates mitotic entry and leads to chromosomal instability in response to replication stress, in a manner that can be alleviated by the concomitant depletion of Cdc25B or inhibition of CDK1. Since TIAR retains CDK1 in GMGs and attenuates CDK1 activity, we propose that the assembly of GMGs may represent a so far unrecognized mechanism that contributes to the activation of the G2/M checkpoint
    Title: TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress.
  3. The manipulation of miR2233p/TIAL1 interaction may be involved in the neuroprotective effects of DEX.
    Title: miR‑223‑3p/TIAL1 interaction is involved in the mechanisms associated with the neuroprotective effects of dexmedetomidine on hippocampal neuronal cells in vitro.
  4. Data indicate that both ELAVL1 and TIAR positively regulate endogenous SNCA in vivo.
    Title: Discovering the 3' UTR-mediated regulation of alpha-synuclein.
  5. we identified MT1JP as a critical factor in restraining cell transformation by modulating p53 translation through interactions with TIAR
    Title: LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway.
  6. Data suggest that TPD52 (tumor protein D52) and a TPD52 fragment (residues 78-280) along with TIA-1 (T-cell intracellular antigen-1) and TIAR (TIA-1-related protein) contribute to mRNA stability as cis-acting and trans-acting factors; 3prime-untranslated regions of TPD52, TPD53, and TPD54 regulate expression of their respective genes in a post-transcriptional manner by altering mRNA stability.
    Title: Tumor protein D52 expression is post-transcriptionally regulated by T-cell intercellular antigen (TIA) 1 and TIA-related protein via mRNA stability.
  7. results suggest that TIA-1 and TIAR are two new host factors that interact with 5-UTR of EV71 genome and positively regulate viral replication
    Title: TIA-1 and TIAR interact with 5'-UTR of enterovirus 71 genome and facilitate viral replication.
  8. TIAL1 inhibition of the exon 8 exclusion led to a decrease in SIRT1-Exon8 mRNA levels.
    Title: HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA.
  9. TIA proteins can function as long-term regulators of the ACTB mRNA metabolism in mouse and human cells.
    Title: Long-term reduction of T-cell intracellular antigens leads to increased beta-actin expression.
  10. A role for TIAR is identified in T-cells for control of translational specificity.
    Title: Genome-wide profiling reveals a role for T-cell intracellular antigens TIA1 and TIAR in the control of translational specificity in HeLa cells.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag co-localizes and interacts with G3BP1 and TIAR to modulate stress granule assembly during HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC33401

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables mRNA 3'-UTR AU-rich region binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-RNA adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response TAS
Traceable Author Statement
more info
 PubMed 
involved_in germ cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of miRNA-mediated gene silencing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of stem cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in stem cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in stem cell proliferation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytolytic granule IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in lysosome TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nucleolysin TIAR
Names
T-cluster binding protein
TIA-1-related nucleolysin
TIA1 related
aging-associated gene 7 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029240.1 RefSeqGene

    Range
    5066..28565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001033925.2 → NP_001029097.1  nucleolysin TIAR isoform 2

    See identical proteins and their annotated locations for NP_001029097.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a longer protein (isoform 2).
    Source sequence(s)
    AA972022, AC012468, AK125264, BC030025, M96954
    Consensus CDS
    CCDS31295.1
    UniProtKB/TrEMBL
    A8K5C4, Q2TSD2
    Related
    ENSP00000358089.2, ENST00000369093.6
    Conserved Domains (3) summary
    cd12620
    Location:222 → 294
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12616
    Location:10 → 107
    RRM1_TIAR; RNA recognition motif 1 (RRM1) found in nucleolysin TIAR and similar proteins
    cd12617
    Location:113 → 192
    RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins

  2. NM_001323964.2 → NP_001310893.1  nucleolysin TIAR isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform 3.
    Source sequence(s)
    AC012468, BC030025
    UniProtKB/TrEMBL
    Q49AS9
    Conserved Domains (2) summary
    cd12620
    Location:82 → 154
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:2 → 52
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_001323965.2 → NP_001310894.1  nucleolysin TIAR isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform 3.
    Source sequence(s)
    AC012468
    UniProtKB/TrEMBL
    Q49AS9
    Conserved Domains (2) summary
    cd12620
    Location:82 → 154
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:2 → 52
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. NM_001323967.2 → NP_001310896.1  nucleolysin TIAR isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform 3.
    Source sequence(s)
    AC012468
    UniProtKB/TrEMBL
    Q49AS9
    Conserved Domains (2) summary
    cd12620
    Location:82 → 154
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:2 → 52
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. NM_001323968.2 → NP_001310897.1  nucleolysin TIAR isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC012468
    UniProtKB/TrEMBL
    A8K5C4, Q2TSD2

  6. NM_001323969.2 → NP_001310898.1  nucleolysin TIAR isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC012468
    UniProtKB/TrEMBL
    A8K5C4, Q2TSD2
    Conserved Domains (3) summary
    cd12620
    Location:166 → 238
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12617
    Location:57 → 136
    RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:1 → 51
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. NM_001323970.2 → NP_001310899.1  nucleolysin TIAR isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC012468, BC128140
    UniProtKB/TrEMBL
    A8K5C4, Q2TSD2
    Conserved Domains (3) summary
    cd12620
    Location:183 → 255
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12617
    Location:74 → 153
    RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:19 → 68
    RRM_SF; RNA recognition motif (RRM) superfamily

  8. NM_003252.4 → NP_003243.1  nucleolysin TIAR isoform 1

    See identical proteins and their annotated locations for NP_003243.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AA972022, AC012468, AK125264, AL833106, BC030025
    Consensus CDS
    CCDS7613.1
    UniProtKB/Swiss-Prot
    A8K3T0, A8K4L9, Q01085
    UniProtKB/TrEMBL
    A8K5C4, Q2TSD2
    Related
    ENSP00000394902.2, ENST00000436547.7
    Conserved Domains (3) summary
    cd12620
    Location:205 → 277
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12616
    Location:10 → 90
    RRM1_TIAR; RNA recognition motif 1 (RRM1) found in nucleolysin TIAR and similar proteins
    cd12617
    Location:96 → 175
    RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins

RNA

  1. NR_136661.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC012468, AL833106

  2. NR_136662.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC012468

  3. NR_136663.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC012468, D64015

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    119573465..119596964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448151.2 → XP_024303919.1  nucleolysin TIAR isoform X1

    UniProtKB/TrEMBL
    A8K5C4, Q2TSD2
    Conserved Domains (3) summary
    cd12620
    Location:183 → 255
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12617
    Location:74 → 153
    RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:19 → 68
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_047425698.1 → XP_047281654.1  nucleolysin TIAR isoform X1

  3. XM_047425699.1 → XP_047281655.1  nucleolysin TIAR isoform X1

  4. XM_047425701.1 → XP_047281657.1  nucleolysin TIAR isoform X2

RNA

  1. XR_001747194.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    120471044..120494540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366667.1 → XP_054222642.1  nucleolysin TIAR isoform X1

  2. XM_054366665.1 → XP_054222640.1  nucleolysin TIAR isoform X1

  3. XM_054366666.1 → XP_054222641.1  nucleolysin TIAR isoform X1

  4. XM_054366669.1 → XP_054222644.1  nucleolysin TIAR isoform X2

  5. XM_054366668.1 → XP_054222643.1  nucleolysin TIAR isoform X2

RNA

  1. XR_008488259.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022333.1: Suppressed sequence

    Description
    NM_022333.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01085.1 GenPept UniProtKB/Swiss-Prot:Q01085

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