THBS1 thrombospondin 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: THBS1provided by HGNC
Official Full Name: thrombospondin 1provided by HGNC
Primary source: HGNC:HGNC:11785
See related: Ensembl:ENSG00000137801 MIM:188060; AllianceGenome:HGNC:11785
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TSP; THBS; TSP1; TSP-1; THBS-1
Summary: The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
Expression: Broad expression in appendix (RPKM 304.9), gall bladder (RPKM 219.5) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q14

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (39581079..39599466)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (37385886..37404273)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (39873280..39891667)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircTHBS1 promotes trophoblast cell migration and invasion and inhibits trophoblast apoptosis by regulating miR-136-3p/IGF2R axis.
Title: CircTHBS1 promotes trophoblast cell migration and invasion and inhibits trophoblast apoptosis by regulating miR-136-3p/IGF2R axis.
hsa_circ_0007919 promotes pancreatic cancer metastasis by modulating Sp1-mediated THBS1 transcription.
Title: hsa_circ_0007919 promotes pancreatic cancer metastasis by modulating Sp1-mediated THBS1 transcription.
THBS1[+] myeloid cells expand in SLD hepatocellular carcinoma and contribute to immunosuppression and unfavorable prognosis through TREM1.
Title: THBS1(+) myeloid cells expand in SLD hepatocellular carcinoma and contribute to immunosuppression and unfavorable prognosis through TREM1.
Thrombospondin-1 associated with carotid intima-media thickness among individuals with hypertension.
Title: Thrombospondin-1 associated with carotid intima-media thickness among individuals with hypertension.
THBS1 and THBS2 Enhance the In Vitro Proliferation, Adhesion, Migration and Invasion of Intrahepatic Cholangiocarcinoma Cells.
Title: THBS1 and THBS2 Enhance the In Vitro Proliferation, Adhesion, Migration and Invasion of Intrahepatic Cholangiocarcinoma Cells.
Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug-induced thromboembolism.
Title: Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug-induced thromboembolism.
Relationship between elevated circulating thrombospondin-1 levels and vascular complications in diabetes mellitus.
Title: Relationship between elevated circulating thrombospondin-1 levels and vascular complications in diabetes mellitus.
A-296G variant of THBS1 gene (rs1478605) is associated with a lower frequency of stroke in a Brazilian population with sickle cell anemia.
Title: A-296G variant of THBS1 gene (rs1478605) is associated with a lower frequency of stroke in a Brazilian population with sickle cell anemia.
Thrombospondin-1 promotes liver fibrosis by enhancing TGF-beta action in hepatic stellate cells.
Title: Thrombospondin-1 promotes liver fibrosis by enhancing TGF-β action in hepatic stellate cells.
LncRNA MIR217HG aggravates pressure-overload induced cardiac remodeling by activating miR-138/THBS1 pathway.
Title: LncRNA MIR217HG aggravates pressure-overload induced cardiac remodeling by activating miR-138/THBS1 pathway.

Submit: New GeneRIF Correction See all GeneRIFs (455)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	TSP1 inhibits HIV-1 infection of peripheral blood mononuclear cells and transformed T and promonocytic cell lines by its binding to HIV-1 gp120	PubMed
	env	Interaction of TSP1 with HIV-1 gp120 involves CSVTCG sequences in the type 1 properdin-like repeats of TSP1 and amino acids 281-300, 311-330, and 361-380 in the C2-V3-C3 domains of gp120	PubMed
Tat	tat	Thrombospondin-1 (TSP) prevents endothelial cell motility induced by HIV-1 Tat and inhibits angiogenic activity exerted by Tat in the Matrigel sponge model, suggesting downregulation of TSP may be permissive for development of KS-associated angiogenesis	PubMed
	tat	Thrombospondin-1 inhibits cell internalization and HIV-1 LTR transactivating activity of extracellular HIV-1 Tat, cell interaction and mitogenic activity of extracellular Tat, as well as the autocrine loop of stimulation exerted by endogenous Tat	PubMed
	tat	Thrombospondin-1 (TSP) binds to HIV-1 Tat, an interaction that can be inhibited by heparin which can bind to both TSP and Tat	PubMed
Vpr	vpr	HIV-1 Vpr potentiates the stimulation of thrombospondin 1 by glucocorticoids via the glucocorticoid receptor pathway	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15S1164 (e-PCR)
- UniSTS:66830

THBS1_279 (e-PCR)
- UniSTS:277811

RH77893 (e-PCR)
- UniSTS:70717

6STS01 (e-PCR)
- UniSTS:503906

PMC152639P1 (e-PCR)
- UniSTS:271234

RH70562 (e-PCR)
- UniSTS:22202

PMC165731P1 (e-PCR)
- UniSTS:271548

TCF12 (e-PCR)
- UniSTS:479952

THBS1 (e-PCR)
- UniSTS:266212

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	NAS Non-traceable Author Statement more info	PubMed
enables collagen V binding	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables extracellular matrix structural constituent	HDA more info	PubMed
enables extracellular matrix structural constituent	ISS Inferred from Sequence or Structural Similarity more info
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables fibrinogen binding	IDA Inferred from Direct Assay more info	PubMed
enables fibroblast growth factor binding	IDA Inferred from Direct Assay more info	PubMed
enables fibronectin binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables laminin binding	IDA Inferred from Direct Assay more info	PubMed
enables low-density lipoprotein particle binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables proteoglycan binding	TAS Traceable Author Statement more info	PubMed
enables transforming growth factor beta binding	ISS Inferred from Sequence or Structural Similarity more info
enables transforming growth factor beta binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in behavioral response to pain	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to heat	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in chronic inflammatory response	IEP Inferred from Expression Pattern more info	PubMed
involved_in engulfment of apoptotic cell	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	IEP Inferred from Expression Pattern more info	PubMed
involved_in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of blood vessel endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of dendritic cell antigen processing and presentation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of endothelial cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of fibrinolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of focal adhesion assembly	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of interleukin-12 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of long-chain fatty acid import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of nitric oxide mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of plasminogen activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_negative_effect nitric oxide-cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in peptide cross-linking	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood coagulation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of blood vessel endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fibroblast migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macrophage activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macrophage chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of reactive oxygen species metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transforming growth factor beta1 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to glucose	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	NAS Non-traceable Author Statement more info	PubMed
involved_in response to magnesium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to progesterone	TAS Traceable Author Statement more info	PubMed
involved_in response to testosterone	IEA Inferred from Electronic Annotation more info
involved_in response to unfolded protein	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with collagen-containing extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in collagen-containing extracellular matrix	TAS Traceable Author Statement more info	PubMed
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of fibrinogen complex	IDA Inferred from Direct Assay more info	PubMed
located_in platelet alpha granule	IDA Inferred from Direct Assay more info	PubMed
located_in platelet alpha granule lumen	TAS Traceable Author Statement more info
located_in sarcoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: thrombospondin-1

Names: glycoprotein G; thrombospondin-1p180; thrombospondin-p50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003246.4 → NP_003237.2 thrombospondin-1 precursor

See identical proteins and their annotated locations for NP_003237.2

Status: REVIEWED

Source sequence(s)

AC037198, AI147670, AI168683, AK304754, BC015134, BC136470, BG115371, BM512145, BM784452, BU676185, X14787

Consensus CDS

CCDS32194.1

UniProtKB/Swiss-Prot

A8K6H4, B4E3J7, B9EGH6, P07996, Q15667, Q59E99

Related

ENSP00000260356.5, ENST00000260356.6

Conserved Domains (10) summary

smart00209
Location:438 → 490

TSP1; Thrombospondin type 1 repeats

smart00210
Location:26 → 221

TSPN; Thrombospondin N-terminal -like domains

sd00001
Location:845 → 882

TSP3; TSP3 repeat_long [structural motif]

sd00002
Location:787 → 821

TSP3; TSP3 repeat_long [structural motif]

sd00003
Location:691 → 726

TSP3_1C; TSP3 repeat_1C [structural motif]

pfam00093
Location:318 → 372

VWC; von Willebrand factor type C domain

pfam02412
Location:846 → 882

TSP_3; Thrombospondin type 3 repeat

pfam00090
Location:383 → 428

TSP_1; Thrombospondin type 1 domain

pfam05735
Location:972 → 1169

TSP_C; Thrombospondin C-terminal region

pfam12947
Location:650 → 689

EGF_3; EGF domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000015.10 Reference GRCh38.p14 Primary Assembly

Range

39581079..39599466

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047432980.1 → XP_047288936.1 thrombospondin-1 isoform X1

UniProtKB/Swiss-Prot

A8K6H4, B4E3J7, B9EGH6, P07996, Q15667, Q59E99
XM_011521971.3 → XP_011520273.1 thrombospondin-1 isoform X2

Conserved Domains (10) summary

smart00209
Location:438 → 490

TSP1; Thrombospondin type 1 repeats

smart00210
Location:26 → 221

TSPN; Thrombospondin N-terminal -like domains

sd00001
Location:787 → 824

TSP3; TSP3 repeat_long [structural motif]

sd00002
Location:729 → 763

TSP3; TSP3 repeat_long [structural motif]

sd00003
Location:633 → 668

TSP3_1C; TSP3 repeat_1C [structural motif]

pfam00090
Location:383 → 428

TSP_1; Thrombospondin type 1 domain

pfam00093
Location:318 → 372

VWC; von Willebrand factor type C domain

pfam02412
Location:788 → 824

TSP_3; Thrombospondin type 3 repeat

pfam05735
Location:914 → 1111

TSP_C; Thrombospondin C-terminal region

pfam12947
Location:592 → 631

EGF_3; EGF domain