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TGFB1I1 transforming growth factor beta 1 induced transcript 1 [ Homo sapiens (human) ]

Gene ID: 7041, updated on 11-Apr-2024

Summary

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Official Symbol
TGFB1I1provided by HGNC
Official Full Name
transforming growth factor beta 1 induced transcript 1provided by HGNC
Primary source
HGNC:HGNC:11767
See related
Ensembl:ENSG00000140682 MIM:602353; AllianceGenome:HGNC:11767
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIC5; ARA55; HIC-5; TSC-5
Summary
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Expression
Broad expression in endometrium (RPKM 51.3), prostate (RPKM 29.5) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
16p11.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (31472152..31477960)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (31859540..31865348)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31483473..31489281)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31446802-31447302 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:31447884-31448054 Neighboring gene zinc finger protein 843 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31453737-31454532 Neighboring gene Sharpr-MPRA regulatory region 15326 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31464004-31464776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31464777-31465548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31468736-31469304 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:31469952-31470492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7419 Neighboring gene armadillo repeat containing 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31483812-31484352 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31486867-31487599 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31487600-31488331 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31488332-31489064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7421 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31500209-31500868 Neighboring gene solute carrier family 5 member 2 Neighboring gene RUS family member 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31518698-31519413 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31519414-31520128 Neighboring gene RUSF1 divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Exosome-mediated Hic-5 regulates proliferation and apoptosis of osteosarcoma via Wnt/β-catenin signal pathway. Sha L, et al. Aging (Albany NY), 2020 Dec 13. PMID 33310972, Free PMC Article
  2. TGFβ1I1 suppressed cell migration and invasion in colorectal cancer by inhibiting the TGF-β pathway and EMT progress. Ruan XJ, et al. Eur Rev Med Pharmacol Sci, 2020 Jul. PMID 32706067
  3. HIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression. Du X, et al. Cell Death Dis, 2019 Nov 18. PMID 31740661, Free PMC Article
  4. Hic-5 in pancreatic stellate cells affects proliferation, apoptosis, migration, invasion of pancreatic cancer cells and postoperative survival time of pancreatic cancer. Qian B, et al. Biomed Pharmacother, 2020 Jan. PMID 31683179
  5. Hic-5 expression is a major indicator of cancer cell morphology, migration, and plasticity in three-dimensional matrices. Gulvady AC, et al. Mol Biol Cell, 2018 Jul 15. PMID 29771639, Free PMC Article

See all (116) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TGFB1I1 promotes cell proliferation and migration in urothelial carcinoma.
    Title: TGFB1I1 promotes cell proliferation and migration in urothelial carcinoma.
  2. Paxillin family proteins Hic-5 and LPXN promote lipid storage by regulating the ubiquitination degradation of CIDEC.
    Title: Paxillin family proteins Hic-5 and LPXN promote lipid storage by regulating the ubiquitination degradation of CIDEC.
  3. Paxillin family of focal adhesion adaptor proteins and regulation of cancer cell invasion.
    Title: Paxillin family of focal adhesion adaptor proteins and regulation of cancer cell invasion.
  4. Exosome-mediated Hic-5 regulates proliferation and apoptosis of osteosarcoma via Wnt/beta-catenin signal pathway.
    Title: Exosome-mediated Hic-5 regulates proliferation and apoptosis of osteosarcoma via Wnt/β-catenin signal pathway.
  5. TGFbeta1I1 suppressed cell migration and invasion in colorectal cancer by inhibiting the TGF-beta pathway and EMT progress.
    Title: TGFβ1I1 suppressed cell migration and invasion in colorectal cancer by inhibiting the TGF-β pathway and EMT progress.
  6. Increased expression of the transforming growth factor beta-inducible gene HIC-5 in systemic sclerosis skin and fibroblasts: a novel antifibrotic therapeutic target.
    Title: Increased expression of the transforming growth factor β-inducible gene HIC-5 in systemic sclerosis skin and fibroblasts: a novel antifibrotic therapeutic target.
  7. HIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression.
    Title: HIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression.
  8. Results reveal novel regulation of vimentin organization/dynamics by the FA scaffold protein Hic-5 via modulation of RhoGTPases and downstream formin activity.
    Title: The focal adhesion scaffold protein Hic-5 regulates vimentin organization in fibroblasts.
  9. The molecular mechanism involved in Hic-5-mediated invasion.
    Title: Hic-5 in pancreatic stellate cells affects proliferation, apoptosis, migration, invasion of pancreatic cancer cells and postoperative survival time of pancreatic cancer.
  10. HIC-5 regulates mitochondrial ROS production in tumor cells while requiring activated KRAS to mediate its effect on NOX4 in oncogene-induced senescence and tumor invasiveness.
    Title: A mitochondrial ROS pathway controls matrix metalloproteinase 9 levels and invasive properties in RAS-activated cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (57)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables I-SMAD binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables Roundabout binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear androgen receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell fate commitment IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in morphogenesis of embryonic epithelium IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in focal adhesion HDA PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transforming growth factor beta-1-induced transcript 1 protein
Names
androgen receptor coactivator 55 kDa protein
androgen receptor coactivator ARA55
androgen receptor-associated protein of 55 kDa
hydrogen peroxide-inducible clone 5 protein
hydrogen peroxide-inducible clone-5

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042454.3 → NP_001035919.1  transforming growth factor beta-1-induced transcript 1 protein isoform 1

    See identical proteins and their annotated locations for NP_001035919.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC026471, AK313327
    Consensus CDS
    CCDS42156.1
    UniProtKB/Swiss-Prot
    B2R8D5, O43294, Q9BPW3, Q9Y2V5
    Related
    ENSP00000378332.3, ENST00000394863.8
    Conserved Domains (5) summary
    cd09337
    Location:287 → 338
    LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family
    cd09409
    Location:346 → 398
    LIM3_Paxillin; The third LIM domain of paxillin
    cd09412
    Location:405 → 456
    LIM4_Leupaxin; The fourth LIM domain of Leupaxin
    cd09336
    Location:228 → 280
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:86 → 106
    Paxillin; Paxillin family

  2. NM_001164719.1 → NP_001158191.1  transforming growth factor beta-1-induced transcript 1 protein isoform 2

    See identical proteins and their annotated locations for NP_001158191.1

    Status: REVIEWED

    Source sequence(s)
    AA992124, AC026471, BC017288
    Consensus CDS
    CCDS10713.1
    Related
    ENSP00000355117.3, ENST00000361773.7
    Conserved Domains (5) summary
    cd09337
    Location:270 → 321
    LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family
    cd09409
    Location:329 → 381
    LIM3_Paxillin; The third LIM domain of paxillin
    cd09412
    Location:388 → 439
    LIM4_Leupaxin; The fourth LIM domain of Leupaxin
    cd09336
    Location:211 → 263
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:69 → 89
    Paxillin; Paxillin family

  3. NM_015927.5 → NP_057011.2  transforming growth factor beta-1-induced transcript 1 protein isoform 2

    See identical proteins and their annotated locations for NP_057011.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC026471, BC001830
    Consensus CDS
    CCDS10713.1
    Related
    ENSP00000378327.2, ENST00000394858.6
    Conserved Domains (5) summary
    cd09337
    Location:270 → 321
    LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family
    cd09409
    Location:329 → 381
    LIM3_Paxillin; The third LIM domain of paxillin
    cd09412
    Location:388 → 439
    LIM4_Leupaxin; The fourth LIM domain of Leupaxin
    cd09336
    Location:211 → 263
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:69 → 89
    Paxillin; Paxillin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    31472152..31477960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450412.2 → XP_024306180.1  transforming growth factor beta-1-induced transcript 1 protein isoform X1

    Conserved Domains (5) summary
    cd09337
    Location:270 → 321
    LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family
    cd09409
    Location:329 → 381
    LIM3_Paxillin; The third LIM domain of paxillin
    cd09412
    Location:388 → 439
    LIM4_Leupaxin; The fourth LIM domain of Leupaxin
    cd09336
    Location:211 → 263
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:69 → 89
    Paxillin; Paxillin family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    31859540..31865348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313811.1 → XP_054169786.1  transforming growth factor beta-1-induced transcript 1 protein isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43294.2 GenPept UniProtKB/Swiss-Prot:O43294

Gene LinkOut

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