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TFDP2 transcription factor Dp-2 [ Homo sapiens (human) ]

Gene ID: 7029, updated on 5-Mar-2024

Summary

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Official Symbol
TFDP2provided by HGNC
Official Full Name
transcription factor Dp-2provided by HGNC
Primary source
HGNC:HGNC:11751
See related
Ensembl:ENSG00000114126 MIM:602160; AllianceGenome:HGNC:11751
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DP2
Summary
The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in ovary (RPKM 7.2), testis (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

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See TFDP2 in Genome Data Viewer
Location:
3q23
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (141944428..142149544, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (144691750..144896866, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (141663270..141868386, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:141623266-141623766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:141623767-141624267 Neighboring gene ATPase Na+/K+ transporting subunit beta 3 Neighboring gene RNA, U6 small nuclear 509, pseudogene Neighboring gene uncharacterized LOC124909442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:141656589-141657435 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:141719615-141719808 Neighboring gene Sharpr-MPRA regulatory region 4576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14783 Neighboring gene NANOG hESC enhancer GRCh37_chr3:141747218-141747719 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20640 Neighboring gene ribosomal protein L19 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14784 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:141868031-141868531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14787 Neighboring gene NANOG hESC enhancer GRCh37_chr3:141883131-141883866 Neighboring gene RNA, U6 small nuclear 425, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14788 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14789 Neighboring gene glycerol kinase 5 Neighboring gene NANOG hESC enhancer GRCh37_chr3:141961954-141962455 Neighboring gene Sharpr-MPRA regulatory region 12219 Neighboring gene 5'-3' exoribonuclease 1 Neighboring gene RNA, U6 small nuclear 1294, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. D prostanoid receptor 2 (chemoattractant receptor-homologous molecule expressed on TH2 cells) protein expression in asthmatic patients and its effects on bronchial epithelial cells. Stinson SE, et al. J Allergy Clin Immunol, 2015 Feb. PMID 25312757, Free PMC Article
  2. Inhibitory effects of novel E2F decoy oligodeoxynucleotides on mesangial cell proliferation by coexpression of E2F/DP. Park KK, et al. Biochem Biophys Res Commun, 2003 Sep 5. PMID 12927774
  3. Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. Zheng N, et al. Genes Dev, 1999 Mar 15. PMID 10090723, Free PMC Article
  4. Molecular cloning and expression pattern of the DP members of the chicken E2F transcription factor. Loiseau L, et al. Gene Expr, 1997. PMID 9368098, Free PMC Article
  5. Cloning and characterization of human DP2, a novel dimerization partner of E2F. Zhang Y, et al. Oncogene, 1995 Jun 1. PMID 7784053

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GAB2, GSPT1, TFDP2 and ZFPM1 are four new susceptibility loci for testicular germ cell tumor.
    Title: Identification of four new susceptibility loci for testicular germ cell tumour.
  2. DP2 is expressed by the bronchial epithelium, and its activation drives epithelial differentiation, suggesting that in addition to its well-characterized role in inflammatory cell migration, DP2 might contribute to airway remodeling in asthmatic patients.
    Title: D prostanoid receptor 2 (chemoattractant receptor-homologous molecule expressed on TH2 cells) protein expression in asthmatic patients and its effects on bronchial epithelial cells.
  3. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: New loci associated with kidney function and chronic kidney disease.
  4. This study demonstrates translation from an internal methionine.
    Title: DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
New loci associated with kidney function and chronic kidney disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of transcription factor Dp-2 (E2F dimerization partner 2; TFDP2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39131, DKFZp313O196

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in heart development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription factor Dp-2
Names
transcription factor Dp-2 (E2F dimerization partner 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001178138.2 → NP_001171609.1  transcription factor Dp-2 isoform 1

    See identical proteins and their annotated locations for NP_001171609.1

    Status: REVIEWED

    Source sequence(s)
    AC112504, BC013993, BC040991, DA321332
    Consensus CDS
    CCDS43159.1
    UniProtKB/Swiss-Prot
    Q14188
    Related
    ENSP00000418590.1, ENST00000467072.5
    Conserved Domains (3) summary
    cd14458
    Location:153 → 199
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:68 → 148
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:155 → 293
    DP; Transcription factor DP

  2. NM_001178139.2 → NP_001171610.1  transcription factor Dp-2 isoform 2

    See identical proteins and their annotated locations for NP_001171610.1

    Status: REVIEWED

    Source sequence(s)
    AC112504, AC128648, AC133435, AK314786, BC013993, BC040991, DA321332
    Consensus CDS
    CCDS54650.1
    UniProtKB/Swiss-Prot
    B7Z8C8, B7Z8L5, D3DNG1, E9PFC3, F8WAI2, Q13331, Q14187, Q14188, Q6R754, Q8WU88, Q9UG28
    Related
    ENSP00000420616.1, ENST00000489671.6
    Conserved Domains (3) summary
    cd14458
    Location:213 → 259
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:129 → 208
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:215 → 353
    DP; Transcription factor DP

  3. NM_001178140.2 → NP_001171611.1  transcription factor Dp-2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC112504, AC128648
    Consensus CDS
    CCDS54648.1
    UniProtKB/Swiss-Prot
    Q14188
    Related
    ENSP00000439782.2, ENST00000499676.5
    Conserved Domains (3) summary
    cd14458
    Location:185 → 231
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:100 → 180
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:187 → 325
    DP; Transcription factor DP

  4. NM_001178141.2 → NP_001171612.1  transcription factor Dp-2 isoform 4

    See identical proteins and their annotated locations for NP_001171612.1

    Status: REVIEWED

    Source sequence(s)
    AC112504, AK303634, BC040991, DC319314
    Consensus CDS
    CCDS54649.1
    UniProtKB/Swiss-Prot
    Q14188
    Related
    ENSP00000419036.1, ENST00000495310.5
    Conserved Domains (2) summary
    pfam02319
    Location:32 → 111
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:118 → 256
    DP; Transcription factor DP

  5. NM_001178142.2 → NP_001171613.1  transcription factor Dp-2 isoform 5

    See identical proteins and their annotated locations for NP_001171613.1

    Status: REVIEWED

    Source sequence(s)
    AC112504, AC128648, AK303181, BC040991
    Consensus CDS
    CCDS54647.1
    UniProtKB/Swiss-Prot
    Q14188
    Related
    ENSP00000418971.1, ENST00000477292.5
    Conserved Domains (3) summary
    cd14458
    Location:77 → 123
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:1 → 72
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:79 → 217
    DP; Transcription factor DP

  6. NM_001375756.1 → NP_001362685.1  transcription factor Dp-2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC112504, AC128648, AC133435
    Consensus CDS
    CCDS93401.1
    Related
    ENSP00000417585.1, ENST00000479040.5
    Conserved Domains (3) summary
    cd14458
    Location:152 → 198
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:68 → 147
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:154 → 292
    DP; Transcription factor DP

  7. NM_001375773.1 → NP_001362702.1  transcription factor Dp-2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC108679, AC112504, AC128648, AC133435
    Conserved Domains (3) summary
    cd14458
    Location:214 → 260
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:129 → 209
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:216 → 354
    DP; Transcription factor DP

  8. NM_001375774.1 → NP_001362703.1  transcription factor Dp-2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC112504, AC128648, AC133435
    Conserved Domains (3) summary
    cd14458
    Location:196 → 242
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:111 → 191
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:198 → 336
    DP; Transcription factor DP

  9. NM_001375775.1 → NP_001362704.1  transcription factor Dp-2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC108679, AC112504, AC128648, AC133435
    Conserved Domains (3) summary
    cd14458
    Location:191 → 237
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:107 → 186
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:193 → 331
    DP; Transcription factor DP

  10. NM_001375776.1 → NP_001362705.1  transcription factor Dp-2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC108679, AC112504, AC128648, AC133435
    Consensus CDS
    CCDS43159.1
    Conserved Domains (3) summary
    cd14458
    Location:153 → 199
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:68 → 148
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:155 → 293
    DP; Transcription factor DP

  11. NM_001375778.1 → NP_001362707.1  transcription factor Dp-2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC108679, AC112504, AC128648, AC133435
    Consensus CDS
    CCDS93401.1
    Conserved Domains (3) summary
    cd14458
    Location:152 → 198
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:68 → 147
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:154 → 292
    DP; Transcription factor DP

  12. NM_001375779.1 → NP_001362708.1  transcription factor Dp-2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC112504, AC128648, AC133435
    Conserved Domains (3) summary
    cd14458
    Location:100 → 146
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:16 → 95
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:102 → 240
    DP; Transcription factor DP

  13. NM_001375780.1 → NP_001362709.1  transcription factor Dp-2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC108679, AC112504, AC128648, AC133435
    Conserved Domains (3) summary
    cd14458
    Location:100 → 146
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:16 → 95
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:102 → 240
    DP; Transcription factor DP

  14. NM_006286.5 → NP_006277.1  transcription factor Dp-2 isoform 1

    See identical proteins and their annotated locations for NP_006277.1

    Status: REVIEWED

    Description
    Transcript Variant:).
    Source sequence(s)
    AC112504, BC040991, DC319314, U18422
    Consensus CDS
    CCDS43159.1
    UniProtKB/Swiss-Prot
    Q14188
    Related
    ENSP00000420599.1, ENST00000486111.5
    Conserved Domains (3) summary
    cd14458
    Location:153 → 199
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:68 → 148
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:155 → 293
    DP; Transcription factor DP

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    141944428..142149544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007100.3 → XP_016862589.1  transcription factor Dp-2 isoform X9

  2. XM_011513107.3 → XP_011511409.1  transcription factor Dp-2 isoform X8

    Conserved Domains (3) summary
    cd14458
    Location:214 → 260
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:129 → 209
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:216 → 352
    DP; Transcription factor DP

  3. XM_047448783.1 → XP_047304739.1  transcription factor Dp-2 isoform X9

  4. XM_017007091.2 → XP_016862580.1  transcription factor Dp-2 isoform X2

    UniProtKB/Swiss-Prot
    B7Z8C8, B7Z8L5, D3DNG1, E9PFC3, F8WAI2, Q13331, Q14187, Q14188, Q6R754, Q8WU88, Q9UG28
    Conserved Domains (3) summary
    cd14458
    Location:213 → 259
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:129 → 208
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:215 → 353
    DP; Transcription factor DP

  5. XM_047448775.1 → XP_047304731.1  transcription factor Dp-2 isoform X1

  6. XM_047448779.1 → XP_047304735.1  transcription factor Dp-2 isoform X4

  7. XM_047448785.1 → XP_047304741.1  transcription factor Dp-2 isoform X11

  8. XM_047448784.1 → XP_047304740.1  transcription factor Dp-2 isoform X10

  9. XM_047448782.1 → XP_047304738.1  transcription factor Dp-2 isoform X7

  10. XM_047448781.1 → XP_047304737.1  transcription factor Dp-2 isoform X6

  11. XM_047448780.1 → XP_047304736.1  transcription factor Dp-2 isoform X5

  12. XM_047448777.1 → XP_047304733.1  transcription factor Dp-2 isoform X4

  13. XM_047448776.1 → XP_047304732.1  transcription factor Dp-2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    144691750..144896866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347651.1 → XP_054203626.1  transcription factor Dp-2 isoform X2

    UniProtKB/Swiss-Prot
    B7Z8C8, B7Z8L5, D3DNG1, E9PFC3, F8WAI2, Q13331, Q14187, Q14188, Q6R754, Q8WU88, Q9UG28

  2. XM_054347656.1 → XP_054203631.1  transcription factor Dp-2 isoform X9

  3. XM_054347655.1 → XP_054203630.1  transcription factor Dp-2 isoform X8

  4. XM_054347657.1 → XP_054203632.1  transcription factor Dp-2 isoform X9

  5. XM_054347648.1 → XP_054203623.1  transcription factor Dp-2 isoform X1

  6. XM_054347649.1 → XP_054203624.1  transcription factor Dp-2 isoform X1

  7. XM_054347650.1 → XP_054203625.1  transcription factor Dp-2 isoform X2

    UniProtKB/Swiss-Prot
    B7Z8C8, B7Z8L5, D3DNG1, E9PFC3, F8WAI2, Q13331, Q14187, Q14188, Q6R754, Q8WU88, Q9UG28

  8. XM_054347653.1 → XP_054203628.1  transcription factor Dp-2 isoform X4

  9. XM_054347658.1 → XP_054203633.1  transcription factor Dp-2 isoform X10

  10. XM_054347654.1 → XP_054203629.1  transcription factor Dp-2 isoform X5

  11. XM_054347659.1 → XP_054203634.1  transcription factor Dp-2 isoform X11

  12. XM_054347652.1 → XP_054203627.1  transcription factor Dp-2 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14188.2 GenPept UniProtKB/Swiss-Prot:Q14188

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