TCF3 transcription factor 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TCF3provided by HGNC
Official Full Name: transcription factor 3provided by HGNC
Primary source: HGNC:HGNC:11633
See related: Ensembl:ENSG00000071564 MIM:147141; AllianceGenome:HGNC:11633
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: E2A; E47; p75; AGM8; ITF1; VDIR; AGM8A; AGM8B; TCF-3; bHLHb21
Summary: This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
Expression: Broad expression in testis (RPKM 16.2), lymph node (RPKM 12.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.3

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (1609292..1652615, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (1580117..1623781, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (1609291..1652614, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription factor 3 is dysregulated in megakaryocytes in myelofibrosis.
Title: Transcription factor 3 is dysregulated in megakaryocytes in myelofibrosis.
Rare TCF3 variants associated with pediatric B cell acute lymphoblastic leukemia.
Title: Rare TCF3 variants associated with pediatric B cell acute lymphoblastic leukemia.
Transcription Factor TCF3 Promotes Macrophage-Mediated Inflammation and MMP Secretion in Abdominal Aortic Aneurysm by Regulating miR-143-5p /CCL20.
Title: Transcription Factor TCF3 Promotes Macrophage-Mediated Inflammation and MMP Secretion in Abdominal Aortic Aneurysm by Regulating miR-143-5p /CCL20.
E47 as a novel glucocorticoid-dependent gene mediating lipid metabolism in patients with endogenous glucocorticoid excess.
Title: E47 as a novel glucocorticoid-dependent gene mediating lipid metabolism in patients with endogenous glucocorticoid excess.
TCF3 haploinsufficiency defined by immune, clinical, gene-dosage, and murine studies.
Title: TCF3 haploinsufficiency defined by immune, clinical, gene-dosage, and murine studies.
Molecular characterization of TCF3::PBX1 chromosomal breakpoints in acute lymphoblastic leukemia and their use for measurable residual disease assessment.
Title: Molecular characterization of TCF3::PBX1 chromosomal breakpoints in acute lymphoblastic leukemia and their use for measurable residual disease assessment.
Transcription factor 3 promotes migration and invasion potential and maintains cancer stemness by activating ID1 expression in esophageal squamous cell carcinoma.
Title: Transcription factor 3 promotes migration and invasion potential and maintains cancer stemness by activating ID1 expression in esophageal squamous cell carcinoma.
Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3.
Title: Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3.
Identification of TCF3 germline variants in pediatric B-cell acute lymphoblastic leukemia.
Title: Identification of TCF3 germline variants in pediatric B-cell acute lymphoblastic leukemia.
FBXL2 promotes E47 protein instability to inhibit breast cancer stemness and paclitaxel resistance.
Title: FBXL2 promotes E47 protein instability to inhibit breast cancer stemness and paclitaxel resistance.

Submit: New GeneRIF Correction See all GeneRIFs (135)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Agammaglobulinemia 8, autosomal dominant MedGen: C4310786 OMIM: 616941 GeneReviews: Not available	Compare labs
Agammaglobulinemia 8b, autosomal recessive MedGen: C5676958 OMIM: 619824 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G29322 (e-PCR)
- UniSTS:69389

RH12886 (e-PCR)
- UniSTS:63271

TCF3_4169 (e-PCR)
- UniSTS:462934

G15946 (e-PCR)
- UniSTS:33389

STS-M65214 (e-PCR)
- UniSTS:74964

WI-18183 (e-PCR)
- UniSTS:61171

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
contributes_to E-box binding	IDA Inferred from Direct Assay more info	PubMed
enables E-box binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to E-box binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables bHLH transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IC Inferred by Curator more info	PubMed
enables mitogen-activated protein kinase kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables vitamin D response element binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in B cell lineage commitment	NAS Non-traceable Author Statement more info	PubMed
involved_in immunoglobulin V(D)J recombination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immunoglobulin V(D)J recombination	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	ISA Inferred from Sequence Alignment more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription factor E2-alpha

Names: E2A-HLF fusion transcript protein; NOL1-TCF3 fusion; VDR interacting repressor; class B basic helix-loop-helix protein 21; helix-loop-helix protein HE47; immunoglobulin transcription factor 1; kappa-E2-binding factor; negative vitamin D response element-binding protein; transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); transcription factor ITF-1; vitamin D receptor-interacting repressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029953.2 RefSeqGene

Range

4932..48255

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1325

mRNA and Protein(s)

NM_001136139.4 → NP_001129611.1 transcription factor E2-alpha isoform E47

See identical proteins and their annotated locations for NP_001129611.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' UTR, lacks an exon and includes an alternate exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (E47, also known as Pan-1) is shorter than isoform E12. Variants 2 and 4 encode the same isoform (E47).

Source sequence(s)

AC005321, AC006274, AW028755, BG284440, BU528547, CD516687, CD674814, KC877695, M24404

Consensus CDS

CCDS45899.1

UniProtKB/TrEMBL

X6REB3

Related

ENSP00000468487.1, ENST00000588136.7

Conserved Domains (1) summary

cd18943
Location:538 → 611

bHLH_E-protein_E47-like; basic helix-loop-helix (bHLH) domain found in transcription factor E47 and similar proteins
NM_001351778.2 → NP_001338707.1 transcription factor E2-alpha isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, and contains an alternate splice structure in the 3' region, resulting in differences in the 3' UTR. The encoded isoform (3) has the same N- and C-termini, but is one aa shorter than isoform 1.

Source sequence(s)

AA251176, AC006274, AW968445, KC877695, M31222

UniProtKB/TrEMBL

Q6PJU3

Conserved Domains (2) summary

smart00353
Location:554 → 607

HLH; helix loop helix domain

pfam03985
Location:495 → 549

Paf1; Paf1
NM_001351779.2 → NP_001338708.1 transcription factor E2-alpha isoform E47

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an alternate penultimate exon compared to variant 1. The encoded isoform (E47, also known as Pan-1) is shorter than isoform E12. Variants 2 and 4 encode the same isoform (E47).

Source sequence(s)

AC005321, AC006274, AW028755, BG284440, KC877695, M24404, M31222

Consensus CDS

CCDS45899.1

UniProtKB/TrEMBL

X6REB3

Conserved Domains (1) summary

cd18943
Location:538 → 611

bHLH_E-protein_E47-like; basic helix-loop-helix (bHLH) domain found in transcription factor E47 and similar proteins
NM_003200.5 → NP_003191.1 transcription factor E2-alpha isoform E12

See identical proteins and their annotated locations for NP_003191.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (E12). This isoform is also known as Pan-2.

Source sequence(s)

AC005321, AC006274, KC877695, M31222

Consensus CDS

CCDS12074.1

UniProtKB/Swiss-Prot

P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9

UniProtKB/TrEMBL

Q6PJU3

Related

ENSP00000262965.5, ENST00000262965.12

Conserved Domains (2) summary

smart00353
Location:555 → 608

HLH; helix loop helix domain

pfam03985
Location:496 → 549

Paf1; Paf1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

1609292..1652615 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047439298.1 → XP_047295254.1 transcription factor E2-alpha isoform X12
XM_047439297.1 → XP_047295253.1 transcription factor E2-alpha isoform X10
XM_047439296.1 → XP_047295252.1 transcription factor E2-alpha isoform X11

Related

ENSP00000378813.3, ENST00000395423.7
XM_047439294.1 → XP_047295250.1 transcription factor E2-alpha isoform X11
XM_047439290.1 → XP_047295246.1 transcription factor E2-alpha isoform X9
XM_047439286.1 → XP_047295242.1 transcription factor E2-alpha isoform X8
XM_011528226.3 → XP_011526528.1 transcription factor E2-alpha isoform X8

UniProtKB/TrEMBL

X6REB3

Conserved Domains (1) summary

smart00353
Location:551 → 604

HLH; helix loop helix domain
XM_047439279.1 → XP_047295235.1 transcription factor E2-alpha isoform X5
XM_047439285.1 → XP_047295241.1 transcription factor E2-alpha isoform X7
XM_011528225.3 → XP_011526527.1 transcription factor E2-alpha isoform X7

UniProtKB/TrEMBL

X6REB3

Conserved Domains (1) summary

smart00353
Location:551 → 604

HLH; helix loop helix domain
XM_047439284.1 → XP_047295240.1 transcription factor E2-alpha isoform X6
XM_047439283.1 → XP_047295239.1 transcription factor E2-alpha isoform X6
XM_047439278.1 → XP_047295234.1 transcription factor E2-alpha isoform X4

UniProtKB/Swiss-Prot

P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
XM_047439277.1 → XP_047295233.1 transcription factor E2-alpha isoform X4

UniProtKB/Swiss-Prot

P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
XM_017027181.2 → XP_016882670.1 transcription factor E2-alpha isoform X4

UniProtKB/Swiss-Prot

P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9

UniProtKB/TrEMBL

Q6PJU3

Conserved Domains (2) summary

smart00353
Location:555 → 608

HLH; helix loop helix domain

pfam03985
Location:496 → 549

Paf1; Paf1
XM_047439261.1 → XP_047295217.1 transcription factor E2-alpha isoform X2
XM_017027178.2 → XP_016882667.1 transcription factor E2-alpha isoform X3

UniProtKB/TrEMBL

X6REB3

Conserved Domains (1) summary

smart00353
Location:581 → 634

HLH; helix loop helix domain
XM_047439262.1 → XP_047295218.1 transcription factor E2-alpha isoform X3

Related

ENSP00000396363.3, ENST00000453954.6
XM_006722855.5 → XP_006722918.1 transcription factor E2-alpha isoform X3

See identical proteins and their annotated locations for XP_006722918.1

UniProtKB/TrEMBL

X6REB3

Conserved Domains (1) summary

smart00353
Location:581 → 634

HLH; helix loop helix domain
XM_047439259.1 → XP_047295215.1 transcription factor E2-alpha isoform X1
XM_047439260.1 → XP_047295216.1 transcription factor E2-alpha isoform X1
XM_047439295.1 → XP_047295251.1 transcription factor E2-alpha isoform X11
XM_047439291.1 → XP_047295247.1 transcription factor E2-alpha isoform X9
XM_047439280.1 → XP_047295236.1 transcription factor E2-alpha isoform X5
XM_047439289.1 → XP_047295245.1 transcription factor E2-alpha isoform X7
XM_047439287.1 → XP_047295243.1 transcription factor E2-alpha isoform X7
XM_047439282.1 → XP_047295238.1 transcription factor E2-alpha isoform X6
XM_047439281.1 → XP_047295237.1 transcription factor E2-alpha isoform X6
XM_047439276.1 → XP_047295232.1 transcription factor E2-alpha isoform X4

UniProtKB/Swiss-Prot

P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
XM_047439258.1 → XP_047295214.1 transcription factor E2-alpha isoform X1
XM_047439293.1 → XP_047295249.1 transcription factor E2-alpha isoform X10
XM_047439292.1 → XP_047295248.1 transcription factor E2-alpha isoform X10
XM_047439275.1 → XP_047295231.1 transcription factor E2-alpha isoform X9
XM_047439274.1 → XP_047295230.1 transcription factor E2-alpha isoform X8
XM_047439273.1 → XP_047295229.1 transcription factor E2-alpha isoform X8
XM_047439271.1 → XP_047295227.1 transcription factor E2-alpha isoform X8
XM_047439267.1 → XP_047295223.1 transcription factor E2-alpha isoform X5
XM_047439266.1 → XP_047295222.1 transcription factor E2-alpha isoform X5
XM_047439288.1 → XP_047295244.1 transcription factor E2-alpha isoform X7
XM_047439272.1 → XP_047295228.1 transcription factor E2-alpha isoform X7
XM_047439270.1 → XP_047295226.1 transcription factor E2-alpha isoform X7
XM_047439269.1 → XP_047295225.1 transcription factor E2-alpha isoform X6
XM_047439268.1 → XP_047295224.1 transcription factor E2-alpha isoform X6
XM_047439265.1 → XP_047295221.1 transcription factor E2-alpha isoform X4

UniProtKB/Swiss-Prot

P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
XM_047439264.1 → XP_047295220.1 transcription factor E2-alpha isoform X4

UniProtKB/Swiss-Prot

P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
XM_047439263.1 → XP_047295219.1 transcription factor E2-alpha isoform X4

UniProtKB/Swiss-Prot

P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

1580117..1623781 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054321896.1 → XP_054177871.1 transcription factor E2-alpha isoform X12
XM_054321895.1 → XP_054177870.1 transcription factor E2-alpha isoform X10
XM_054321894.1 → XP_054177869.1 transcription factor E2-alpha isoform X11
XM_054321892.1 → XP_054177867.1 transcription factor E2-alpha isoform X11
XM_054321888.1 → XP_054177863.1 transcription factor E2-alpha isoform X9
XM_054321883.1 → XP_054177858.1 transcription factor E2-alpha isoform X8
XM_054321880.1 → XP_054177855.1 transcription factor E2-alpha isoform X8
XM_054321869.1 → XP_054177844.1 transcription factor E2-alpha isoform X5
XM_054321882.1 → XP_054177857.1 transcription factor E2-alpha isoform X7
XM_054321878.1 → XP_054177853.1 transcription factor E2-alpha isoform X7
XM_054321877.1 → XP_054177852.1 transcription factor E2-alpha isoform X6
XM_054321875.1 → XP_054177850.1 transcription factor E2-alpha isoform X6
XM_054321868.1 → XP_054177843.1 transcription factor E2-alpha isoform X4

UniProtKB/Swiss-Prot

P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
XM_054321866.1 → XP_054177841.1 transcription factor E2-alpha isoform X4

UniProtKB/Swiss-Prot

P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
XM_054321864.1 → XP_054177839.1 transcription factor E2-alpha isoform X4

UniProtKB/Swiss-Prot

P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
XM_054321854.1 → XP_054177829.1 transcription factor E2-alpha isoform X2
XM_054321856.1 → XP_054177831.1 transcription factor E2-alpha isoform X3
XM_054321857.1 → XP_054177832.1 transcription factor E2-alpha isoform X3
XM_054321855.1 → XP_054177830.1 transcription factor E2-alpha isoform X3
XM_054321852.1 → XP_054177827.1 transcription factor E2-alpha isoform X1
XM_054321853.1 → XP_054177828.1 transcription factor E2-alpha isoform X1
XM_054321893.1 → XP_054177868.1 transcription factor E2-alpha isoform X11
XM_054321889.1 → XP_054177864.1 transcription factor E2-alpha isoform X9
XM_054321871.1 → XP_054177846.1 transcription factor E2-alpha isoform X5
XM_054321887.1 → XP_054177862.1 transcription factor E2-alpha isoform X7
XM_054321885.1 → XP_054177860.1 transcription factor E2-alpha isoform X7
XM_054321873.1 → XP_054177848.1 transcription factor E2-alpha isoform X6
XM_054321872.1 → XP_054177847.1 transcription factor E2-alpha isoform X6
XM_054321862.1 → XP_054177837.1 transcription factor E2-alpha isoform X4

UniProtKB/Swiss-Prot

P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
XM_054321851.1 → XP_054177826.1 transcription factor E2-alpha isoform X1
XM_054321886.1 → XP_054177861.1 transcription factor E2-alpha isoform X7
XM_054321858.1 → XP_054177833.1 transcription factor E2-alpha isoform X5
XM_054321870.1 → XP_054177845.1 transcription factor E2-alpha isoform X5
XM_054321867.1 → XP_054177842.1 transcription factor E2-alpha isoform X4

UniProtKB/Swiss-Prot

P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
XM_054321865.1 → XP_054177840.1 transcription factor E2-alpha isoform X4

UniProtKB/Swiss-Prot

P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
XM_054321860.1 → XP_054177835.1 transcription factor E2-alpha isoform X8
XM_054321884.1 → XP_054177859.1 transcription factor E2-alpha isoform X8
XM_054321881.1 → XP_054177856.1 transcription factor E2-alpha isoform X7
XM_054321861.1 → XP_054177836.1 transcription factor E2-alpha isoform X9
XM_054321859.1 → XP_054177834.1 transcription factor E2-alpha isoform X8
XM_054321879.1 → XP_054177854.1 transcription factor E2-alpha isoform X7
XM_054321876.1 → XP_054177851.1 transcription factor E2-alpha isoform X6
XM_054321874.1 → XP_054177849.1 transcription factor E2-alpha isoform X6
XM_054321863.1 → XP_054177838.1 transcription factor E2-alpha isoform X4

UniProtKB/Swiss-Prot

P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
XM_054321891.1 → XP_054177866.1 transcription factor E2-alpha isoform X10
XM_054321890.1 → XP_054177865.1 transcription factor E2-alpha isoform X10