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MED22 mediator complex subunit 22 [ Homo sapiens (human) ]

Gene ID: 6837, updated on 11-Apr-2024

Summary

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Official Symbol
MED22provided by HGNC
Official Full Name
mediator complex subunit 22provided by HGNC
Primary source
HGNC:HGNC:11477
See related
Ensembl:ENSG00000148297 MIM:185641; AllianceGenome:HGNC:11477
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRB6; MED24; SURF5; surf-5
Summary
This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factors. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in ovary (RPKM 8.5), thyroid (RPKM 8.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
9q34.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (133338312..133348131, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (145552239..145562071, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (136205149..136214986, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene lipocalin 1 pseudogene 2 Neighboring gene surfeit 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:136202031-136203002 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:136203003-136203973 Neighboring gene ribosomal protein L21 pseudogene 81 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136208670-136209390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136212559-136213062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136213063-136213564 Neighboring gene Sharpr-MPRA regulatory region 11826 Neighboring gene ribosomal protein L7a Neighboring gene small nucleolar RNA, C/D box 24 Neighboring gene small nucleolar RNA, C/D box 36B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Tissue-specific processing of the Surf-5 and Surf-4 mRNAs. Garson K, et al. Gene Expr, 1996. PMID 9196076, Free PMC Article
  2. The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts. Angiolillo A, et al. Gene, 2002 Feb 6. PMID 11891058
  3. Inactivation of mediator complex protein 22 in podocytes results in intracellular vacuole formation, podocyte loss and premature death. Rodriguez PQ, et al. Sci Rep, 2020 Nov 18. PMID 33208756, Free PMC Article
  4. Mediator subunits MED1 and MED24 cooperatively contribute to pubertal mammary gland development and growth of breast carcinoma cells. Hasegawa N, et al. Mol Cell Biol, 2012 Apr. PMID 22331469, Free PMC Article
  5. The human Surfeit locus. Duhig T, et al. Genomics, 1998 Aug 15. PMID 9740673

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inactivation of mediator complex protein 22 in podocytes results in intracellular vacuole formation, podocyte loss and premature death.
    Title: Inactivation of mediator complex protein 22 in podocytes results in intracellular vacuole formation, podocyte loss and premature death.
  2. functional communications between the MED1 subunit and the MED24-containing submodule that mediate estrogen receptor functions and growth of both normal mammary epithelial cells and breast carcinoma cells.
    Title: Mediator subunits MED1 and MED24 cooperatively contribute to pubertal mammary gland development and growth of breast carcinoma cells.
  3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  5. Hu-Surf5 encodes three different transcripts, Surf-5a, Surf-5b, and Surf-5c, which result from alternative splicing.
    Title: The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts.
  6. This publication also contains human sequence.
    Title: Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: SURF6

Homology

Clone Names

  • MGC48682

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 22
Names
surfeit locus protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133640.5 → NP_598395.1  mediator of RNA polymerase II transcription subunit 22 isoform b

    See identical proteins and their annotated locations for NP_598395.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) represents the shorter transcript and encodes the longer isoform (b).
    Source sequence(s)
    AJ224359, AL772161, GD160955, HY154869
    Consensus CDS
    CCDS6963.1
    UniProtKB/Swiss-Prot
    B3KW83, B3KWX4, O76072, Q15528, Q5T8U0
    Related
    ENSP00000342343.5, ENST00000343730.10
    Conserved Domains (1) summary
    pfam06179
    Location:20 → 124
    Med22; Surfeit locus protein 5 subunit 22 of Mediator complex

  2. NM_181491.3 → NP_852468.1  mediator of RNA polymerase II transcription subunit 22 isoform c

    See identical proteins and their annotated locations for NP_852468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) differs in the 3' UTR and its transcription extends past a splice site used in variant b, resulting in a distinct 3' coding region. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform b.
    Source sequence(s)
    AL772161, BC024225, HY154869
    Consensus CDS
    CCDS6964.1
    UniProtKB/TrEMBL
    Q5T8T8
    Related
    ENSP00000478773.1, ENST00000610888.4
    Conserved Domains (1) summary
    pfam06179
    Location:20 → 124
    Med22; Surfeit locus protein 5 subunit 22 of Mediator complex

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    133338312..133348131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646201.1 Reference GRCh38.p14 PATCHES

    Range
    164406..174225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    145552239..145562071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_006752.4: Suppressed sequence

    Description
    NM_006752.4: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15528.2 GenPept UniProtKB/Swiss-Prot:Q15528

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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