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SSTR4 somatostatin receptor 4 [ Homo sapiens (human) ]

Gene ID: 6754, updated on 11-Apr-2024

Summary

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Official Symbol
SSTR4provided by HGNC
Official Full Name
somatostatin receptor 4provided by HGNC
Primary source
HGNC:HGNC:11333
See related
Ensembl:ENSG00000132671 MIM:182454; AllianceGenome:HGNC:11333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SS4R; SST4; SS4-R; SS-4-R
Summary
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

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See SSTR4 in Genome Data Viewer
Location:
20p11.21
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (23035312..23039237)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (23094793..23098718)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (23015949..23019874)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985449 Neighboring gene kinesin family member 15 pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:22946709-22947908 Neighboring gene uncharacterized LOC101929707 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:23016490-23017036 Neighboring gene Sharpr-MPRA regulatory region 8459 Neighboring gene thrombomodulin Neighboring gene uncharacterized LOC124904964

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. 111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors. Forssell-Aronsson EB, et al. J Nucl Med, 2000 Apr. PMID 10768564
  2. Somatostatin and its receptor family. Patel YC. Front Neuroendocrinol, 1999 Jul. PMID 10433861
  3. Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4. Xu Y, et al. Biochem Biophys Res Commun, 1993 Jun 15. PMID 8512564
  4. Cloning and characterization of a fourth human somatostatin receptor. Rohrer L, et al. Proc Natl Acad Sci U S A, 1993 May 1. PMID 8483934, Free PMC Article
  5. Human Somatostatin SST(4) Receptor Transgenic Mice: Construction and Brain Expression Pattern Characterization. Nemes B, et al. Int J Mol Sci, 2021 Apr 4. PMID 33916620, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human Somatostatin SST4 Receptor Transgenic Mice: Construction and Brain Expression Pattern Characterization.
    Title: Human Somatostatin SST(4) Receptor Transgenic Mice: Construction and Brain Expression Pattern Characterization.
  2. Characterization of Neurons Expressing the Novel Analgesic Drug Target Somatostatin Receptor 4 in Mouse and Human Brains.
    Title: Characterization of Neurons Expressing the Novel Analgesic Drug Target Somatostatin Receptor 4 in Mouse and Human Brains.
  3. Data showed that the distribution of somatostatin receptor (SSTR) subtypes among the 199 pancreatic neuroendocrine tumors (PNETs) was: SSTR2 (54.8%), SSTR1 (53.3%), SSTR4 (51.8%), SSTR5 (33.7%), and SSTR3 (28.6%).
    Title: Prognostic Value of Somatostatin Receptor Subtypes in Pancreatic Neuroendocrine Tumors.
  4. An immunohistochemical investigation of the expression of somatostatin receptor subtypes
    Title: An immunohistochemical investigation of the expression of somatostatin receptor subtypes - should therapeutic trials be performed to determine the efficacy of somatostatin analogs in treating advanced thyroid malignances?
  5. deregulated somatostatin signaling in the Alzheimer disease cortices studied cannot be explained by hypermethylation of the SST or SSTR4 promoter CpG islands.
    Title: Methylation analysis of SST and SSTR4 promoters in the neocortex of Alzheimer's disease patients.
  6. this study shows that CD26 is associated with SSTR4 in malignant pleural mesothelioma cells, and this interaction inhibits SSTR4-mediated cytostatic effects.
    Title: Regulation of somatostatin receptor 4-mediated cytostatic effects by CD26 in malignant pleural mesothelioma.
  7. High SSTR4 expression is associated with lymph node metastasis in gallbladder cancer.
    Title: Somatostatin receptors 3, 4 and 5 play important roles in gallbladder cancer.
  8. Data show that the mRNA levels of SSTR1, SSTR2, SSTR3, and SSTR5 were high in PET compared with AC, whereas the expression of SSTR4 was low in PET and AC.
    Title: Profiling of somatostatin receptor subtype expression by quantitative PCR and correlation with clinicopathological features in pancreatic endocrine tumors.
  9. Studies show that this study may be the basis for further functional studies to evaluate the role of somatostatin receptors sst1 to sst5 in the diabetic state.
    Title: Somatostatin receptor subtypes in human type 2 diabetic islets.
  10. Meta-analysis of gene-disease association. (HuGE Navigator)
    Title: Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables somatostatin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to glucocorticoid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in forebrain development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in somatostatin signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
somatostatin receptor type 4
Names
G-protein coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001052.4 → NP_001043.2  somatostatin receptor type 4

    See identical proteins and their annotated locations for NP_001043.2

    Status: VALIDATED

    Source sequence(s)
    AL049651
    Consensus CDS
    CCDS42856.1
    UniProtKB/Swiss-Prot
    P31391, Q17RM1, Q17RM3, Q9UIY1
    Related
    ENSP00000255008.3, ENST00000255008.5
    Conserved Domains (1) summary
    cd15973
    Location:48 → 322
    7tmA_SSTR4; somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    23035312..23039237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    23094793..23098718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31391.2 GenPept UniProtKB/Swiss-Prot:P31391

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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