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SSTR3 somatostatin receptor 3 [ Homo sapiens (human) ]

Gene ID: 6753, updated on 11-Apr-2024

Summary

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Official Symbol
SSTR3provided by HGNC
Official Full Name
somatostatin receptor 3provided by HGNC
Primary source
HGNC:HGNC:11332
See related
Ensembl:ENSG00000278195 MIM:182453; AllianceGenome:HGNC:11332
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SS3R; SST3; SS3-R; SS-3-R; SSR-28
Summary
This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Biased expression in testis (RPKM 3.5), brain (RPKM 1.1) and 8 other tissues See more
Orthologs
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Genomic context

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Location:
22q13.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (37204237..37220548, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (37664155..37680477, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (37600277..37608517, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18943 Neighboring gene interleukin 2 receptor subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18944 Neighboring gene IL2RB promoter Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18945 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18946 Neighboring gene IL2RB LTR promoter Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37575666-37576526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37576527-37577386 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37583391-37584026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37584027-37584660 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37584661-37585296 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr22:37585297-37585930 Neighboring gene C1q and TNF related 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37593748-37594318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37594319-37594888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18949 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37607356-37608335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18951 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18952 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13683 Neighboring gene ribosomal protein L39 pseudogene 41 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18953 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37629791-37630292 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37630293-37630792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37633073-37633751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37633752-37634430 Neighboring gene Rac family small GTPase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37638099-37638662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37638663-37639226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18957 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37641225-37641809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37649347-37649848 Neighboring gene uncharacterized LOC107985576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37656641-37657180

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of Phosphorylation Sites Regulating sst3 Somatostatin Receptor Trafficking. Lehmann A, et al. Mol Endocrinol, 2016 Jun. PMID 27101376, Free PMC Article
  2. Human somatostatin receptor-3 distinctively induces apoptosis in MCF-7 and cell cycle arrest in MDA-MB-231 breast cancer cells. War SA, et al. Mol Cell Endocrinol, 2015 Sep 15. PMID 26112183
  3. Influence of cigarette smoking on the level of mRNA of somatostatin receptor 3 (SSTR3) in the gastric mucosa of patients with functional dyspepsia. Stec-Michalska K, et al. Adv Med Sci, 2010. PMID 20570798
  4. Expression of somatostatin receptor subtype 3 in the gastric mucosa of dyspeptic patients in relation to Helicobacter pylori infection and a family history of gastric cancer. Stec-Michalska K, et al. J Gastroenterol Hepatol, 2008 Mar. PMID 17683502
  5. [Somatostatin receptor subtype 3 (SSTR3) mRNA level in gastric mucosa of patients with dyspepsia]. Stec-Michalska K, et al. Pol Merkur Lekarski, 2007 May. PMID 17679363

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.
    Title: HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.
  2. the C-terminal phosphorylation motif of the human sst3 receptor that regulates its agonist-promoted phosphorylation, beta-arrestin recruitment, and internalization of this clinically relevant receptor, is reported.
    Title: Identification of Phosphorylation Sites Regulating sst3 Somatostatin Receptor Trafficking.
  3. Data showed that the distribution of somatostatin receptor (SSTR) subtypes among the 199 pancreatic neuroendocrine tumors (PNETs) was: SSTR2 (54.8%), SSTR1 (53.3%), SSTR4 (51.8%), SSTR5 (33.7%), and SSTR3 (28.6%).
    Title: Prognostic Value of Somatostatin Receptor Subtypes in Pancreatic Neuroendocrine Tumors.
  4. Data indicate that somatostatin receptor scintigraphy (SRS) and immunohistochemical results for somatostatin and dopamine receptors sstr2, sstr3, sstr5 and D2R were compared in neuroendocrine neoplasms tissues.
    Title: Somatostatin and dopamine receptor expression in neuroendocrine neoplasms: correlation of immunohistochemical findings with somatostatin receptor scintigraphy visual scores.
  5. findings provide new insights in understanding the antiproliferative role of SSTR3 in breast tumor biology.
    Title: Human somatostatin receptor-3 distinctively induces apoptosis in MCF-7 and cell cycle arrest in MDA-MB-231 breast cancer cells.
  6. An immunohistochemical investigation of the expression of somatostatin receptor subtypes
    Title: An immunohistochemical investigation of the expression of somatostatin receptor subtypes - should therapeutic trials be performed to determine the efficacy of somatostatin analogs in treating advanced thyroid malignances?
  7. In conclusions, in CNFAs, high expression of somatostatin receptors is much less common than that of D2R
    Title: Dopamine 2 and somatostatin 1-5 receptors coexpression in clinically non-functioning pituitary adenomas.
  8. SSTR2A and SSTR3 are more likely to be expressed in SDH-deficient pheochromocytomas/paragangliomas compared with tumors demonstrating normal SDHB staining pattern.
    Title: Increased SSTR2A and SSTR3 expression in succinate dehydrogenase-deficient pheochromocytomas and paragangliomas.
  9. constitutive SSTR3 activity mediates transcriptional repression of GH.
    Title: Constitutive somatostatin receptor subtype-3 signaling suppresses growth hormone synthesis.
  10. High SSTR3 expression is associated with gallbladder cancer.
    Title: Somatostatin receptors 3, 4 and 5 play important roles in gallbladder cancer.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Joint influence of small-effect genetic variants on human longevity.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables somatostatin receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to glucocorticoid stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cerebellum development IEA
Inferred from Electronic Annotation
more info
  
involved_in forebrain development IEA
Inferred from Electronic Annotation
more info
  
involved_in hormone-mediated apoptotic signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to starvation IEA
Inferred from Electronic Annotation
more info
  
involved_in somatostatin signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in ciliary membrane TAS
Traceable Author Statement
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in non-motile cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
somatostatin receptor type 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001051.5 → NP_001042.1  somatostatin receptor type 3

    See identical proteins and their annotated locations for NP_001042.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK291165, BF514979, Z82188
    Consensus CDS
    CCDS13944.1
    UniProtKB/Swiss-Prot
    A8K550, P32745, Q53ZR7
    UniProtKB/TrEMBL
    Q86YF2
    Related
    ENSP00000480971.1, ENST00000610913.2
    Conserved Domains (2) summary
    pfam00001
    Location:61 → 313
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:55 → 158
    7tm_4; Olfactory receptor

  2. NM_001278687.2 → NP_001265616.1  somatostatin receptor type 3

    See identical proteins and their annotated locations for NP_001265616.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BF514979, BU584980, KF511460, Z82188
    Consensus CDS
    CCDS13944.1
    UniProtKB/Swiss-Prot
    A8K550, P32745, Q53ZR7
    UniProtKB/TrEMBL
    Q86YF2
    Related
    ENSP00000481325.1, ENST00000617123.1
    Conserved Domains (2) summary
    pfam00001
    Location:61 → 313
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:55 → 158
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    37204237..37220548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261721.5 → XP_005261778.1  somatostatin receptor type 3 isoform X1

    See identical proteins and their annotated locations for XP_005261778.1

    UniProtKB/Swiss-Prot
    A8K550, P32745, Q53ZR7
    UniProtKB/TrEMBL
    Q86YF2
    Conserved Domains (2) summary
    pfam00001
    Location:61 → 313
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:55 → 158
    7tm_4; Olfactory receptor

  2. XM_017028924.2 → XP_016884413.1  somatostatin receptor type 3 isoform X1

    UniProtKB/Swiss-Prot
    A8K550, P32745, Q53ZR7
    UniProtKB/TrEMBL
    Q86YF2
    Conserved Domains (2) summary
    pfam00001
    Location:61 → 313
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:55 → 158
    7tm_4; Olfactory receptor

  3. XM_047441473.1 → XP_047297429.1  somatostatin receptor type 3 isoform X1

    UniProtKB/Swiss-Prot
    A8K550, P32745, Q53ZR7

  4. XM_006724311.4 → XP_006724374.1  somatostatin receptor type 3 isoform X1

    See identical proteins and their annotated locations for XP_006724374.1

    UniProtKB/Swiss-Prot
    A8K550, P32745, Q53ZR7
    UniProtKB/TrEMBL
    Q86YF2
    Conserved Domains (2) summary
    pfam00001
    Location:61 → 313
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:55 → 158
    7tm_4; Olfactory receptor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    37664155..37680477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325877.1 → XP_054181852.1  somatostatin receptor type 3 isoform X1

    UniProtKB/Swiss-Prot
    A8K550, P32745, Q53ZR7

  2. XM_054325876.1 → XP_054181851.1  somatostatin receptor type 3 isoform X1

    UniProtKB/Swiss-Prot
    A8K550, P32745, Q53ZR7

  3. XM_054325875.1 → XP_054181850.1  somatostatin receptor type 3 isoform X1

    UniProtKB/Swiss-Prot
    A8K550, P32745, Q53ZR7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32745.1 GenPept UniProtKB/Swiss-Prot:P32745

Gene LinkOut

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