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SRP14 signal recognition particle 14 [ Homo sapiens (human) ]

Gene ID: 6727, updated on 5-Mar-2024

Summary

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Official Symbol
SRP14provided by HGNC
Official Full Name
signal recognition particle 14provided by HGNC
Primary source
HGNC:HGNC:11299
See related
Ensembl:ENSG00000140319 MIM:600708; AllianceGenome:HGNC:11299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALURBP
Summary
Enables RNA binding activity. Involved in protein targeting to ER. Located in nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 125.3), adrenal (RPKM 118.3) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
15q15.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (40035690..40039202, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (37841027..37844472, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40327891..40331403, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 4 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40251723-40252224 Neighboring gene H3 histone pseudogene 38 Neighboring gene Sharpr-MPRA regulatory region 10520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40314575-40315076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40315077-40315576 Neighboring gene uncharacterized LOC124903471 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:40330400-40331345 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:40331346-40332290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9222 Neighboring gene SRP14 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40347031-40347610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9226 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40354716-40355551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9228 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:40360521-40360704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9229 Neighboring gene uncharacterized LOC105370787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40369263-40369763

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SRP keeps polypeptides translocation-competent by slowing translation to match limiting ER-targeting sites. Lakkaraju AK, et al. Cell, 2008 May 2. PMID 18455985, Free PMC Article
  2. A human Alu RNA-binding protein whose expression is associated with accumulation of small cytoplasmic Alu RNA. Chang DY, et al. Mol Cell Biol, 1994 Jun. PMID 8196634, Free PMC Article
  3. The SRP9/14 subunit of the signal recognition particle (SRP) is present in more than 20-fold excess over SRP in primate cells and exists primarily free but also in complex with small cytoplasmic Alu RNAs. Bovia F, et al. Mol Biol Cell, 1995 Apr. PMID 7542942, Free PMC Article
  4. Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits. Ivanova E, et al. Nucleic Acids Res, 2015 Mar 11. PMID 25697503, Free PMC Article
  5. Residues in SRP9/14 essential for elongation arrest activity of the signal recognition particle define a positively charged functional domain on one side of the protein. Mary C, et al. RNA, 2010 May. PMID 20348448, Free PMC Article

See all (142) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dats show that Alu RNA promotes functional binding of Signal Recognition Particle proteins SRP9/14 to 40S ribosomal subunits.
    Title: Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits.
  2. mutational study on SRP9/14 that identified and characterized regions and single residues essential for elongation arrest activity
    Title: Residues in SRP9/14 essential for elongation arrest activity of the signal recognition particle define a positively charged functional domain on one side of the protein.
  3. SRP14 mutant proteins with absence of a peptide elongation delay caused inefficient targeting of preproteins leading to defects in secretion, depletion of proteins in the endogenous membranes, and reduced cell growth.
    Title: SRP keeps polypeptides translocation-competent by slowing translation to match limiting ER-targeting sites.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with signal recognition particle 14kDa (SRP14, homologous Alu RNA binding protein) is identified in a series of six affinity purification/mass spectrometry screens PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of signal recognition particle 14kDa (SRP14) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC14326

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 7S RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables endoplasmic reticulum signal peptide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to ER IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
signal recognition particle 14 kDa protein
Names
18 kDa Alu RNA-binding protein
homologous Alu RNA binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309434.1 → NP_001296363.1  signal recognition particle 14 kDa protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in its 5' coding region, which results in a frameshift and the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to variant 1.
    Source sequence(s)
    AC025168, BC051006, DA338824
    Conserved Domains (1) summary
    pfam02290
    Location:23 → 46
    SRP14; Signal recognition particle 14kD protein

  2. NM_003134.6 → NP_003125.3  signal recognition particle 14 kDa protein isoform 1

    See identical proteins and their annotated locations for NP_003125.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC035495, CV575824, DA338824
    Consensus CDS
    CCDS42017.1
    UniProtKB/Swiss-Prot
    B5BUF5, P37108, Q6B0K5, Q96Q14
    Related
    ENSP00000267884.6, ENST00000267884.11
    Conserved Domains (1) summary
    pfam02290
    Location:4 → 94
    SRP14; Signal recognition particle 14kD protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    40035690..40039202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    37841027..37844472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37108.2 GenPept UniProtKB/Swiss-Prot:P37108

Gene LinkOut

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