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SLPI secretory leukocyte peptidase inhibitor [ Homo sapiens (human) ]

Gene ID: 6590, updated on 5-Mar-2024

Summary

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Official Symbol
SLPIprovided by HGNC
Official Full Name
secretory leukocyte peptidase inhibitorprovided by HGNC
Primary source
HGNC:HGNC:11092
See related
Ensembl:ENSG00000124107 MIM:107285; AllianceGenome:HGNC:11092
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALP; MPI; ALK1; BLPI; HUSI; WAP4; WFDC4; HUSI-I
Summary
This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014]
Expression
Biased expression in salivary gland (RPKM 1077.5), lung (RPKM 390.4) and 4 other tissues See more
Orthologs
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Genomic context

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Location:
20q13.12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (45252239..45254564, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (46988133..46990454, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (43880880..43883205, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372630 Neighboring gene semenogelin 2 Neighboring gene uncharacterized LOC124904913 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12955 Neighboring gene matrilin 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12956 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17946 Neighboring gene tRNA-Val (anticodon CAC) 14-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High expression of secretory leukocyte protease inhibitor (SLPI) in stage III micro-satellite stable colorectal cancer is associated with reduced disease recurrence. Nugteren S, et al. Sci Rep, 2022 Jul 16. PMID 35842496, Free PMC Article
  2. Levels of secretory leukocyte protease inhibitor expression in acute wounds. Lai J, et al. J Wound Care, 2022 Jul 1. PMID 35797252
  3. Oral secretory leukocyte protease inhibitor (SLPI): Associations with oropharyngeal cancer and treatment outcome. Dickey BL, et al. PLoS One, 2021. PMID 34214131, Free PMC Article
  4. Significance of secretory leukocyte peptidase inhibitor in pleural fluid for the diagnosis of benign asbestos pleural effusion. Kishimoto T, et al. Sci Rep, 2021 Jun 21. PMID 34155270, Free PMC Article
  5. Expression of the immune modulator secretory leukocyte protease inhibitor (SLPI) in colorectal cancer liver metastases and matched primary tumors is associated with a poorer prognosis. Nugteren S, et al. Oncoimmunology, 2020 Oct 13. PMID 33101778, Free PMC Article

See all (164) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Secretory leukocyte protease inhibitor (SLPI) in cancer pathophysiology: Mechanisms of action and clinical implications.
    Title: Secretory leukocyte protease inhibitor (SLPI) in cancer pathophysiology: Mechanisms of action and clinical implications.
  2. Levels of mRNA and immunostaining of the antiproteases elafin and SLPI were enhanced strongly in inflamed versus noninflamed UC. Elafin and SLPI may be added to the list of defensin-like peptides with diminished induction in CD versus UC.
    Title: Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn's disease.
  3. SLPI regulation and activity is altered in the nasal mucosa of smokers.
    Title: Regulation and activity of secretory leukoprotease inhibitor (SLPI) is altered in smokers.
  4. High Expression of secretory leukocyte protease inhibitor is associated with metastasis in colorectal cancer.
    Title: Expression of secretory leukocyte protease inhibitor detected by immunohistochemistry correlating with prognosis and metastasis in colorectal cancer.
  5. High expression of secretory leukocyte protease inhibitor (SLPI) in stage III micro-satellite stable colorectal cancer is associated with reduced disease recurrence.
    Title: High expression of secretory leukocyte protease inhibitor (SLPI) in stage III micro-satellite stable colorectal cancer is associated with reduced disease recurrence.
  6. Levels of secretory leukocyte protease inhibitor expression in acute wounds.
    Title: Levels of secretory leukocyte protease inhibitor expression in acute wounds.
  7. Modulation of HIV Replication in Monocyte-Derived Macrophages (MDM) by Host Antiviral Factors Secretory Leukocyte Protease Inhibitor and Serpin Family C Member 1 Induced by Steroid Hormones.
    Title: Modulation of HIV Replication in Monocyte-Derived Macrophages (MDM) by Host Antiviral Factors Secretory Leukocyte Protease Inhibitor and Serpin Family C Member 1 Induced by Steroid Hormones.
  8. The interaction of smoking habit, SLPI and AnxA2 in HPV associated head and neck and other cancers.
    Title: The interaction of smoking habit, SLPI and AnxA2 in HPV associated head and neck and other cancers.
  9. Overexpression of secretory leukocyte peptidase inhibitor (SLPI) does not modulate experimental osteoarthritis but may be a biomarker for the disease.
    Title: Overexpression of secretory leukocyte peptidase inhibitor (SLPI) does not modulate experimental osteoarthritis but may be a biomarker for the disease.
  10. Oral secretory leukocyte protease inhibitor (SLPI): Associations with oropharyngeal cancer and treatment outcome.
    Title: Oral secretory leukocyte protease inhibitor (SLPI): Associations with oropharyngeal cancer and treatment outcome.
Submit: New GeneRIF Correction See all GeneRIFs (110)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The expression and production of secretory leukocyte protease inhibitor (SLPI), a 12-kDa mucosal antiviral protein, can be stimulated in oral epithelial cells through interactions with HIV-1 gp120 PubMed
retropepsin gag-pol Secretory levels of secretory leukocyte peptidase inhibitor (SLPI) from HIV-1 infected patients is enhanced in saliva PubMed
gag-pol Human secretory leukocyte protease inhibitor (hSLPI) inhibits HIV-1 infection of lymphocyte- and monocyte-derived tumor cell lines and peripheral blood lymphocytes PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antibacterial humoral response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in antibacterial humoral response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in modulation of process of another organism IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in specific granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
antileukoproteinase
Names
HUSI-1
WAP four-disulfide core domain protein 4
mucus proteinase inhibitor
protease inhibitor WAP4
secretory leukocyte protease inhibitor (antileukoproteinase)
seminal proteinase inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028137.1 RefSeqGene

    Range
    5002..7327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003064.4 → NP_003055.1  antileukoproteinase precursor

    See identical proteins and their annotated locations for NP_003055.1

    Status: REVIEWED

    Source sequence(s)
    BC020708
    Consensus CDS
    CCDS13347.1
    UniProtKB/Swiss-Prot
    B2R5H8, P03973, P07757
    Related
    ENSP00000342082.2, ENST00000338380.2
    Conserved Domains (2) summary
    smart00217
    Location:85 → 130
    WAP; Four-disulfide core domains
    pfam00095
    Location:31 → 73
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    45252239..45254564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    46988133..46990454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P03973.2 GenPept UniProtKB/Swiss-Prot:P03973

Gene LinkOut

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