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WNK3 WNK lysine deficient protein kinase 3 [ Homo sapiens (human) ]

Gene ID: 65267, updated on 5-Mar-2024

Summary

Official Symbol
WNK3provided by HGNC
Official Full Name
WNK lysine deficient protein kinase 3provided by HGNC
Primary source
HGNC:HGNC:14543
See related
Ensembl:ENSG00000196632 MIM:300358; AllianceGenome:HGNC:14543
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRS; MRXS2; PRKWNK3
Summary
This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Expression
Biased expression in testis (RPKM 7.2), brain (RPKM 1.1) and 5 other tissues See more
Orthologs
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Genomic context

See WNK3 in Genome Data Viewer
Location:
Xp11.22
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (54192823..54358900, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (53482708..53648791, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (54219256..54384479, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5322 Neighboring gene MPRA-validated peak7381 silencer Neighboring gene PHD finger protein 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29669 Neighboring gene Sharpr-MPRA regulatory region 9958 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:54091510-54091662 Neighboring gene family with sequence similarity 120 member C Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:54154862-54155382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20861 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20863 Neighboring gene ribosomal protein L37 pseudogene 24 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:54242133-54242784 Neighboring gene ribosomal protein L7a pseudogene 71 Neighboring gene MPRA-validated peak7382 silencer Neighboring gene RNA, U6 small nuclear 434, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:54415213-54415877 Neighboring gene MPRA-validated peak7383 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29670 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:54505803-54506356 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20864 Neighboring gene TSR2 ribosome maturation factor Neighboring gene FYVE, RhoGEF and PH domain containing 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:54556053-54556573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29673 Neighboring gene G protein nucleolar 3 like Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:54665616-54666141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29675

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ30437, FLJ42662, KIAA1566

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables molecular condensate scaffold activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cell volume homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of cell volume homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell volume homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in cellular hyperosmotic response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within maintenance of blood-brain barrier ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in monoatomic ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of pancreatic juice secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in non-membrane-bounded organelle assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of osmosensory signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of sodium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of sodium ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of calcium ion import IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of regulation of monoatomic cation transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of regulation of monoatomic cation transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in adherens junction ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in bicellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase WNK3
Names
Prieto X-linked mental retardation syndrome
protein kinase with no lysine 3
NP_001002838.1
NP_001382095.1
NP_065973.2
XP_011529104.1
XP_016885230.1
XP_016885231.1
XP_016885232.1
XP_016885233.1
XP_016885234.1
XP_047298332.1
XP_047298333.1
XP_047298334.1
XP_047298335.1
XP_047298336.1
XP_047298337.1
XP_047298338.1
XP_047298339.1
XP_047298340.1
XP_047298341.1
XP_047298342.1
XP_047298343.1
XP_047298344.1
XP_054183574.1
XP_054183575.1
XP_054183576.1
XP_054183577.1
XP_054183578.1
XP_054183579.1
XP_054183580.1
XP_054183581.1
XP_054183582.1
XP_054183583.1
XP_054183584.1
XP_054183585.1
XP_054183586.1
XP_054183587.1
XP_054183588.1
XP_054183589.1
XP_054183590.1
XP_054183591.1
XP_054183592.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021259.2 RefSeqGene

    Range
    5001..170183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001002838.4NP_001002838.1  serine/threonine-protein kinase WNK3 isoform 2

    See identical proteins and their annotated locations for NP_001002838.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AJ409088, AL591766, AY352048, R44257, Z84469
    Consensus CDS
    CCDS35302.1
    UniProtKB/Swiss-Prot
    Q9BYP7
    Related
    ENSP00000364312.3, ENST00000375169.7
    Conserved Domains (2) summary
    cd14031
    Location:136410
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:426489
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
  2. NM_001395166.1NP_001382095.1  serine/threonine-protein kinase WNK3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL049793, AL591766, Z84469
    Consensus CDS
    CCDS35302.1
    Conserved Domains (2) summary
    cd14031
    Location:136410
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:426489
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
  3. NM_020922.5NP_065973.2  serine/threonine-protein kinase WNK3 isoform 1

    See identical proteins and their annotated locations for NP_065973.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL591766, AY352048, R44257, Z84469
    Consensus CDS
    CCDS14357.1
    UniProtKB/Swiss-Prot
    B1AKG2, Q5JRC1, Q6JP76, Q8TCX6, Q9BYP7, Q9HCK6
    Related
    ENSP00000346667.2, ENST00000354646.7
    Conserved Domains (3) summary
    smart00220
    Location:152405
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14031
    Location:136410
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:426463
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    54192823..54358900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442382.1XP_047298338.1  serine/threonine-protein kinase WNK3 isoform X4

  2. XM_047442379.1XP_047298335.1  serine/threonine-protein kinase WNK3 isoform X3

  3. XM_017029744.2XP_016885233.1  serine/threonine-protein kinase WNK3 isoform X1

    UniProtKB/Swiss-Prot
    B1AKG2, Q5JRC1, Q6JP76, Q8TCX6, Q9BYP7, Q9HCK6
    Conserved Domains (3) summary
    smart00220
    Location:152405
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14031
    Location:136410
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:426463
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  4. XM_047442383.1XP_047298339.1  serine/threonine-protein kinase WNK3 isoform X4

  5. XM_047442381.1XP_047298337.1  serine/threonine-protein kinase WNK3 isoform X4

  6. XM_047442378.1XP_047298334.1  serine/threonine-protein kinase WNK3 isoform X3

  7. XM_017029743.2XP_016885232.1  serine/threonine-protein kinase WNK3 isoform X1

    UniProtKB/Swiss-Prot
    B1AKG2, Q5JRC1, Q6JP76, Q8TCX6, Q9BYP7, Q9HCK6
    Conserved Domains (3) summary
    smart00220
    Location:152405
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14031
    Location:136410
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:426463
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  8. XM_011530802.3XP_011529104.1  serine/threonine-protein kinase WNK3 isoform X3

    See identical proteins and their annotated locations for XP_011529104.1

    UniProtKB/Swiss-Prot
    Q9BYP7
    Conserved Domains (3) summary
    smart00220
    Location:152405
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14031
    Location:136410
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:426463
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  9. XM_017029745.2XP_016885234.1  serine/threonine-protein kinase WNK3 isoform X2

    UniProtKB/Swiss-Prot
    Q9BYP7
  10. XM_017029741.2XP_016885230.1  serine/threonine-protein kinase WNK3 isoform X1

    UniProtKB/Swiss-Prot
    B1AKG2, Q5JRC1, Q6JP76, Q8TCX6, Q9BYP7, Q9HCK6
    Conserved Domains (3) summary
    smart00220
    Location:152405
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14031
    Location:136410
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:426463
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  11. XM_047442380.1XP_047298336.1  serine/threonine-protein kinase WNK3 isoform X4

  12. XM_047442376.1XP_047298332.1  serine/threonine-protein kinase WNK3 isoform X3

  13. XM_017029742.2XP_016885231.1  serine/threonine-protein kinase WNK3 isoform X1

    UniProtKB/Swiss-Prot
    B1AKG2, Q5JRC1, Q6JP76, Q8TCX6, Q9BYP7, Q9HCK6
    Conserved Domains (3) summary
    smart00220
    Location:152405
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14031
    Location:136410
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:426463
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  14. XM_047442377.1XP_047298333.1  serine/threonine-protein kinase WNK3 isoform X3

  15. XM_047442388.1XP_047298344.1  serine/threonine-protein kinase WNK3 isoform X5

  16. XM_047442387.1XP_047298343.1  serine/threonine-protein kinase WNK3 isoform X5

  17. XM_047442384.1XP_047298340.1  serine/threonine-protein kinase WNK3 isoform X5

  18. XM_047442385.1XP_047298341.1  serine/threonine-protein kinase WNK3 isoform X5

  19. XM_047442386.1XP_047298342.1  serine/threonine-protein kinase WNK3 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    53482708..53648791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327611.1XP_054183586.1  serine/threonine-protein kinase WNK3 isoform X4

  2. XM_054327608.1XP_054183583.1  serine/threonine-protein kinase WNK3 isoform X3

  3. XM_054327602.1XP_054183577.1  serine/threonine-protein kinase WNK3 isoform X1

    UniProtKB/Swiss-Prot
    B1AKG2, Q5JRC1, Q6JP76, Q8TCX6, Q9BYP7, Q9HCK6
  4. XM_054327612.1XP_054183587.1  serine/threonine-protein kinase WNK3 isoform X4

  5. XM_054327610.1XP_054183585.1  serine/threonine-protein kinase WNK3 isoform X4

  6. XM_054327607.1XP_054183582.1  serine/threonine-protein kinase WNK3 isoform X3

  7. XM_054327601.1XP_054183576.1  serine/threonine-protein kinase WNK3 isoform X1

    UniProtKB/Swiss-Prot
    B1AKG2, Q5JRC1, Q6JP76, Q8TCX6, Q9BYP7, Q9HCK6
  8. XM_054327609.1XP_054183584.1  serine/threonine-protein kinase WNK3 isoform X4

  9. XM_054327605.1XP_054183580.1  serine/threonine-protein kinase WNK3 isoform X3

  10. XM_054327600.1XP_054183575.1  serine/threonine-protein kinase WNK3 isoform X1

    UniProtKB/Swiss-Prot
    B1AKG2, Q5JRC1, Q6JP76, Q8TCX6, Q9BYP7, Q9HCK6
  11. XM_054327604.1XP_054183579.1  serine/threonine-protein kinase WNK3 isoform X3

  12. XM_054327603.1XP_054183578.1  serine/threonine-protein kinase WNK3 isoform X2

  13. XM_054327599.1XP_054183574.1  serine/threonine-protein kinase WNK3 isoform X1

    UniProtKB/Swiss-Prot
    B1AKG2, Q5JRC1, Q6JP76, Q8TCX6, Q9BYP7, Q9HCK6
  14. XM_054327606.1XP_054183581.1  serine/threonine-protein kinase WNK3 isoform X3

  15. XM_054327617.1XP_054183592.1  serine/threonine-protein kinase WNK3 isoform X5

  16. XM_054327616.1XP_054183591.1  serine/threonine-protein kinase WNK3 isoform X5

  17. XM_054327614.1XP_054183589.1  serine/threonine-protein kinase WNK3 isoform X5

  18. XM_054327613.1XP_054183588.1  serine/threonine-protein kinase WNK3 isoform X5

  19. XM_054327615.1XP_054183590.1  serine/threonine-protein kinase WNK3 isoform X5