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CDCP1 CUB domain containing protein 1 [ Homo sapiens (human) ]

Gene ID: 64866, updated on 3-Apr-2024

Summary

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Official Symbol
CDCP1provided by HGNC
Official Full Name
CUB domain containing protein 1provided by HGNC
Primary source
HGNC:HGNC:24357
See related
Ensembl:ENSG00000163814 MIM:611735; AllianceGenome:HGNC:24357
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD318; TRASK; SIMA135
Summary
This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Expression
Broad expression in esophagus (RPKM 12.2), skin (RPKM 11.1) and 15 other tissues See more
Orthologs
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Genomic context

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Location:
3p21.31
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (45082277..45146482, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (45098021..45162916, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (45123769..45187870, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene exosome component 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:45068175-45068676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:45068677-45069176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:45075939-45076588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:45076589-45077236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14277 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14278 Neighboring gene C-type lectin domain family 3 member B Neighboring gene RNA, U5B small nuclear 3, pseudogene Neighboring gene uncharacterized LOC124906233 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:45165469-45165970 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:45165971-45166470 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:45169788-45170032 Neighboring gene Sharpr-MPRA regulatory region 12576 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:45207705-45208668 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:45208669-45209632 Neighboring gene ribosomal protein S24 pseudogene 8 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:45240939-45242138 Neighboring gene uncharacterized LOC101928636 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:45256576-45257076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:45257077-45257577

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Metastatic prostate cancer-derived extracellular vesicles facilitate osteoclastogenesis by transferring the CDCP1 protein. Urabe F, et al. J Extracell Vesicles, 2023 Mar. PMID 36880252, Free PMC Article
  2. CDCP1 (CUB domain containing protein 1) is a potential urine-based biomarker in the diagnosis of low-grade urothelial carcinoma. Liu CL, et al. PLoS One, 2023. PMID 36862682, Free PMC Article
  3. CDCP1: A promising diagnostic biomarker and therapeutic target for human cancer. Qi X, et al. Life Sci, 2022 Jul 15. PMID 35504333
  4. Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers. Lim SA, et al. J Clin Invest, 2022 Feb 15. PMID 35166238, Free PMC Article
  5. Evaluation of CDCP1 (CD318) and endoglin (CD105) expression as prognostic markers in acute myeloid leukemia. Ebian HF, et al. Cancer Biomark, 2022. PMID 34958004

See all (114) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of CDCP1 and Cardiac Fibrosis.
    Title: Myocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of CDCP1 and Cardiac Fibrosis.
  2. Metastatic prostate cancer-derived extracellular vesicles facilitate osteoclastogenesis by transferring the CDCP1 protein.
    Title: Metastatic prostate cancer-derived extracellular vesicles facilitate osteoclastogenesis by transferring the CDCP1 protein.
  3. CDCP1 (CUB domain containing protein 1) is a potential urine-based biomarker in the diagnosis of low-grade urothelial carcinoma.
    Title: CDCP1 (CUB domain containing protein 1) is a potential urine-based biomarker in the diagnosis of low-grade urothelial carcinoma.
  4. CDCP1 expression is frequently increased in aggressive urothelial carcinoma and promotes urothelial tumor progression.
    Title: CDCP1 expression is frequently increased in aggressive urothelial carcinoma and promotes urothelial tumor progression.
  5. Evaluation of CDCP1 (CD318) and endoglin (CD105) expression as prognostic markers in acute myeloid leukemia.
    Title: Evaluation of CDCP1 (CD318) and endoglin (CD105) expression as prognostic markers in acute myeloid leukemia.
  6. CDCP1: A promising diagnostic biomarker and therapeutic target for human cancer.
    Title: CDCP1: A promising diagnostic biomarker and therapeutic target for human cancer.
  7. SRC kinase activator CDCP1 promotes hepatocyte growth factor-induced cell migration/invasion of a subset of breast cancer cells.
    Title: SRC kinase activator CDCP1 promotes hepatocyte growth factor-induced cell migration/invasion of a subset of breast cancer cells.
  8. Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.
    Title: Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.
  9. Preclinical Molecular PET-CT Imaging Targeting CDCP1 in Colorectal Cancer.
    Title: Preclinical Molecular PET-CT Imaging Targeting CDCP1 in Colorectal Cancer.
  10. Prospective Identification of Elevated Circulating CDCP1 in Patients Years before Onset of Lung Cancer.
    Title: Prospective Identification of Elevated Circulating CDCP1 in Patients Years before Onset of Lung Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (85)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CUB domain-containing protein 1
Names
membrane glycoprotein gp140
subtractive immunization M plus HEp3-associated 135 kDa protein
transmembrane and associated with src kinases

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022842.5 → NP_073753.3  CUB domain-containing protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_073753.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AY026461, AY167484
    Consensus CDS
    CCDS2727.1
    UniProtKB/Swiss-Prot
    Q49UB4, Q6NT71, Q6U9Y2, Q8WU91, Q96QU7, Q9H5V8, Q9H676, Q9H8C2
    Related
    ENSP00000296129.1, ENST00000296129.6
    Conserved Domains (1) summary
    cl00049
    Location:225 → 297
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

  2. NM_178181.3 → NP_835488.1  CUB domain-containing protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_835488.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) transcribes past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AY358779, BC021099
    Consensus CDS
    CCDS46812.1
    UniProtKB/Swiss-Prot
    Q9H5V8
    Related
    ENSP00000399342.2, ENST00000425231.2
    Conserved Domains (1) summary
    cl00049
    Location:225 → 297
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    45082277..45146482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453718.2 → XP_024309486.1  CUB domain-containing protein 1 isoform X3

    Conserved Domains (1) summary
    cl00049
    Location:159 → 231
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

  2. XM_011534024.2 → XP_011532326.1  CUB domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    cl00049
    Location:224 → 296
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

  3. XM_017007070.2 → XP_016862559.1  CUB domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0Y0BS51, A0A172Q398

  4. XM_047448759.1 → XP_047304715.1  CUB domain-containing protein 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    45098021..45162916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347604.1 → XP_054203579.1  CUB domain-containing protein 1 isoform X3

  2. XM_054347602.1 → XP_054203577.1  CUB domain-containing protein 1 isoform X1

  3. XM_054347603.1 → XP_054203578.1  CUB domain-containing protein 1 isoform X2

  4. XM_054347605.1 → XP_054203580.1  CUB domain-containing protein 1 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H5V8.3 GenPept UniProtKB/Swiss-Prot:Q9H5V8

Gene LinkOut

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