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GPR135 G protein-coupled receptor 135 [ Homo sapiens (human) ]

Gene ID: 64582, updated on 5-Mar-2024

Summary

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Official Symbol
GPR135provided by HGNC
Official Full Name
G protein-coupled receptor 135provided by HGNC
Primary source
HGNC:HGNC:19991
See related
Ensembl:ENSG00000181619 MIM:607970; AllianceGenome:HGNC:19991
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HUMNPIIY20
Summary
Enables arrestin family protein binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in endosome and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 3.7), ovary (RPKM 1.1) and 20 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
14q23.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (59452783..59465380, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (53659699..53672299, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (59927477..59932098, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8456 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5803 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:59655908-59656667 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8458 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_34577 Neighboring gene peptidylprolyl isomerase A pseudogene 5 Neighboring gene Sharpr-MPRA regulatory region 14842 Neighboring gene dishevelled associated activator of morphogenesis 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5805 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:59797736-59798544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8459 Neighboring gene NANOG hESC enhancer GRCh37_chr14:59862330-59862839 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_34615 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8461 Neighboring gene uncharacterized LOC124903326 Neighboring gene trans-L-3-hydroxyproline dehydratase Neighboring gene JNK1/MAPK8 associated membrane protein Neighboring gene coiled-coil domain containing 175

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Asbestos-associated genome-wide DNA methylation changes in lung cancer. Kettunen E, et al. Int J Cancer, 2017 Nov 15. PMID 28722770
  2. Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT(2) receptor reciprocally modulate their signaling functions. Oishi A, et al. Sci Rep, 2017 Aug 21. PMID 28827538, Free PMC Article
  3. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. Fredriksson R, et al. FEBS Lett, 2003 Nov 20. PMID 14623098
  4. The global gene-expression profiles of U-937 human macrophages treated with Tat peptide and Tat-FITC conjugate. Lin CW, et al. J Drug Target, 2012 Jul. PMID 22632162
  5. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Collectively, these data show that GPR61, GPR62 and GPR135 are unable to bind melatonin, but show a reciprocal regulatory interaction with MT2 receptors.
    Title: Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT(2) receptor reciprocally modulate their signaling functions.
  2. GPR135 hypermethylation is associated with lung cancer.
    Title: Asbestos-associated genome-wide DNA methylation changes in lung cancer.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides downregulate gene expression of G protein-coupled receptor 135 (GPR135) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arrestin family protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
G-protein coupled receptor 135
Names
probable G-protein coupled receptor 135

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022571.6 → NP_072093.2  G-protein coupled receptor 135

    See identical proteins and their annotated locations for NP_072093.2

    Status: VALIDATED

    Source sequence(s)
    AL159140, AY288418, BC032831, BX094623
    Consensus CDS
    CCDS9738.1
    UniProtKB/Swiss-Prot
    Q7Z604, Q86SM3, Q8IZ08, Q8NH39
    Related
    ENSP00000378548.1, ENST00000395116.2
    Conserved Domains (2) summary
    cd14964
    Location:139 → 161
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:120 → 398
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    59452783..59465380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021599.3 → XP_016877088.1  G-protein coupled receptor 135 isoform X1

    UniProtKB/Swiss-Prot
    Q7Z604, Q86SM3, Q8IZ08, Q8NH39
    Conserved Domains (2) summary
    cd14964
    Location:139 → 161
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:120 → 398
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_017021598.3 → XP_016877087.1  G-protein coupled receptor 135 isoform X1

    UniProtKB/Swiss-Prot
    Q7Z604, Q86SM3, Q8IZ08, Q8NH39
    Conserved Domains (2) summary
    cd14964
    Location:139 → 161
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:120 → 398
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_024449696.2 → XP_024305464.1  G-protein coupled receptor 135 isoform X1

    UniProtKB/Swiss-Prot
    Q7Z604, Q86SM3, Q8IZ08, Q8NH39
    Conserved Domains (2) summary
    cd14964
    Location:139 → 161
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:120 → 398
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_024449695.2 → XP_024305463.1  G-protein coupled receptor 135 isoform X1

    UniProtKB/Swiss-Prot
    Q7Z604, Q86SM3, Q8IZ08, Q8NH39
    Conserved Domains (2) summary
    cd14964
    Location:139 → 161
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:120 → 398
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. XM_024449694.2 → XP_024305462.1  G-protein coupled receptor 135 isoform X1

    UniProtKB/Swiss-Prot
    Q7Z604, Q86SM3, Q8IZ08, Q8NH39
    Related
    ENSP00000432696.1, ENST00000481661.1
    Conserved Domains (2) summary
    cd14964
    Location:139 → 161
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:120 → 398
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  6. XM_024449693.2 → XP_024305461.1  G-protein coupled receptor 135 isoform X1

    UniProtKB/Swiss-Prot
    Q7Z604, Q86SM3, Q8IZ08, Q8NH39
    Conserved Domains (2) summary
    cd14964
    Location:139 → 161
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:120 → 398
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  7. XM_017021596.3 → XP_016877085.1  G-protein coupled receptor 135 isoform X1

    UniProtKB/Swiss-Prot
    Q7Z604, Q86SM3, Q8IZ08, Q8NH39
    Conserved Domains (2) summary
    cd14964
    Location:139 → 161
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:120 → 398
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    53659699..53672299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376614.1 → XP_054232589.1  G-protein coupled receptor 135 isoform X1

  2. XM_054376612.1 → XP_054232587.1  G-protein coupled receptor 135 isoform X1

  3. XM_054376613.1 → XP_054232588.1  G-protein coupled receptor 135 isoform X1

  4. XM_054376611.1 → XP_054232586.1  G-protein coupled receptor 135 isoform X1

  5. XM_054376609.1 → XP_054232584.1  G-protein coupled receptor 135 isoform X1

  6. XM_054376608.1 → XP_054232583.1  G-protein coupled receptor 135 isoform X1

  7. XM_054376610.1 → XP_054232585.1  G-protein coupled receptor 135 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZ08.2 GenPept UniProtKB/Swiss-Prot:Q8IZ08

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