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SUDS3 SDS3 homolog, SIN3A corepressor complex component [ Homo sapiens (human) ]

Gene ID: 64426, updated on 5-Mar-2024

Summary

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Official Symbol
SUDS3provided by HGNC
Official Full Name
SDS3 homolog, SIN3A corepressor complex componentprovided by HGNC
Primary source
HGNC:HGNC:29545
See related
Ensembl:ENSG00000111707 MIM:608250; AllianceGenome:HGNC:29545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDS3; SAP45
Summary
SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in thyroid (RPKM 8.3), testis (RPKM 7.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
12q24.23
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (118376555..118418033)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (118363824..118405300)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (118814360..118855838)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene TAO kinase 3 Neighboring gene ribosomal protein S2 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7110 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:118778991-118779218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7111 Neighboring gene uncharacterized LOC124903031 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:118814415-118814915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7112 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:118899925-118900083 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:118950661-118951161 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:118988007-118988217 Neighboring gene MPRA-validated peak1995 silencer Neighboring gene Sharpr-MPRA regulatory region 1346 Neighboring gene long intergenic non-protein coding RNA 2460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7113 Neighboring gene ribosomal protein L17 pseudogene 37

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Over-expression of the BRMS1 family member SUDS3 does not suppress metastasis of human cancer cells. Silveira AC, et al. Cancer Lett, 2009 Apr 8. PMID 19070953, Free PMC Article
  2. Hyaluronan binding motifs of USP17 and SDS3 exhibit anti-tumor activity. Ramakrishna S, et al. PLoS One, 2012. PMID 22662218, Free PMC Article
  3. TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population. Cook-Sather SD, et al. Pain, 2014 Sep. PMID 24909733, Free PMC Article
  4. SDS3 interacts with ARNT in an AhR ligand-specific manner regulating expression of cKrox and S100A4 in CD4+CD8+ DPK thymocytes differentiation. Lee DM, et al. Environ Toxicol Pharmacol, 2012 Nov. PMID 22981438
  5. Identification and characterization of three new components of the mSin3A corepressor complex. Fleischer TC, et al. Mol Cell Biol, 2003 May. PMID 12724404, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. studies reveal that loss of FAM60A or another component of the Sin3 complex, SDS3, leads to a change in cell morphology and an increase in cell migration
    Title: Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex.
  2. Our results have demonstrated that these hyaluronan binding motifs (HABMs) in USP17 and its substrate SDS3 are mainly involved in the inhibition of anchorage-independent tumor growth.
    Title: Hyaluronan binding motifs of USP17 and SDS3 exhibit anti-tumor activity.
  3. SDS3, being a substrate of USP17, may play an important role in developing a novel therapeutic means to inhibit specific HDAC activities in cancer.
    Title: Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.
  4. the composition of SIN3-HDAC (BRMS1/SUDS3) complexes uniquely affects protein expression and biological behaviors
    Title: Over-expression of the BRMS1 family member SUDS3 does not suppress metastasis of human cancer cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.
EBI GWAS Catalog
TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ00052, MGC104711

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to histone deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of cell migration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in substantia nigra development HEP PubMed 
Component Evidence Code Pubs
part_of Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Sin3-type complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
sin3 histone deacetylase corepressor complex component SDS3
Names
45 kDa Sin3-associated polypeptide
sin3A-associated protein, 45kDa
suppressor of defective silencing 3 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022491.3 → NP_071936.2  sin3 histone deacetylase corepressor complex component SDS3

    See identical proteins and their annotated locations for NP_071936.2

    Status: VALIDATED

    Source sequence(s)
    AA916093, AC026367, AK024460, BC098404
    Consensus CDS
    CCDS44993.1
    UniProtKB/Swiss-Prot
    Q4KMQ5, Q8N6H0, Q9H7L9, Q9H8D2
    Related
    ENSP00000443988.1, ENST00000543473.2
    Conserved Domains (1) summary
    pfam08598
    Location:62 → 178
    Sds3; Sds3-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    118376555..118418033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429355.1 → XP_047285311.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X1

  2. XM_017019817.2 → XP_016875306.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X2

  3. XM_047429356.1 → XP_047285312.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X3

  4. XM_047429357.1 → XP_047285313.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X4

  5. XM_047429358.1 → XP_047285314.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    118363824..118405300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372898.1 → XP_054228873.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X1

  2. XM_054372899.1 → XP_054228874.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X2

  3. XM_054372900.1 → XP_054228875.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X3

  4. XM_054372901.1 → XP_054228876.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X4

  5. XM_054372902.1 → XP_054228877.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H7L9.2 GenPept UniProtKB/Swiss-Prot:Q9H7L9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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