U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ACOT6 acyl-CoA thioesterase 6 [ Homo sapiens (human) ]

Gene ID: 641372, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ACOT6provided by HGNC
Official Full Name
acyl-CoA thioesterase 6provided by HGNC
Primary source
HGNC:HGNC:33159
See related
Ensembl:ENSG00000205669 MIM:614267; AllianceGenome:HGNC:33159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf42; c14_5530
Summary
Predicted to enable acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid metabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
14q24.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (73610945..73619888)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (67818457..67827400)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74077649..74086592)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene HEAT repeat containing 4 Neighboring gene tRNA-Lys (TTT) 14-1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:74058811-74059310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8704 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:74079399-74079898 Neighboring gene acyl-CoA thioesterase 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74080557-74080801 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:74083421-74084009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8706 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36549 Neighboring gene NADH:ubiquinone oxidoreductase subunit B8 pseudogene 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36559 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36561 Neighboring gene dynein axonemal light chain 1 Neighboring gene RNA, U6 small nuclear 240, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. Hunt MC, et al. J Lipid Res, 2005 Sep. PMID 16103133
  2. Exome sequencing supports a de novo mutational paradigm for schizophrenia. Xu B, et al. Nat Genet, 2011 Aug 7. PMID 21822266, Free PMC Article
  3. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. Hunt MC, et al. FASEB J, 2006 Sep. PMID 16940157
  4. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
  5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC161656, MGC161658

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acyl-CoA hydrolase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acyl-CoA metabolic process TAS
Traceable Author Statement
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisomal matrix TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
acyl-coenzyme A thioesterase 6
Names
putative acyl-CoA thioesterase 6
putative acyl-coenzyme A thioesterase 6
NP_001032239.1
NP_001352717.1
NP_001352718.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037162.1 → NP_001032239.1  acyl-coenzyme A thioesterase 6 isoform 2

    See identical proteins and their annotated locations for NP_001032239.1

    Status: VALIDATED

    Source sequence(s)
    DQ082756
    Consensus CDS
    CCDS32118.1
    UniProtKB/TrEMBL
    G3V3W6
    Related
    ENSP00000370531.1, ENST00000381139.1
    Conserved Domains (1) summary
    pfam08840
    Location:1 → 198
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

  2. NM_001365788.1 → NP_001352717.1  acyl-coenzyme A thioesterase 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005225
    Consensus CDS
    CCDS91900.1
    UniProtKB/Swiss-Prot
    A0A2R8Y7H3, Q3I5F7
    Related
    ENSP00000496277.1, ENST00000645972.2
    Conserved Domains (2) summary
    pfam04775
    Location:16 → 137
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
    pfam08840
    Location:203 → 412
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

  3. NM_001365789.1 → NP_001352718.1  acyl-coenzyme A thioesterase 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005225
    Consensus CDS
    CCDS32118.1
    UniProtKB/TrEMBL
    G3V3W6
    Related
    ENSP00000451464.1, ENST00000554229.1
    Conserved Domains (1) summary
    pfam08840
    Location:1 → 198
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    73610945..73619888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    67818457..67827400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3I5F7.2 GenPept UniProtKB/Swiss-Prot:Q3I5F7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous