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BGN biglycan [ Homo sapiens (human) ]

Gene ID: 633, updated on 3-Apr-2024

Summary

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Official Symbol
BGNprovided by HGNC
Official Full Name
biglycanprovided by HGNC
Primary source
HGNC:HGNC:1044
See related
Ensembl:ENSG00000182492 MIM:301870; AllianceGenome:HGNC:1044
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGI; MRLS; DSPG1; PG-S1; SEMDX; SLRR1A
Summary
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]
Expression
Broad expression in gall bladder (RPKM 206.5), spleen (RPKM 159.3) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
Xq28
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (153494980..153509546)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (151768553..151783109)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (152760438..152775004)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene three prime repair exonuclease 2 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:152726424-152726582 Neighboring gene HAUS augmin like complex subunit 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30034 Neighboring gene Sharpr-MPRA regulatory region 9358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152741433-152741972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152742168-152742668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152742669-152743169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152753877-152754691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152756808-152757380 Neighboring gene extracellular matrix protein X-linked, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30035 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30036 Neighboring gene ATPase plasma membrane Ca2+ transporting 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152809330-152810182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152825847-152826631 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152831014-152831626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21064 Neighboring gene cyclin Q

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Stroma biglycan expression can be a prognostic factor in prostate cancers. Furumido J, et al. Int J Urol, 2023 Feb. PMID 36305810
  2. Expression and prognostic analysis of BGN in head and neck squamous cell carcinoma. Zhao L, et al. Gene, 2022 Jun 15. PMID 35358652
  3. Identification of Differentially Expressed Genes Reveals BGN Predicting Overall Survival and Tumor Immune Infiltration of Gastric Cancer. Chen W, et al. Comput Math Methods Med, 2021. PMID 34868341, Free PMC Article
  4. Biglycan: an emerging small leucine-rich proteoglycan (SLRP) marker and its clinicopathological significance. Appunni S, et al. Mol Cell Biochem, 2021 Nov. PMID 34181183
  5. Identification of a novel miR-21-3p/TGF-β signaling-driven immune escape via the MHC class I/biglycan axis in tumor cells. Subbarayan K, et al. Clin Transl Med, 2021 Mar. PMID 33783999, Free PMC Article

See all (159) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long noncoding RNA ZEB1-AS1 attenuates ferroptosis of gastric cancer cells through modulating miR-429/BGN axis.
    Title: Long noncoding RNA ZEB1-AS1 attenuates ferroptosis of gastric cancer cells through modulating miR-429/BGN axis.
  2. Stroma biglycan expression can be a prognostic factor in prostate cancers.
    Title: Stroma biglycan expression can be a prognostic factor in prostate cancers.
  3. Biglycan promotes hepatic fibrosis through activating heat shock protein 47.
    Title: Biglycan promotes hepatic fibrosis through activating heat shock protein 47.
  4. Identification of BGN and THBS2 as metastasis-specific biomarkers and poor survival key regulators in human colon cancer by integrated analysis.
    Title: Identification of BGN and THBS2 as metastasis-specific biomarkers and poor survival key regulators in human colon cancer by integrated analysis.
  5. Expression and prognostic analysis of BGN in head and neck squamous cell carcinoma.
    Title: Expression and prognostic analysis of BGN in head and neck squamous cell carcinoma.
  6. Identification of Differentially Expressed Genes Reveals BGN Predicting Overall Survival and Tumor Immune Infiltration of Gastric Cancer.
    Title: Identification of Differentially Expressed Genes Reveals BGN Predicting Overall Survival and Tumor Immune Infiltration of Gastric Cancer.
  7. Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis: the iPOWER Study.
    Title: Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis: the iPOWER Study.
  8. Biglycan: an emerging small leucine-rich proteoglycan (SLRP) marker and its clinicopathological significance.
    Title: Biglycan: an emerging small leucine-rich proteoglycan (SLRP) marker and its clinicopathological significance.
  9. Identification of a novel miR-21-3p/TGF-beta signaling-driven immune escape via the MHC class I/biglycan axis in tumor cells.
    Title: Identification of a novel miR-21-3p/TGF-β signaling-driven immune escape via the MHC class I/biglycan axis in tumor cells.
  10. Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy.
    Title: Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy.
Submit: New GeneRIF Correction See all GeneRIFs (101)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Meester-Loeys syndrome
MedGen: C4310811 OMIM: 300989 GeneReviews: Heritable Thoracic Aortic Disease Overview
Compare labs
X-linked spondyloepimetaphyseal dysplasia
MedGen: C1848097 OMIM: 300106 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine binding IEA
Inferred from Electronic Annotation
more info
  
enables extracellular matrix binding IEA
Inferred from Electronic Annotation
more info
  
enables extracellular matrix structural constituent NAS
Non-traceable Author Statement
more info
 PubMed 
enables extracellular matrix structural constituent conferring compression resistance ISS
Inferred from Sequence or Structural Similarity
more info
  
enables extracellular matrix structural constituent conferring compression resistance RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables glycosaminoglycan binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in articular cartilage development IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in bone development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
colocalizes_with collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular matrix NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular region HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal lumen TAS
Traceable Author Statement
more info
  
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
  
located_in transport vesicle IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
biglycan
Names
bone/cartilage proteoglycan-I
dermatan sulphate proteoglycan I
small leucine-rich protein 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015961.1 RefSeqGene

    Range
    5028..19594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001711.6 → NP_001702.1  biglycan preproprotein

    See identical proteins and their annotated locations for NP_001702.1

    Status: REVIEWED

    Source sequence(s)
    AI538325, AK297966, BC002416, BQ180984, DC299956
    Consensus CDS
    CCDS14721.1
    UniProtKB/Swiss-Prot
    D3DWU3, P13247, P21810
    UniProtKB/TrEMBL
    A8K7E0, Q53FI4
    Related
    ENSP00000327336.4, ENST00000331595.9
    Conserved Domains (4) summary
    sd00031
    Location:302 → 315
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:71 → 91
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:277 → 323
    LRR_8; Leucine rich repeat
    cl26018
    Location:64 → 297
    NEL; C-terminal novel E3 ligase, LRR-interacting

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    153494980..153509546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029724.3 → XP_016885213.1  biglycan isoform X1

    UniProtKB/Swiss-Prot
    D3DWU3, P13247, P21810
    UniProtKB/TrEMBL
    A8K7E0, Q53FI4
    Conserved Domains (4) summary
    sd00031
    Location:302 → 315
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:71 → 91
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:277 → 323
    LRR_8; Leucine rich repeat
    cl26018
    Location:64 → 297
    NEL; C-terminal novel E3 ligase, LRR-interacting

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    151768553..151783109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327563.1 → XP_054183538.1  biglycan isoform X1

    UniProtKB/Swiss-Prot
    D3DWU3, P13247, P21810
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21810.2 GenPept UniProtKB/Swiss-Prot:P21810

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