RPS6KB2 ribosomal protein S6 kinase B2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RPS6KB2provided by HGNC
Official Full Name: ribosomal protein S6 kinase B2provided by HGNC
Primary source: HGNC:HGNC:10437
See related: Ensembl:ENSG00000175634 MIM:608939; AllianceGenome:HGNC:10437
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KLS; SRK; S6K2; S6KB; STK14B; S6KI(2); S6Kbeta; p70S6Kb; P70-beta; S6K-beta2; P70-beta-1; P70-beta-2; p70(S6K)-beta
Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]
Expression: Ubiquitous expression in skin (RPKM 31.3), esophagus (RPKM 20.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.2

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (67428494..67435401)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (67422609..67429517)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (67195965..67202872)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ribosomal protein S6 kinase 2 (RPS6KB2) is a potential immunotherapeutic target for cancer that upregulates proinflammatory cytokines.
Title: Ribosomal protein S6 kinase 2 (RPS6KB2) is a potential immunotherapeutic target for cancer that upregulates proinflammatory cytokines.
NSUN6, an RNA methyltransferase of 5-mC controls glioblastoma response to temozolomide (TMZ) via NELFB and RPS6KB2 interaction.
Title: NSUN6, an RNA methyltransferase of 5-mC controls glioblastoma response to temozolomide (TMZ) via NELFB and RPS6KB2 interaction.
Circ-GLI1 promotes metastasis in melanoma through interacting with p70S6K2 to activate Hedgehog/GLI1 and Wnt/beta-catenin pathways and upregulate Cyr61.
Title: Circ-GLI1 promotes metastasis in melanoma through interacting with p70S6K2 to activate Hedgehog/GLI1 and Wnt/β-catenin pathways and upregulate Cyr61.
Activation of Mechanistic Target of Rapamycin (mTOR) in Human Endothelial Cells Infected with Pathogenic Spotted Fever Group Rickettsiae.
Title: Activation of Mechanistic Target of Rapamycin (mTOR) in Human Endothelial Cells Infected with Pathogenic Spotted Fever Group Rickettsiae.
Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer.
Title: Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer.
The results suggest that although the polyproline region of S6K2 is capable of generating ribosomal stalling, the depletion of eIF5A in HeLa cells seems to be insufficient to cause an expressive decrease in the content of endogenous S6K2.
Title: The polyproline-motif of S6K2: eIF5A translational dependence and importance for protein-protein interactions.
Role of S6K2 in cancer cell survival.[review]
Title: S6K2 promises an important therapeutic potential for cancer.
p54-S6K2 interactome is predominant to the nucleus, whereas p70-S6K1 is predominant to cytosol.
Title: Different interactomes for p70-S6K1 and p54-S6K2 revealed by proteomic analysis.
Overexpression of catalytically-active Akt or knockdown of glycogen synthase kinase-3 (GSK3)-beta, a substrate for Akt, had little effect on Mcl-1 downregulation caused by S6K2 deficiency
Title: Regulation of anti-apoptotic Bcl-2 family protein Mcl-1 by S6 kinase 2.
We propose that the S6K2/TRBP node controls miRNA biogenesis in HDLECs and provides a molecular link between the mTOR pathway and the miRNA biogenesis machinery.
Title: S6K2-mediated regulation of TRBP as a determinant of miRNA expression in human primary lymphatic endothelial cells.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with p70S6Kb	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:434012 (e-PCR)
- UniSTS:157204

GDB:312794 (e-PCR)
- UniSTS:30247

L17705 (e-PCR)
- UniSTS:66091

D8S2279 (e-PCR)
- UniSTS:473907

RH41895 (e-PCR)
- UniSTS:58426

D10S16 (e-PCR)
- UniSTS:155756

NoName (e-PCR)
- UniSTS:484727

STS-X97267 (e-PCR)
- UniSTS:10616

L17877 (e-PCR)
- UniSTS:61334

L17809 (e-PCR)
- UniSTS:39087

NoName (e-PCR)
- UniSTS:494813

D11S3316 (e-PCR)
- UniSTS:152558

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables peptide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in translation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: ribosomal protein S6 kinase beta-2

Names: 70 kDa ribosomal protein S6 kinase 2; P70S6K2; S6 kinase-related kinase; S6K-beta; S6K-beta-2; p70 S6 kinase beta; p70 S6K-beta; p70 S6KB; p70 ribosomal S6 kinase beta; p70-S6K 2; ribosomal protein S6 kinase, 70kDa, polypeptide 2; serine/threonine-protein kinase 14 beta; serine/threonine-protein kinase 14B

NP_003943.2

EC 2.7.11.1

XP_006718719.1

EC 2.7.11.1

XP_047283351.1

EC 2.7.11.1

XP_047283352.1

EC 2.7.11.1

XP_054225588.1

EC 2.7.11.1

XP_054225589.1

EC 2.7.11.1

XP_054225590.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003952.3 → NP_003943.2 ribosomal protein S6 kinase beta-2

See identical proteins and their annotated locations for NP_003943.2

Status: REVIEWED

Source sequence(s)

AB019245, AP003419, BX337895, BX538119

Consensus CDS

CCDS41677.1

UniProtKB/Swiss-Prot

B2RMZ9, B4DML8, O94809, Q9UBS0, Q9UEC1

UniProtKB/TrEMBL

Q9BRS0

Related

ENSP00000308413.5, ENST00000312629.10

Conserved Domains (2) summary

smart00220
Location:67 → 328

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05584
Location:70 → 392

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

67428494..67435401

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047427395.1 → XP_047283351.1 ribosomal protein S6 kinase beta-2 isoform X1
XM_047427396.1 → XP_047283352.1 ribosomal protein S6 kinase beta-2 isoform X3
XM_006718656.4 → XP_006718719.1 ribosomal protein S6 kinase beta-2 isoform X2

See identical proteins and their annotated locations for XP_006718719.1

Conserved Domains (1) summary

cl21453
Location:1 → 192

PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

67422609..67429517

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054369613.1 → XP_054225588.1 ribosomal protein S6 kinase beta-2 isoform X1
XM_054369615.1 → XP_054225590.1 ribosomal protein S6 kinase beta-2 isoform X3
XM_054369614.1 → XP_054225589.1 ribosomal protein S6 kinase beta-2 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001007071.1: Suppressed sequence

Description

NM_001007071.1: This RefSeq was permanently suppressed because because currently there is insufficient support for the transcript, and it is a nonsense-mediated mRNA decay (NMD) candidate.