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RPL15 ribosomal protein L15 [ Homo sapiens (human) ]

Gene ID: 6138, updated on 11-Apr-2024

Summary

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Official Symbol
RPL15provided by HGNC
Official Full Name
ribosomal protein L15provided by HGNC
Primary source
HGNC:HGNC:10306
See related
Ensembl:ENSG00000174748 MIM:604174; AllianceGenome:HGNC:10306
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L15; EC45; eL15; DBA12; RPL10; RPLY10; RPYL10
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]
Expression
Ubiquitous expression in ovary (RPKM 335.5), thyroid (RPKM 183.2) and 25 other tissues See more
Orthologs
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Genomic context

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See RPL15 in Genome Data Viewer
Location:
3p24.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (23916545..23924631)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (23921321..23929407)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (23958036..23966122)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19600 Neighboring gene UBE2E1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14144 Neighboring gene ubiquitin conjugating enzyme E2 E1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19605 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:23906443-23907202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:23924271-23924855 Neighboring gene ADP ribosylation factor like GTPase 4A pseudogene 4 Neighboring gene NFKB inhibitor interacting Ras like 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:23958136-23959335 Neighboring gene uncharacterized LOC124909354 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:23987327-23987868 Neighboring gene Sharpr-MPRA regulatory region 12700 Neighboring gene nuclear receptor subfamily 1 group D member 2 Neighboring gene MPRA-validated peak4577 silencer

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Overexpressed circ-RPL15 predicts poor survival and promotes the progression of gastric cancer via regulating miR-502-3p/OLFM4/STAT3 pathway. Li Y, et al. Biomed Pharmacother, 2020 Jul. PMID 32559850
  2. Circ-RPL15: a plasma circular RNA as novel oncogenic driver to promote progression of chronic lymphocytic leukemia. Wu Z, et al. Leukemia, 2020 Mar. PMID 31611623
  3. Ribosomal Protein L15 is involved in Colon Carcinogenesis. Dong Z, et al. Int J Med Sci, 2019. PMID 31523176, Free PMC Article
  4. Recurring mutations in RPL15 are linked to hydrops fetalis and treatment independence in Diamond-Blackfan anemia. Wlodarski MW, et al. Haematologica, 2018 Jun. PMID 29599205, Free PMC Article
  5. Identification of Differentially Expressed Genes through Integrated Study of Alzheimer's Disease Affected Brain Regions. Puthiyedth N, et al. PLoS One, 2016. PMID 27050411, Free PMC Article

See all (197) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Decreased expression of RPL15 and RPL18 exacerbated the calcification of valve interstitial cells during aortic valve calcification.
    Title: Decreased expression of RPL15 and RPL18 exacerbated the calcification of valve interstitial cells during aortic valve calcification.
  2. Detection of mRNAs of Ribosomal Protein L15 and E-Cadherin in Living Circulating Tumor Cells at Single Cell Resolution To Study Tumor Heterogeneity.
    Title: Detection of mRNAs of Ribosomal Protein L15 and E-Cadherin in Living Circulating Tumor Cells at Single Cell Resolution To Study Tumor Heterogeneity.
  3. Identification of Potential Biomarkers for Intervertebral Disc Degeneration Using the Genome-Wide Expression Analysis.
    Title: Identification of Potential Biomarkers for Intervertebral Disc Degeneration Using the Genome-Wide Expression Analysis.
  4. Overexpressed circ-RPL15 predicts poor survival and promotes the progression of gastric cancer via regulating miR-502-3p/OLFM4/STAT3 pathway.
    Title: Overexpressed circ-RPL15 predicts poor survival and promotes the progression of gastric cancer via regulating miR-502-3p/OLFM4/STAT3 pathway.
  5. Circ-RPL15: a plasma circular RNA as novel oncogenic driver to promote progression of chronic lymphocytic leukemia.
    Title: Circ-RPL15: a plasma circular RNA as novel oncogenic driver to promote progression of chronic lymphocytic leukemia.
  6. RPL15 is required for maintaining normal nucleolar structure. RPL15 is involved in human colon carcinogenesis.RPL15 is overexpressed in colon cancer.
    Title: Ribosomal Protein L15 is involved in Colon Carcinogenesis.
  7. This study identifies a novel subgroup of DBA with mutations in the RPL15 gene with an unexpected high rate of hydrops fetalis and spontaneous, long-lasting remission.
    Title: Recurring mutations in RPL15 are linked to hydrops fetalis and treatment independence in Diamond-Blackfan anemia.
  8. Aurora kinase inhibitor danusertib negatively regulated AURKB/p70S6K/RPL15 axis with the involvement of PI3K/Akt/mTOR, AMPK, and p38 MAPK signaling pathways, leading to the induction of apoptosis and autophagy in human leukemia cells.
    Title: Inhibition of Aurora kinases induces apoptosis and autophagy via AURKB/p70S6K/RPL15 axis in human leukemia cells.
  9. Downregulation of RPL15 is associated with tumor progression in pancreatic ductal adenocarcinoma.
    Title: Downregulation of RPL15 may predict poor survival and associate with tumor progression in pancreatic ductal adenocarcinoma.
  10. These data identify RPL15 as a new gene involved in Diamond-Blackfan anemia.
    Title: Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Diamond-Blackfan anemia 12
MedGen: C3809888 OMIM: 615550 GeneReviews: Diamond-Blackfan Anemia
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2014-07-16)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2014-07-16)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ26304, MGC88603

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
  
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in A band IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit HDA PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ribosome TAS
Traceable Author Statement
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein eL15
Names
60S ribosomal protein L15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033850.2 RefSeqGene

    Range
    5588..9445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1152

mRNA and Protein(s)

  1. NM_001253379.2 → NP_001240308.1  large ribosomal subunit protein eL15 isoform 1

    See identical proteins and their annotated locations for NP_001240308.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
    Source sequence(s)
    AC124914, AI886077, BI544251, DA037869
    Consensus CDS
    CCDS2640.1
    UniProtKB/Swiss-Prot
    P39030, P41051, P61313, Q5U0C0, Q642I1, Q6IPX6, Q8WYP2, Q96C44, Q9H2E5
    UniProtKB/TrEMBL
    E7EQV9
    Related
    ENSP00000483260.1, ENST00000611050.4
    Conserved Domains (1) summary
    pfam00827
    Location:2 → 191
    Ribosomal_L15e; Ribosomal L15

  2. NM_001253380.2 → NP_001240309.1  large ribosomal subunit protein eL15 isoform 1

    See identical proteins and their annotated locations for NP_001240309.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
    Source sequence(s)
    AC124914, AI886077, AY347528, DB461802
    Consensus CDS
    CCDS2640.1
    UniProtKB/Swiss-Prot
    P39030, P41051, P61313, Q5U0C0, Q642I1, Q6IPX6, Q8WYP2, Q96C44, Q9H2E5
    UniProtKB/TrEMBL
    E7EQV9
    Related
    ENSP00000346867.5, ENST00000354811.5
    Conserved Domains (1) summary
    pfam00827
    Location:2 → 191
    Ribosomal_L15e; Ribosomal L15

  3. NM_001253382.2 → NP_001240311.1  large ribosomal subunit protein eL15 isoform 1

    See identical proteins and their annotated locations for NP_001240311.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
    Source sequence(s)
    AC124914, AI886077, BE893727, BU178524
    Consensus CDS
    CCDS2640.1
    UniProtKB/Swiss-Prot
    P39030, P41051, P61313, Q5U0C0, Q642I1, Q6IPX6, Q8WYP2, Q96C44, Q9H2E5
    UniProtKB/TrEMBL
    E7EQV9
    Related
    ENSP00000493759.1, ENST00000644185.1
    Conserved Domains (1) summary
    pfam00827
    Location:2 → 191
    Ribosomal_L15e; Ribosomal L15

  4. NM_001253383.3 → NP_001240312.1  large ribosomal subunit protein eL15 isoform 1

    See identical proteins and their annotated locations for NP_001240312.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
    Source sequence(s)
    AC124914, DA205054, DC351786
    Consensus CDS
    CCDS2640.1
    UniProtKB/Swiss-Prot
    P39030, P41051, P61313, Q5U0C0, Q642I1, Q6IPX6, Q8WYP2, Q96C44, Q9H2E5
    UniProtKB/TrEMBL
    E7EQV9
    Related
    ENSP00000416692.1, ENST00000413699.7
    Conserved Domains (1) summary
    pfam00827
    Location:2 → 191
    Ribosomal_L15e; Ribosomal L15

  5. NM_001253384.2 → NP_001240313.1  large ribosomal subunit protein eL15 isoform 2

    See identical proteins and their annotated locations for NP_001240313.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) includes an alternate exon in the 3' UTR and coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC124914, BC081565, BI544251
    Consensus CDS
    CCDS58818.1
    UniProtKB/TrEMBL
    E7EX53
    Related
    ENSP00000398788.2, ENST00000456530.7
    Conserved Domains (1) summary
    cl02977
    Location:2 → 120
    Ribosomal_L15e; Ribosomal L15

  6. NM_002948.5 → NP_002939.2  large ribosomal subunit protein eL15 isoform 1

    See identical proteins and their annotated locations for NP_002939.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-5 encode the same isoform (1).
    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS2640.1
    UniProtKB/Swiss-Prot
    P39030, P41051, P61313, Q5U0C0, Q642I1, Q6IPX6, Q8WYP2, Q96C44, Q9H2E5
    UniProtKB/TrEMBL
    E7EQV9
    Related
    ENSP00000309334.5, ENST00000307839.10
    Conserved Domains (1) summary
    pfam00827
    Location:2 → 191
    Ribosomal_L15e; Ribosomal L15

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    23916545..23924631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    23921321..23929407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61313.2 GenPept UniProtKB/Swiss-Prot:P61313

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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