ROBO2 roundabout guidance receptor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ROBO2provided by HGNC
Official Full Name: roundabout guidance receptor 2provided by HGNC
Primary source: HGNC:HGNC:10250
See related: Ensembl:ENSG00000185008 MIM:602431; AllianceGenome:HGNC:10250
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SAX3
Summary: The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Expression: Broad expression in brain (RPKM 5.1), lung (RPKM 2.8) and 14 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3p12.3

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (75906675..77649964)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (75959914..77704808)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (75955826..77699115)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SALL4 advances the proliferation and tumor cell stemness of colon cancer cells through the transcription and regulation of ROBO2.
Title: SALL4 advances the proliferation and tumor cell stemness of colon cancer cells through the transcription and regulation of ROBO2.
Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding.
Title: Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding.
An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations.
Title: An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations.
ROBO2 hampers malignant biological behavior and predicts a better prognosis in pancreatic adenocarcinoma.
Title: ROBO2 hampers malignant biological behavior and predicts a better prognosis in pancreatic adenocarcinoma.
Investigation of DNA variants specific to ROBO2 Isoform 'a' in Irish vesicoureteric reflux patients reveals marked CpG island variation.
Title: Investigation of DNA variants specific to ROBO2 Isoform 'a' in Irish vesicoureteric reflux patients reveals marked CpG island variation.
The gene ROBO2 was decreased in patients with COPD and this decrease was significantly negatively correlated with the disease stages of COPD
Title: Roundabout signaling pathway involved in the pathogenesis of COPD by integrative bioinformatics analysis.
results suggest that Robo2 functions as a receptor for NELL1/2, particularly under circumstances where Robo2 undergoes proteolytic digestion
Title: Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2.
determined the crystal structure of the tandem Ig4-5 domains (D4-5) of human Robo2 and found that a hydrophobic surface on D4 mediates close homotypic contacts with a reciprocal D4
Title: Robo Ig4 Is a Dimerization Domain.
human placental multipotent mesenchymal stromal cell express Slit2 and both Robo1 and Robo4 are present in human umbilical vein endothelial cells.
Title: Human placental multipotent mesenchymal stromal cells modulate placenta angiogenesis through Slit2-Robo signaling.
ROBO2 variants were not found to be associated with nonsyndromic vesicoureteral reflux with or without renal hypoplasia/dysplasia, providing further evidence for genetic heterogeneity
Title: ROBO2 gene variants in children with primary nonsyndromic vesicoureteral reflux with or without renal hypoplasia/dysplasia.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Vesicoureteral reflux 2 MedGen: C1970483 OMIM: 610878 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common variation near ROBO2 is associated with expressive vocabulary in infancy. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variants associated with disordered eating. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of chronic periodontitis in a general German population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. EBI GWAS Catalog EBI GWAS CatalogPubMed
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH121074 (e-PCR)
- UniSTS:132361

WI-11153 (e-PCR)
- UniSTS:35339

Z94483 (e-PCR)
- UniSTS:12047

STS-Z41295 (e-PCR)
- UniSTS:82711

G32429 (e-PCR)
- UniSTS:117016

RH71142 (e-PCR)
- UniSTS:3609

SHGC-144609 (e-PCR)
- UniSTS:172313

Z94676 (e-PCR)
- UniSTS:53532

RH121809 (e-PCR)
- UniSTS:134958

G19155 (e-PCR)
- UniSTS:22063

D3S3392 (e-PCR)
- UniSTS:26934

D3S2484 (e-PCR)
- UniSTS:20280

ATC-P7546 (e-PCR)
- UniSTS:59452

SHGC-111835 (e-PCR)
- UniSTS:168775

HSC2MC092 (e-PCR)
- UniSTS:52564

D3S3653 (e-PCR), detects polymorphism
- UniSTS:34903

SHGC-112056 (e-PCR)
- UniSTS:183639

SHGC-149006 (e-PCR)
- UniSTS:176735

WI-11200 (e-PCR)
- UniSTS:28008

SHGC-77113 (e-PCR)
- UniSTS:71274

D3S4157 (e-PCR)
- UniSTS:36971

G62910 (e-PCR)
- UniSTS:139885

SHGC-34465 (e-PCR)
- UniSTS:7279

RH120835 (e-PCR)
- UniSTS:133490

D3S2515 (e-PCR)
- UniSTS:150131

D3S2517 (e-PCR)
- UniSTS:150133

D3S1747 (e-PCR)
- UniSTS:148604

STS-N33966 (e-PCR)
- UniSTS:14720

SHGC-152513 (e-PCR)
- UniSTS:177537

D3S2533 (e-PCR)
- UniSTS:150149

D3S2534 (e-PCR)
- UniSTS:150150

D3S3289E (e-PCR)
- UniSTS:153734

D3S2536 (e-PCR)
- UniSTS:150152

D3S2537 (e-PCR)
- UniSTS:150153

D3S2538 (e-PCR)
- UniSTS:150154

D3S2539 (e-PCR)
- UniSTS:150155

SHGC-112264 (e-PCR)
- UniSTS:168587

D3S2540 (e-PCR)
- UniSTS:150156

RH104380 (e-PCR)
- UniSTS:98705

SHGC-85303 (e-PCR)
- UniSTS:104854

RH118648 (e-PCR)
- UniSTS:138141

WI-14397 (e-PCR)
- UniSTS:42909

D3S769 (e-PCR)
- UniSTS:147614

SHGC-154474 (e-PCR)
- UniSTS:183710

SHGC-77102 (e-PCR)
- UniSTS:19362

SHGC-84705 (e-PCR)
- UniSTS:104101

G59185 (e-PCR)
- UniSTS:136358

RH70334 (e-PCR)
- UniSTS:29355

A009C42 (e-PCR)
- UniSTS:39856

RH123221 (e-PCR)
- UniSTS:135606

SHGC-84730 (e-PCR)
- UniSTS:104124

SHGC-81121 (e-PCR)
- UniSTS:102339

D3S4533 (e-PCR)
- UniSTS:51651

G59485 (e-PCR)
- UniSTS:136649

G63118 (e-PCR)
- UniSTS:140237

G63119 (e-PCR)
- UniSTS:140238

RH118691 (e-PCR)
- UniSTS:138191

RH121580 (e-PCR)
- UniSTS:134352

G16647 (e-PCR)
- UniSTS:7378

SHGC-148764 (e-PCR)
- UniSTS:176594

SHGC-77120 (e-PCR)
- UniSTS:28628

SHGC-78827 (e-PCR)
- UniSTS:100825

SHGC-145417 (e-PCR)
- UniSTS:174564

D3S3365 (e-PCR)
- UniSTS:76517

SHGC-148375 (e-PCR)
- UniSTS:176358

SHGC-105189 (e-PCR)
- UniSTS:169199

G59525 (e-PCR)
- UniSTS:136688

RH80480 (e-PCR)
- UniSTS:92402

RH123802 (e-PCR)
- UniSTS:136179

SHGC-145851 (e-PCR)
- UniSTS:174836

ROBO2 (e-PCR)
- UniSTS:279030

SHGC-81280 (e-PCR)
- UniSTS:102653

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables axon guidance receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables axon guidance receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in aorta development	ISS Inferred from Sequence or Structural Similarity more info
involved_in aortic valve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process involved in luteolysis	IEP Inferred from Expression Pattern more info	PubMed
involved_in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in axon midline choice point recognition	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in central nervous system development	NAS Non-traceable Author Statement more info	PubMed
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in endocardial cushion formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart induction	ISS Inferred from Sequence or Structural Similarity more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in metanephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of negative chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in olfactory bulb interneuron development	ISS Inferred from Sequence or Structural Similarity more info
involved_in outflow tract septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in pulmonary valve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinal ganglion cell axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in ureteric bud development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axolemma	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

Go to the top of the page Help

Preferred Names: roundabout homolog 2

Names: roundabout, axon guidance receptor, homolog 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_027734.2 RefSeqGene

Range

1138406..1748271

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001128929.3 → NP_001122401.1 roundabout homolog 2 isoform ROBO2a precursor

See identical proteins and their annotated locations for NP_001122401.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the use of an alternate promoter and has multiple differences compared to variant 4. These differences result in a distinct 5' UTR and the use of an alternate start codon compared to variant 4. The encoded protein (isoform ROBO2a; PMID 16829019) has a distinct N-terminus and is shorter than isoform 4.

Source sequence(s)

AC126467, AC133040, DQ533873

Consensus CDS

CCDS54609.1

UniProtKB/Swiss-Prot

Q9HCK4

Related

ENSP00000417335.2, ENST00000487694.7

Conserved Domains (7) summary

cd00096
Location:451 → 518

Ig; Immunoglobulin domain

cd05726
Location:344 → 433

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:46 → 145

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

smart00410
Location:440 → 521

IG_like; Immunoglobulin like

cd00063
Location:538 → 631

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:241 → 326

I-set; Immunoglobulin I-set domain

cl11960
Location:153 → 237

Ig; Immunoglobulin domain
NM_001290039.2 → NP_001276968.1 roundabout homolog 2 isoform 3 precursor

See identical proteins and their annotated locations for NP_001276968.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 4. The encoded protein (isoform 3) is shorter than variant 4.

Source sequence(s)

AC117515, AC117516, AC133040, BC144306, DQ533874

UniProtKB/Swiss-Prot

Q9HCK4

Conserved Domains (7) summary

cd00096
Location:439 → 506

Ig; Immunoglobulin domain

cd05726
Location:332 → 421

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:30 → 129

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

smart00410
Location:428 → 509

IG_like; Immunoglobulin like

cd00063
Location:526 → 619

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:225 → 310

I-set; Immunoglobulin I-set domain

cl11960
Location:137 → 221

Ig; Immunoglobulin domain
NM_001290040.2 → NP_001276969.1 roundabout homolog 2 isoform 4 precursor

See identical proteins and their annotated locations for NP_001276969.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).

Source sequence(s)

AC117515, AC133040, BC144303, DQ533874

Consensus CDS

CCDS93318.1

UniProtKB/TrEMBL

F8W703

Related

ENSP00000327536.9, ENST00000332191.13

Conserved Domains (7) summary

cd00096
Location:439 → 506

Ig; Immunoglobulin domain

cd05726
Location:332 → 421

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:30 → 129

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

smart00410
Location:428 → 509

IG_like; Immunoglobulin like

cd00063
Location:526 → 619

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:225 → 310

I-set; Immunoglobulin I-set domain

cl11960
Location:137 → 221

Ig; Immunoglobulin domain
NM_001290065.2 → NP_001276994.1 roundabout homolog 2 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) has multiple differences compared to variant 4. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon compared to variant 4; the 5'-most initiation codon, as used in variant 4, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG resulting in an isoform (5) with a shorter N-terminus compared to isoform 4.

Source sequence(s)

AC117515, AC133040, BC144302, DQ533874

UniProtKB/Swiss-Prot

Q9HCK4

Conserved Domains (1) summary

cd00063
Location:147 → 239

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001378190.1 → NP_001365119.1 roundabout homolog 2 isoform 6 precursor

Status: REVIEWED

Source sequence(s)

AC117515, AC117516, AC126467, AC133040

Conserved Domains (6) summary

cd00063
Location:542 → 635

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:152 → 155

Ig; Ig strand A [structural motif]

cd05726
Location:335 → 432

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:47 → 145

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:439 → 525

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:152 → 237

Ig; Immunoglobulin domain
NM_001378191.1 → NP_001365120.1 roundabout homolog 2 isoform 7 precursor

Status: REVIEWED

Source sequence(s)

AC117515, AC117516, AC126467, AC133040

Consensus CDS

CCDS93314.1

UniProtKB/TrEMBL

A0A8Q3SIW8

Related

ENSP00000512767.1, ENST00000696630.1

Conserved Domains (6) summary

cd00063
Location:542 → 635

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:152 → 155

Ig; Ig strand A [structural motif]

cd05726
Location:335 → 432

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:47 → 145

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:439 → 525

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:152 → 237

Ig; Immunoglobulin domain
NM_001378192.1 → NP_001365121.1 roundabout homolog 2 isoform 8 precursor

Status: REVIEWED

Source sequence(s)

AC067717, AC117515, AC117516, AC133040

Conserved Domains (6) summary

cd00063
Location:549 → 642

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:159 → 162

Ig; Ig strand A [structural motif]

cd05726
Location:342 → 439

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:54 → 152

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:446 → 532

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:159 → 244

Ig; Immunoglobulin domain
NM_001378193.1 → NP_001365122.1 roundabout homolog 2 isoform 9 precursor

Status: REVIEWED

Source sequence(s)

AC117515, AC117516, AC133040

Consensus CDS

CCDS93321.1

UniProtKB/TrEMBL

H7C4J7

Related

ENSP00000417471.2, ENST00000490534.2

Conserved Domains (6) summary

cd00063
Location:522 → 615

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:136 → 139

Ig; Ig strand A [structural motif]

cd05726
Location:315 → 412

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:31 → 129

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:419 → 505

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:136 → 221

Ig; Immunoglobulin domain
NM_001378194.1 → NP_001365123.1 roundabout homolog 2 isoform 10 precursor

Status: REVIEWED

Source sequence(s)

AC067717, AC117515, AC117516, AC133040

Conserved Domains (6) summary

cd00063
Location:549 → 642

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:159 → 162

Ig; Ig strand A [structural motif]

cd05726
Location:342 → 439

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:54 → 152

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:446 → 532

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:159 → 244

Ig; Immunoglobulin domain
NM_001378195.1 → NP_001365124.1 roundabout homolog 2 isoform 11 precursor

Status: REVIEWED

Source sequence(s)

AC117515, AC117516, AC126467, AC133040

Consensus CDS

CCDS93316.1

UniProtKB/TrEMBL

A0A8Q3SIU0

Related

ENSP00000512766.1, ENST00000696629.1

Conserved Domains (6) summary

cd00063
Location:542 → 635

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:152 → 155

Ig; Ig strand A [structural motif]

cd05726
Location:335 → 432

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:47 → 145

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:439 → 525

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:152 → 237

Ig; Immunoglobulin domain
NM_001378196.1 → NP_001365125.1 roundabout homolog 2 isoform 12 precursor

Status: REVIEWED

Source sequence(s)

AC117515, AC117516, AC126467, AC133040

Consensus CDS

CCDS93315.1

UniProtKB/TrEMBL

H7C4U9

Related

ENSP00000418190.2, ENST00000471893.2

Conserved Domains (6) summary

cd00063
Location:542 → 635

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:152 → 155

Ig; Ig strand A [structural motif]

cd05726
Location:335 → 432

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:47 → 145

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:439 → 525

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:152 → 237

Ig; Immunoglobulin domain
NM_001378197.1 → NP_001365126.1 roundabout homolog 2 isoform 13 precursor

Status: REVIEWED

Source sequence(s)

AC117515, AC117516, AC133040

Consensus CDS

CCDS93320.1

UniProtKB/TrEMBL

A0A994J7I9

Related

ENSP00000516193.1, ENST00000705983.1

Conserved Domains (6) summary

cd00063
Location:522 → 615

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:136 → 139

Ig; Ig strand A [structural motif]

cd05726
Location:315 → 412

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:31 → 129

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:419 → 505

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:136 → 221

Ig; Immunoglobulin domain
NM_001378198.1 → NP_001365127.1 roundabout homolog 2 isoform 14 precursor

Status: REVIEWED

Source sequence(s)

AC067717, AC117515, AC117516, AC133040

Conserved Domains (6) summary

cd00063
Location:549 → 642

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:159 → 162

Ig; Ig strand A [structural motif]

cd05726
Location:342 → 439

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:54 → 152

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:446 → 532

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:159 → 244

Ig; Immunoglobulin domain
NM_001378199.1 → NP_001365128.1 roundabout homolog 2 isoform 15 precursor

Status: REVIEWED

Source sequence(s)

AC067717, AC117515, AC117516, AC133040

Consensus CDS

CCDS93317.1

UniProtKB/TrEMBL

H7C4W9

Related

ENSP00000418446.2, ENST00000475334.2

Conserved Domains (6) summary

cd00063
Location:549 → 642

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:159 → 162

Ig; Ig strand A [structural motif]

cd05726
Location:342 → 439

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:54 → 152

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:446 → 532

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:159 → 244

Ig; Immunoglobulin domain
NM_001378200.1 → NP_001365129.1 roundabout homolog 2 isoform 16 precursor

Status: REVIEWED

Source sequence(s)

AC117515, AC117516, AC126467, AC133040

Conserved Domains (6) summary

cd00063
Location:542 → 635

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:152 → 155

Ig; Ig strand A [structural motif]

cd05726
Location:335 → 432

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:47 → 145

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:439 → 525

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:152 → 237

Ig; Immunoglobulin domain
NM_001378201.1 → NP_001365130.1 roundabout homolog 2 isoform 17 precursor

Status: REVIEWED

Source sequence(s)

AC117515, AC117516, AC126467, AC133040

Conserved Domains (6) summary

cd00063
Location:542 → 635

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:152 → 155

Ig; Ig strand A [structural motif]

cd05726
Location:335 → 432

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:47 → 145

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:439 → 525

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:152 → 237

Ig; Immunoglobulin domain
NM_001378202.1 → NP_001365131.1 roundabout homolog 2 isoform 18 precursor

Status: REVIEWED

Source sequence(s)

AC117515, AC117516, AC133040

Conserved Domains (6) summary

cd00063
Location:526 → 619

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:136 → 139

Ig; Ig strand A [structural motif]

cd05726
Location:319 → 416

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:31 → 129

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:423 → 509

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:136 → 221

Ig; Immunoglobulin domain
NM_001378203.1 → NP_001365132.1 roundabout homolog 2 isoform 19 precursor

Status: REVIEWED

Source sequence(s)

AC117515, AC117516, AC126467, AC133040

Conserved Domains (6) summary

cd00063
Location:542 → 635

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:152 → 155

Ig; Ig strand A [structural motif]

cd05726
Location:335 → 432

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:47 → 145

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:439 → 525

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:152 → 237

Ig; Immunoglobulin domain
NM_001394212.1 → NP_001381141.1 roundabout homolog 2 isoform 20 precursor

Status: REVIEWED

Source sequence(s)

AC067717, AC117515, AC117516, AC133040

Conserved Domains (6) summary

cd00063
Location:545 → 638

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:159 → 162

Ig; Ig strand A [structural motif]

cd05726
Location:338 → 435

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:54 → 152

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:442 → 528

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:159 → 244

Ig; Immunoglobulin domain
NM_001394213.1 → NP_001381142.1 roundabout homolog 2 isoform 21 precursor

Status: REVIEWED

Source sequence(s)

AC067717, AC117515, AC117516, AC133040

Conserved Domains (6) summary

cd00063
Location:549 → 642

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:159 → 162

Ig; Ig strand A [structural motif]

cd05726
Location:342 → 439

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:54 → 152

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:446 → 532

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:159 → 244

Ig; Immunoglobulin domain
NM_001394214.1 → NP_001381143.1 roundabout homolog 2 isoform 22 precursor

Status: REVIEWED

Source sequence(s)

AC067717, AC117515, AC117516, AC133040

Conserved Domains (6) summary

cd00063
Location:545 → 638

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:159 → 162

Ig; Ig strand A [structural motif]

cd05726
Location:338 → 435

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:54 → 152

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:442 → 528

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:159 → 244

Ig; Immunoglobulin domain
NM_001395656.1 → NP_001382585.1 roundabout homolog 2 isoform 23 precursor

Status: REVIEWED

Source sequence(s)

AC117515, AC117516, AC133040

Consensus CDS

CCDS93319.1

UniProtKB/TrEMBL

A0A8Q3WLE3

Related

ENSP00000512738.1, ENST00000696593.1

Conserved Domains (6) summary

cd00063
Location:526 → 619

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:136 → 139

Ig; Ig strand A [structural motif]

cd05726
Location:319 → 416

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:31 → 129

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:423 → 509

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:136 → 221

Ig; Immunoglobulin domain
NM_001395657.1 → NP_001382586.1 roundabout homolog 2 isoofrm 24 precursor

Status: REVIEWED

Source sequence(s)

AC067717, AC117515, AC117516, AC133040

Conserved Domains (2) summary

smart00409
Location:447 → 528

IG; Immunoglobulin

cd00063
Location:545 → 638

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_002942.5 → NP_002933.1 roundabout homolog 2 isoform ROBO2b precursor

See identical proteins and their annotated locations for NP_002933.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region compared to variant 4. The encoded protein (isoform ROBO2b; PMID 16829019) is shorter than variant 4.

Source sequence(s)

AC117515, AC133040, DQ533874

Consensus CDS

CCDS43109.1

UniProtKB/Swiss-Prot

O43608, Q19AB4, Q19AB5, Q9HCK4

Related

ENSP00000417164.1, ENST00000461745.5

Conserved Domains (5) summary

cd05726
Location:328 → 417

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:30 → 129

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

smart00409
Location:424 → 505

IG; Immunoglobulin

cd00063
Location:522 → 615

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:137 → 221

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

75906675..77649964

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047448673.1 → XP_047304629.1 roundabout homolog 2 isoform X11
XM_011533981.3 → XP_011532283.1 roundabout homolog 2 isoform X1

See identical proteins and their annotated locations for XP_011532283.1

Conserved Domains (6) summary

cd05726
Location:355 → 444

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:53 → 152

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

smart00409
Location:451 → 532

IG; Immunoglobulin

cd00063
Location:549 → 642

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam16599
Location:1374 → 1431

PTN13_u3; Unstructured linker region on PTN13 protein between PDZ

cl11960
Location:160 → 244

Ig; Immunoglobulin domain
XM_011533983.2 → XP_011532285.1 roundabout homolog 2 isoform X5

See identical proteins and their annotated locations for XP_011532285.1

Conserved Domains (6) summary

cd00063
Location:549 → 642

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:159 → 162

Ig; Ig strand A [structural motif]

cd05726
Location:342 → 439

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:54 → 152

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:446 → 532

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:159 → 244

Ig; Immunoglobulin domain
XM_017006988.2 → XP_016862477.1 roundabout homolog 2 isoform X6

Conserved Domains (6) summary

cd00063
Location:549 → 642

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:159 → 162

Ig; Ig strand A [structural motif]

cd05726
Location:342 → 439

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:54 → 152

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:446 → 532

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:159 → 244

Ig; Immunoglobulin domain
XM_017006994.2 → XP_016862483.1 roundabout homolog 2 isoform X12
XM_011533982.2 → XP_011532284.1 roundabout homolog 2 isoform X3

See identical proteins and their annotated locations for XP_011532284.1

Conserved Domains (7) summary

cd00096
Location:462 → 529

Ig; Immunoglobulin domain

cd05726
Location:355 → 444

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:53 → 152

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

smart00410
Location:451 → 532

IG_like; Immunoglobulin like

cd00063
Location:549 → 642

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:248 → 333

I-set; Immunoglobulin I-set domain

cl11960
Location:160 → 244

Ig; Immunoglobulin domain
XM_047448672.1 → XP_047304628.1 roundabout homolog 2 isoform X10
XM_047448674.1 → XP_047304630.1 roundabout homolog 2 isoform X13
XM_017006987.2 → XP_016862476.1 roundabout homolog 2 isoform X4
XM_047448671.1 → XP_047304627.1 roundabout homolog 2 isoform X9
XM_017007002.2 → XP_016862491.1 roundabout homolog 2 isoform X15
XM_047448676.1 → XP_047304632.1 roundabout homolog 2 isoform X14
XM_047448677.1 → XP_047304633.1 roundabout homolog 2 isoform X16
XM_017006986.2 → XP_016862475.1 roundabout homolog 2 isoform X2

Conserved Domains (7) summary

cd00096
Location:439 → 506

Ig; Immunoglobulin domain

cd05726
Location:332 → 421

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:30 → 129

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

smart00410
Location:428 → 509

IG_like; Immunoglobulin like

cd00063
Location:526 → 619

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:225 → 310

I-set; Immunoglobulin I-set domain

cl11960
Location:137 → 221

Ig; Immunoglobulin domain
XM_047448670.1 → XP_047304626.1 roundabout homolog 2 isoform X8
XM_047448669.1 → XP_047304625.1 roundabout homolog 2 isoform X7
XM_047448678.1 → XP_047304634.1 roundabout homolog 2 isoform X17