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NAA35 N-alpha-acetyltransferase 35, NatC auxiliary subunit [ Homo sapiens (human) ]

Gene ID: 60560, updated on 7-Apr-2024

Summary

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Official Symbol
NAA35provided by HGNC
Official Full Name
N-alpha-acetyltransferase 35, NatC auxiliary subunitprovided by HGNC
Primary source
HGNC:HGNC:24340
See related
Ensembl:ENSG00000135040 MIM:619438; AllianceGenome:HGNC:24340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EGAP; MAK10; MAK10P; bA379P1.1
Summary
Involved in negative regulation of apoptotic process. Located in cytosol; nucleoplasm; and plasma membrane. Part of NatC complex. Colocalizes with polysome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 7.0), colon (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
9q21.33
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (85941146..86025462)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (98091659..98175989)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (88556061..88640377)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:88513172-88514371 Neighboring gene PHB1 pseudogene 7 Neighboring gene ribosomal L1 domain-containing protein 1-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19991 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88650825-88651760 Neighboring gene golgi membrane protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88677599-88678515 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88679748-88680248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88680249-88681249 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:88693798-88694997 Neighboring gene Sharpr-MPRA regulatory region 3020 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:88713914-88714414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19994 Neighboring gene uncharacterized LOC101927623 Neighboring gene chromosome 4 open reading frame 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Evaluation of Salivary Exosomal Chimeric GOLM1-NAA35 RNA as a Potential Biomarker in Esophageal Carcinoma. Lin Y, et al. Clin Cancer Res, 2019 May 15. PMID 30745298
  2. Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi. Li Y, et al. Nat Med, 2016 Aug. PMID 27376574, Free PMC Article
  3. Aberrant chimeric RNA GOLM1-MAK10 encoding a secreted fusion protein as a molecular signature for human esophageal squamous cell carcinoma. Zhang H, et al. Oncotarget, 2013 Nov. PMID 24243830, Free PMC Article
  4. A novel epithelial wound-related gene is abundantly expressed in developing rat cornea and skin. Yi XJ, et al. Curr Eye Res, 2000 May. PMID 10855038
  5. Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. Starheim KK, et al. Mol Cell Biol, 2009 Jul. PMID 19398576, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. salivary exosomal GOLM1-NAA35 chimeric RNA (seG-NchiRNA) constitutes an effective candidate noninvasive biomarker for the convenient, reliable assessment of therapeutic response, recurrence, and early detection.
    Title: Evaluation of Salivary Exosomal Chimeric GOLM1-NAA35 RNA as a Potential Biomarker in Esophageal Carcinoma.
  2. A cytokine QTL at the NAA35-GOLM1 locus markedly modulated interleukin (IL)-6 production in response to multiple pathogens and was associated with susceptibility to candidemia.
    Title: Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi.
  3. Data demonstrate that chimera GOLM1-MAK10 encodes a secreted fusion protein. Mechanistic studies reveal that GOLM1-MAK10 is likely derived from transcription read-through/splicing rather than being generated from a fusion gene.
    Title: Aberrant chimeric RNA GOLM1-MAK10 encoding a secreted fusion protein as a molecular signature for human esophageal squamous cell carcinoma.
  4. Human Naa35 (MAK10) is an auxiliary subunit of the human NatC N-terminal acetyltransferase complex. NatC acetylates hydrophobic Met-starting N-termini, and NatC knockdown induces p53-dependent apoptosis.
    Title: Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21613, FLJ22643

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-terminal protein amino acid acetylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of NatC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NatC complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
N-alpha-acetyltransferase 35, NatC auxiliary subunit
Names
MAK10 homolog, amino-acid N-acetyltransferase subunit
corneal wound healing-related protein
embryonic growth-associated protein homolog
protein MAK10 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321881.2 → NP_001308810.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit

    Status: VALIDATED

    Source sequence(s)
    AK026296, AK292239, AL161447, BC117429
    Consensus CDS
    CCDS6673.1
    UniProtKB/Swiss-Prot
    Q5VZE5, Q5VZE6, Q9H631, Q9H703
    UniProtKB/TrEMBL
    A8K874
    Conserved Domains (1) summary
    pfam04112
    Location:46 → 181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

  2. NM_001321882.2 → NP_001308811.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit

    Status: VALIDATED

    Source sequence(s)
    AL161447, AL161453, AL353743
    Consensus CDS
    CCDS6673.1
    UniProtKB/Swiss-Prot
    Q5VZE5, Q5VZE6, Q9H631, Q9H703
    UniProtKB/TrEMBL
    A8K874
    Conserved Domains (1) summary
    pfam04112
    Location:46 → 181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

  3. NM_024635.4 → NP_078911.3  N-alpha-acetyltransferase 35, NatC auxiliary subunit

    See identical proteins and their annotated locations for NP_078911.3

    Status: VALIDATED

    Source sequence(s)
    AL161447, BC117427, CA945233, DB023442
    Consensus CDS
    CCDS6673.1
    UniProtKB/Swiss-Prot
    Q5VZE5, Q5VZE6, Q9H631, Q9H703
    UniProtKB/TrEMBL
    A8K874
    Related
    ENSP00000354972.5, ENST00000361671.10
    Conserved Domains (1) summary
    pfam04112
    Location:46 → 181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    85941146..86025462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252127.5 → XP_005252184.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X1

    See identical proteins and their annotated locations for XP_005252184.1

    UniProtKB/Swiss-Prot
    Q5VZE5, Q5VZE6, Q9H631, Q9H703
    UniProtKB/TrEMBL
    A8K874
    Conserved Domains (1) summary
    pfam04112
    Location:46 → 181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

  2. XM_047423710.1 → XP_047279666.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X2

  3. XM_024447648.2 → XP_024303416.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X3

  4. XM_024447649.2 → XP_024303417.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    98091659..98175989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363503.1 → XP_054219478.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X1

    UniProtKB/Swiss-Prot
    Q5VZE5, Q5VZE6, Q9H631, Q9H703

  2. XM_054363504.1 → XP_054219479.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X2

  3. XM_054363505.1 → XP_054219480.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X3

  4. XM_054363506.1 → XP_054219481.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_021929.1: Suppressed sequence

    Description
    NM_021929.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VZE5.1 GenPept UniProtKB/Swiss-Prot:Q5VZE5

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