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RNR2 RNA, ribosomal 45S cluster 2 [ Homo sapiens (human) ]

Gene ID: 6053, updated on 24-Mar-2019

Summary

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Official Symbol
RNR2provided by HGNC
Official Full Name
RNA, ribosomal 45S cluster 2provided by HGNC
Primary source
HGNC:HGNC:10083
See related
MIM:180451
Gene type
other
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
45S ribosomal DNA (rDNA) arrays, or clusters, are present on human chromosomes 13, 14, 15, 21 and 22, designated RNR1 through RNR5, respectively. Each cluster consists of multiple 45S rDNA repeat units that vary in number among individuals and chromosomes, with total diploid copy number estimates ranging from 60 to >800 repeat units in a human genome. The 45S rDNA repeat unit encodes a 45S rRNA precursor, transcribed by RNA polymerase I, which is processed to form the 18S, 5.8S and 28S rRNAs. Gene and RefSeq, in collaboration with HGNC, currently describe one 45S rDNA cluster, and one set of 45S precursor and product rRNAs, for each of the five human chromosomes to which these loci are localized. This gene represents the 45S ribosomal DNA cluster on chromosome 14. [provided by RefSeq, Feb 2017]
Annotation information
not in current annotation release
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Genomic context

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Location:
14p12

Bibliography

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Related articles in PubMed

  1. Human rDNA: evolutionary patterns within the genes and tandem arrays derived from multiple chromosomes. Gonzalez IL, et al. Genomics, 2001 May 1. PMID 11350117
  2. A Portrait of Ribosomal DNA Contacts with Hi-C Reveals 5S and 45S rDNA Anchoring Points in the Folded Human Genome. Yu S, et al. Genome Biol Evol, 2016 Dec 31. PMID 27797956, Free PMC Article
  3. Nucleolar organizer regions: genomic 'dark matter' requiring illumination. McStay B. Genes Dev, 2016 Jul 15. PMID 27474438, Free PMC Article
  4. The Epigenetic Pathways to Ribosomal DNA Silencing. Srivastava R, et al. Microbiol Mol Biol Rev, 2016 Sep. PMID 27250769, Free PMC Article
  5. Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomes. Gibbons JG, et al. Proc Natl Acad Sci U S A, 2015 Feb 24. PMID 25583482, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Other Names

  • 45S rDNA cluster 2
  • RNA, ribosomal 2
  • RNA, ribosomal cluster 2
  • Ribosomal RNA-2

NCBI Reference Sequences (RefSeq)

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Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_024197.1: Suppressed sequence

    Description
    NR_024197.1: This RefSeq was permanently suppressed because it represented sequence which was not part of a rRNA encoding repeat.
Nucleotide Protein
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