NPS neuropeptide S [Homo sapiens (human)] - Gene

Summary

Official Symbol: NPSprovided by HGNC
Official Full Name: neuropeptide Sprovided by HGNC
Primary source: HGNC:HGNC:33940
See related: Ensembl:ENSG00000214285 MIM:609513; AllianceGenome:HGNC:33940
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to be involved in positive regulation of GABAergic synaptic transmission; positive regulation of action potential; and positive regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within visual learning. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: mouse all
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Genomic context

Location:: 10q26.2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (127549309..127553540)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (128444335..128448567)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (129347573..129351804)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neandertal introgression and accumulation of hypomorphic mutations in the neuropeptide S (NPS) system promote attenuated functionality.
Title: Neandertal introgression and accumulation of hypomorphic mutations in the neuropeptide S (NPS) system promote attenuated functionality.
Further refining the critical region of 10q26 microdeletion syndrome: A possible involvement of INSYN2 and NPS in the cognitive phenotype.
Title: Further refining the critical region of 10q26 microdeletion syndrome: A possible involvement of INSYN2 and NPS in the cognitive phenotype.
analgesic effects of NPS are linked with dopaminergic neurotransmission mainly through dopamine D2-like receptor signaling
Title: Dopamine D(1) and D(2) receptors mediate neuropeptide S-induced antinociception in the mouse formalin test.
SNPs modify asthma risk
Title: Neuropeptide S (NPS) variants modify the signaling and risk effects of NPS Receptor 1 (NPSR1) variants in asthma.
A SNP within the neuropeptide s gene is associated with decreased bioactivity.
Title: A single-nucleotide polymorphism of human neuropeptide s gene originated from Europe shows decreased bioactivity.
NPS is able to stimulate human monocyte chemotaxis and that this effect is entirely due to selective NPSR activation.
Title: Neuropeptide S stimulates human monocyte chemotaxis via NPS receptor activation.
The available information regarding NPS and its receptor and the biological actions modulated by the NPS-NPSR system, is summarized.
Title: Neurobiology, pharmacology, and medicinal chemistry of neuropeptide S and its receptor.
NPS-NPSR1 signaling is likely involved in anxiety
Title: Assessment of the neuropeptide S system in anxiety disorders.
Observational study of gene-disease association. (HuGE Navigator)
Title: Assessment of the neuropeptide S system in anxiety disorders.
NPS acts as a novel modulator of arousal and anxiety-related behaviours by promoting a unique pattern of effects: stimulation associated with anxiolysis.
Title: Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of circadian sleep/wake cycle, wakefulness	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission, GABAergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in visual learning	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuropeptide S

Names: prepro-neuropeptide S

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.