U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RANBP1 RAN binding protein 1 [ Homo sapiens (human) ]

Gene ID: 5902, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
RANBP1provided by HGNC
Official Full Name
RAN binding protein 1provided by HGNC
Primary source
HGNC:HGNC:9847
See related
Ensembl:ENSG00000099901 MIM:601180; AllianceGenome:HGNC:9847
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HTF9A
Summary
This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in testis (RPKM 15.4), lymph node (RPKM 10.2) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RANBP1 in Genome Data Viewer
Location:
22q11.21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (20116104..20127355)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (20495154..20506390)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20103627..20114878)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene DGCR8 microprocessor complex subunit Neighboring gene microRNA 1306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20099501-20100000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13475 Neighboring gene tRNA methyltransferase 2 homolog A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13476 Neighboring gene microRNA 6816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18671 Neighboring gene small nucleolar RNA, H/ACA box 77B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13477 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13478 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20119547-20120200 Neighboring gene zinc finger DHHC-type palmitoyltransferase 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20125107-20125706 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13482 Neighboring gene coiled-coil domain containing 188

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma. Kahm YJ, et al. Int J Mol Sci, 2023 Apr 6. PMID 37047826, Free PMC Article
  2. Association of RANBP1 haplotype with smooth pursuit eye movement abnormality. Cheong HS, et al. Am J Med Genet B Neuropsychiatr Genet, 2011 Jan. PMID 21184585
  3. RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells. Tedeschi A, et al. J Cell Sci, 2007 Nov 1. PMID 17940066
  4. The Ran GTPase regulates kinetochore function. Arnaoutov A, et al. Dev Cell, 2003 Jul. PMID 12852855
  5. Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation. Görlich D, et al. EMBO J, 2003 Mar 3. PMID 12606574, Free PMC Article

See all (132) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oxidative stress and signaling through EGFR and PKA pathways converge on the nuclear transport factor RanBP1.
    Title: Oxidative stress and signaling through EGFR and PKA pathways converge on the nuclear transport factor RanBP1.
  2. RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma.
    Title: RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma.
  3. RanBP1 controls the Ran pathway in mammalian cells through regulation of mitotic RCC1 dynamics.
    Title: RanBP1 controls the Ran pathway in mammalian cells through regulation of mitotic RCC1 dynamics.
  4. Sgk1-dependent regulation of RANBP1 has functional consequences on both mitotic microtubule activity and taxol sensitivity of cancer cells.
    Title: Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells.
  5. in vitro and in vivo phosphorylation of RanBP1 by Plk1 as well as the importance of phosphorylation of RanBP1 in the interaction between Plk1 and Ran during early mitosis, is demonstrated.
    Title: Phosphorylation of Ran-binding protein-1 by Polo-like kinase-1 is required for interaction with Ran and early mitotic progression.
  6. RANBP1 on 22q11.21 locus might be causally related to the smooth pursuit eye movement abnormality rather than the development of schizophrenia.
    Title: Association of RANBP1 haplotype with smooth pursuit eye movement abnormality.
  7. Downregulation of the Ran GTPase effector RanBP1 is required for nuclear reorganisation.
    Title: Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
  9. Generation of Ran-GTP from Ran-GDP by importin-beta is activated by Ran-binding protein-1 (RanBP1) that forms a trimeric complex with Ran-GDP and importin-beta.
    Title: Importin-beta is a GDP-to-GTP exchange factor of Ran: implications for the mechanism of nuclear import.
  10. RanBP1-interfered cells show an increased apoptotic response to taxol compared to their counterpart with normal or high RanBP1 levels, and this response is caspase-3 dependent.
    Title: RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction Pubs
Knockdown of RAN binding protein 1 (RANBP1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev RanBP1 competes with Rev for the same nuclear export pathway and as a result can affect Rev-mediated nuclear export of HIV-1 mRNA PubMed
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with RAN binding protein 1 (RANBP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ37091, FLJ54173, MGC88701

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GDP-dissociation inhibitor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of mitotic centrosome separation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nuclear envelope TAS
Traceable Author Statement
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
ran-specific GTPase-activating protein
Names
HpaII tiny fragments locus 9A
testis secretory sperm-binding protein Li 221n

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278639.2 → NP_001265568.1  ran-specific GTPase-activating protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AW404614, CA489474, DC397929, HY229989, X83617
    Consensus CDS
    CCDS74823.1
    UniProtKB/TrEMBL
    F6WQW2
    Related
    ENSP00000401564.2, ENST00000430524.6
    Conserved Domains (1) summary
    cd13179
    Location:101 → 237
    RanBD_RanBP1; Ran-binding domain

  2. NM_001278640.2 → NP_001265569.1  ran-specific GTPase-activating protein isoform 3

    See identical proteins and their annotated locations for NP_001265569.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains multiple differences, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AW404614, D38076, HY229989
    Consensus CDS
    CCDS63408.1
    UniProtKB/Swiss-Prot
    P43487
    Related
    ENSP00000384925.1, ENST00000402752.5
    Conserved Domains (1) summary
    cd13179
    Location:24 → 160
    RanBD_RanBP1; Ran-binding domain

  3. NM_001278641.2 → NP_001265570.1  ran-specific GTPase-activating protein isoform 4

    See identical proteins and their annotated locations for NP_001265570.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains multiple differences, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC006547, AW404614, BG717186, BI916757, HY229989
    UniProtKB/TrEMBL
    C9JXG8
    Related
    ENSP00000413502.2, ENST00000418705.2
    Conserved Domains (1) summary
    cd13179
    Location:1 → 110
    RanBD_RanBP1; Ran-binding domain

  4. NM_002882.4 → NP_002873.1  ran-specific GTPase-activating protein isoform 2

    See identical proteins and their annotated locations for NP_002873.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AW404614, DB459798, HY229989, X83617
    Consensus CDS
    CCDS13775.1
    UniProtKB/Swiss-Prot
    P43487, Q53EY3
    UniProtKB/TrEMBL
    A0A140VK94
    Related
    ENSP00000327583.3, ENST00000331821.8
    Conserved Domains (1) summary
    cd13179
    Location:24 → 160
    RanBD_RanBP1; Ran-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    20116104..20127355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530289.4 → XP_011528591.1  ran-specific GTPase-activating protein isoform X1

    See identical proteins and their annotated locations for XP_011528591.1

    UniProtKB/TrEMBL
    B4DE76, B7Z6U1
    Conserved Domains (1) summary
    cd13179
    Location:24 → 146
    RanBD_RanBP1; Ran-binding domain

  2. XM_017028892.2 → XP_016884381.1  ran-specific GTPase-activating protein isoform X3

    UniProtKB/TrEMBL
    C9JXG8
    Conserved Domains (1) summary
    cd13179
    Location:1 → 110
    RanBD_RanBP1; Ran-binding domain

  3. XM_011530290.3 → XP_011528592.1  ran-specific GTPase-activating protein isoform X2

    See identical proteins and their annotated locations for XP_011528592.1

    UniProtKB/TrEMBL
    B3KUP2
    Conserved Domains (1) summary
    cl17171
    Location:14 → 70
    PH-like; Pleckstrin homology-like domain

  4. XM_047441451.1 → XP_047297407.1  ran-specific GTPase-activating protein isoform X5

  5. XM_047441450.1 → XP_047297406.1  ran-specific GTPase-activating protein isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    20495154..20506390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325804.1 → XP_054181779.1  ran-specific GTPase-activating protein isoform X1

    UniProtKB/TrEMBL
    B4DE76

  2. XM_054325806.1 → XP_054181781.1  ran-specific GTPase-activating protein isoform X3

  3. XM_054325805.1 → XP_054181780.1  ran-specific GTPase-activating protein isoform X2

    UniProtKB/TrEMBL
    B3KUP2

  4. XM_054325808.1 → XP_054181783.1  ran-specific GTPase-activating protein isoform X5

  5. XM_054325807.1 → XP_054181782.1  ran-specific GTPase-activating protein isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43487.1 GenPept UniProtKB/Swiss-Prot:P43487

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous