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RAD51B RAD51 paralog B [ Homo sapiens (human) ]

Gene ID: 5890, updated on 10-Mar-2024

Summary

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Official Symbol
RAD51Bprovided by HGNC
Official Full Name
RAD51 paralog Bprovided by HGNC
Primary source
HGNC:HGNC:9822
See related
Ensembl:ENSG00000182185 MIM:602948; AllianceGenome:HGNC:9822
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
REC2; R51H2; RAD51L1
Summary
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
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Genomic context

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See RAD51B in Genome Data Viewer
Location:
14q24.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (67819779..68683096)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (62026883..62889971)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (68286496..69149813)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 213, pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member C9 pseudogene Neighboring gene zinc finger FYVE-type containing 26 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8587 Neighboring gene Sharpr-MPRA regulatory region 13811 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:68286883-68287644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:68335343-68335842 Neighboring gene MPRA-validated peak2182 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:68395137-68396136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:68552975-68553525 Neighboring gene centrosomal protein 170kDa pseudogene Neighboring gene uncharacterized LOC105370546 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:68604367-68605351 Neighboring gene VISTA enhancer hs1392 Neighboring gene RNA, 7SL, cytoplasmic 706, pseudogene Neighboring gene Sharpr-MPRA regulatory region 3110 Neighboring gene MPRA-validated peak2183 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8590 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:68698864-68700063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8595 Neighboring gene RNA, 7SL, cytoplasmic 108, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8596 Neighboring gene Sharpr-MPRA regulatory region 2611 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8599 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8600 Neighboring gene Sharpr-MPRA regulatory region 10624 Neighboring gene Sharpr-MPRA regulatory region 2571 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8606 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:68810048-68810732 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5867 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:68830720-68831247 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:68831248-68831776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8607 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:68838900-68839755 Neighboring gene VISTA enhancer hs1688 Neighboring gene uncharacterized LOC101927971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:68863880-68864606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8608 Neighboring gene ribosomal protein L7a pseudogene 5 Neighboring gene Sharpr-MPRA regulatory region 3354 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:68937409-68937942 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:68937943-68938476 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:68942861-68944060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:68972115-68972678 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:68972679-68973242 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:68973243-68973806 Neighboring gene peptidylprolyl isomerase A pseudogene 6 Neighboring gene VISTA enhancer hs1616 Neighboring gene uncharacterized LOC124903334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:68993143-68993664 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:68993665-68994185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69006151-69006711 Neighboring gene RAD51B intron CAGE-defined mid-level expression enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69017510-69018030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69018031-69018551 Neighboring gene uncharacterized LOC124903335 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:69035996-69036508 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69052085-69052586 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36364 Neighboring gene uncharacterized LOC107984016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69073752-69074398 Neighboring gene Sharpr-MPRA regulatory region 11310 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:69086033-69086224 Neighboring gene uncharacterized LOC100996664 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5868 Neighboring gene uncharacterized LOC124903333 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:69124801-69124929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8611 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69136655-69137155 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69136154-69136654 Neighboring gene Sharpr-MPRA regulatory region 15027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69143042-69143542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69143543-69144043 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:69149771-69150316 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:69150317-69150861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69171588-69172111 Neighboring gene uncharacterized LOC105370547 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69197453-69198006 Neighboring gene RNA, U6 small nuclear 921, pseudogene Neighboring gene ribosomal protein L12 pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RAD51B Harbors Germline Mutations Associated With Pancreatic Ductal Adenocarcinoma. Xie F, et al. JCO Precis Oncol, 2022 Jun. PMID 35737913, Free PMC Article
  2. Polymorphisms of RAD51B are associated with rheumatoid arthritis and erosion in rheumatoid arthritis patients. Zhi L, et al. Sci Rep, 2017 Mar 31. PMID 28361912, Free PMC Article
  3. RAD51B as a potential biomarker for early detection and poor prognostic evaluation contributes to tumorigenesis of gastric cancer. Cheng Y, et al. Tumour Biol, 2016 Nov. PMID 27651161
  4. Genetic variants within microRNA-binding site of RAD51B are associated with risk of cervical cancer in Chinese women. Hang D, et al. Cancer Med, 2016 Sep. PMID 27334422, Free PMC Article
  5. RAD51B in Familial Breast Cancer. Pelttari LM, et al. PLoS One, 2016. PMID 27149063, Free PMC Article

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sarcomas With RAD51B Fusions Are Associated With a Heterogeneous Phenotype.
    Title: Sarcomas With RAD51B Fusions Are Associated With a Heterogeneous Phenotype.
  2. Structural insights into BCDX2 complex function in homologous recombination.
    Title: Structural insights into BCDX2 complex function in homologous recombination.
  3. Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor.
    Title: Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor.
  4. RAD51B Harbors Germline Mutations Associated With Pancreatic Ductal Adenocarcinoma.
    Title: RAD51B Harbors Germline Mutations Associated With Pancreatic Ductal Adenocarcinoma.
  5. Serum Levels of ARMS2, COL8A1, RAD51B, and VEGF and their Correlations in Age-related Macular Degeneration.
    Title: Serum Levels of ARMS2, COL8A1, RAD51B, and VEGF and their Correlations in Age-related Macular Degeneration.
  6. TBX15 rs98422, DNM3 rs1011731, RAD51B rs8017304, and rs2588809 Gene Polymorphisms and Associations With Pituitary Adenoma.
    Title: TBX15 rs98422, DNM3 rs1011731, RAD51B rs8017304, and rs2588809 Gene Polymorphisms and Associations With Pituitary Adenoma.
  7. Sequential role of RAD51 paralog complexes in replication fork remodeling and restart.
    Title: Sequential role of RAD51 paralog complexes in replication fork remodeling and restart.
  8. Here we provide three coherent sets of isogenic mutants, both in transformed and non-transformed human cells. Importantly, using these mutant lines, we report the unanticipated result that RAD51B has a less crucial role in homologous recombination than the other four paralogs, and find that all RAD51 paralogs are critically important for early functions during homologous recombination
    Title: Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells.
  9. We successfully identified a common variant, rs911263, as being significantly associated with the disease status . In addition, this SNP was shown to be related to erosion, a clinical assessment of disease severity in RA (P = 2.89 x 10(-5), OR = 0.52). These findings shed light on the role of RAD51B in the onset and severity of Rheumatoid arthritis (RA).
    Title: Polymorphisms of RAD51B are associated with rheumatoid arthritis and erosion in rheumatoid arthritis patients.
  10. hypermethylation of homologous recombination DNA repair genes including RAD51B and XRCC3 is associated with an inflamed phenotype in squamous cell cancers of the head and neck, lung and cervix.
    Title: Methylation of RAD51B, XRCC3 and other homologous recombination genes is associated with expression of immune checkpoints and an inflammatory signature in squamous cell carcinoma of the head and neck, lung and cervix.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide scan for breast cancer risk haplotypes among African American women.
EBI GWAS Catalog
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
EBI GWAS Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
EBI GWAS Catalog
Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
EBI GWAS Catalog
Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.
EBI GWAS Catalog
Genome-wide association study reveals multiple loci associated with primary tooth development during infancy.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
EBI GWAS Catalog
New gene functions in megakaryopoiesis and platelet formation.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Novel genetic markers of breast cancer survival identified by a genome-wide association study.
EBI GWAS Catalog
Seven new loci associated with age-related macular degeneration.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC34245

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent activity, acting on DNA IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to four-way junction DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to four-way junction DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA recombination TAS
Traceable Author Statement
more info
 PubMed 
involved_in DNA repair TAS
Traceable Author Statement
more info
 PubMed 
involved_in blastocyst growth IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in reciprocal meiotic recombination TAS
Traceable Author Statement
more info
 PubMed 
involved_in somite development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
is_active_in replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in replication fork IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA repair protein RAD51 homolog 2
Names
RAD51 homolog B
RecA-like protein
recombination repair protein

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023267.2 RefSeqGene

    Range
    5001..663315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321809.2 → NP_001308738.1  DNA repair protein RAD51 homolog 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL121595, AL121820, AL122013, AL589168
    Conserved Domains (2) summary
    cd01123
    Location:83 → 343
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam08423
    Location:65 → 342
    Rad51; Rad51

  2. NM_001321810.2 → NP_001308739.1  DNA repair protein RAD51 homolog 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL121595, AL121820, AL122013, AL589168
    Conserved Domains (2) summary
    cd01123
    Location:83 → 343
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam08423
    Location:65 → 342
    Rad51; Rad51

  3. NM_001321812.1 → NP_001308741.1  DNA repair protein RAD51 homolog 2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL121595, AL122013, AL589168
    Conserved Domains (2) summary
    cd01123
    Location:83 → 343
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam08423
    Location:65 → 342
    Rad51; Rad51

  4. NM_001321814.2 → NP_001308743.1  DNA repair protein RAD51 homolog 2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL121595, AL122013, AL589168
    Conserved Domains (2) summary
    cd01123
    Location:83 → 343
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam08423
    Location:65 → 342
    Rad51; Rad51

  5. NM_001321815.1 → NP_001308744.1  DNA repair protein RAD51 homolog 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL121595, AL121820, AL122013, AL589168
    Conserved Domains (2) summary
    cd01123
    Location:45 → 305
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam08423
    Location:27 → 304
    Rad51; Rad51

  6. NM_001321817.2 → NP_001308746.1  DNA repair protein RAD51 homolog 2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL121595, AL589168, BX161515
    UniProtKB/Swiss-Prot
    O15315
    Conserved Domains (1) summary
    cd01123
    Location:1 → 224
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

  7. NM_001321818.2 → NP_001308747.1  DNA repair protein RAD51 homolog 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL121595, AL121820, AL122013, AL589168
    Related
    ENSP00000420061.1, ENST00000488612.5
    Conserved Domains (1) summary
    cd19493
    Location:91 → 327
    Rad51B; RAD51B recombinase

  8. NM_001321819.1 → NP_001308748.1  DNA repair protein RAD51 homolog 2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL121595, AL122013, AL589168
    Conserved Domains (2) summary
    cd01123
    Location:83 → 343
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam08423
    Location:65 → 342
    Rad51; Rad51

  9. NM_001321821.2 → NP_001308750.1  DNA repair protein RAD51 homolog 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AK309787, AK310686, AL121820
    Consensus CDS
    CCDS81815.1
    UniProtKB/TrEMBL
    C9JYJ0
    Related
    ENSP00000419881.1, ENST00000487861.5
    Conserved Domains (2) summary
    cd01123
    Location:83 → 343
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam08423
    Location:65 → 342
    Rad51; Rad51

  10. NM_002877.6 → NP_002868.1  DNA repair protein RAD51 homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_002868.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate exon at the 3' end compared to the longest variant (3). The resulting isoform (1) has a distinct C-terminus, as compared to isoform 3.
    Source sequence(s)
    AL597484, BM671299, CB051081, U84138, U92074
    Related
    ENSP00000518559.1, ENST00000460526.6
    Conserved Domains (1) summary
    cd19493
    Location:91 → 327
    Rad51B; RAD51B recombinase

  11. NM_133509.5 → NP_598193.2  DNA repair protein RAD51 homolog 2 isoform 3

    See identical proteins and their annotated locations for NP_598193.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. It encodes the isoform (3) that has a distinct C-terminus, compared to isoform 1 and 2.
    Source sequence(s)
    AL121820, AL597484, BC030219, BQ101024, BX248766, CK823089
    Consensus CDS
    CCDS9789.1
    UniProtKB/Swiss-Prot
    O15315, O60914, O75210, Q3Y4F8, Q6FHX8, Q86SY3, Q86SY4, Q86TR0, Q86U92, Q86U93, Q86U94, Q8N6H4, Q9UPL5
    Related
    ENSP00000419471.1, ENST00000487270.5
    Conserved Domains (1) summary
    cd01123
    Location:83 → 343
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

  12. NM_133510.4 → NP_598194.1  DNA repair protein RAD51 homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_598194.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate exon at the 3' end compared to the longest variant (3). The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 3.
    Source sequence(s)
    AL597484, BX161515, Y15571
    Consensus CDS
    CCDS9790.1
    UniProtKB/Swiss-Prot
    O15315
    Related
    ENSP00000418859.1, ENST00000471583.6
    Conserved Domains (2) summary
    cd01123
    Location:83 → 343
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam08423
    Location:65 → 342
    Rad51; Rad51

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    67819779..68683096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    62026883..62889971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15315.2 GenPept UniProtKB/Swiss-Prot:O15315

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