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RAB1A RAB1A, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 5861, updated on 11-Apr-2024

Summary

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Official Symbol
RAB1Aprovided by HGNC
Official Full Name
RAB1A, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9758
See related
Ensembl:ENSG00000138069 MIM:179508; AllianceGenome:HGNC:9758
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAB1; YPT1
Summary
This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in kidney (RPKM 68.0), thyroid (RPKM 58.5) and 25 other tissues See more
Orthologs
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Genomic context

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See RAB1A in Genome Data Viewer
Location:
2p14
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (65086854..65130106, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (65096482..65139769, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (65313988..65357240, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 548, pseudogene Neighboring gene solute carrier family 1 member 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15923 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:65258211-65259074 Neighboring gene long intergenic non-protein coding RNA 2576 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15924 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:65277603-65277775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11573 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11575 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:65288315-65288816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:65294702-65295470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:65295471-65296237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:65297006-65297772 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:65304333-65305043 Neighboring gene centrosomal protein 68 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:65354445-65354984 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:65356508-65357022 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:65357023-65357536 Neighboring gene small nucleolar RNA SNORA74 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:65404421-65404957 Neighboring gene MPRA-validated peak3732 silencer Neighboring gene uncharacterized LOC124907779 Neighboring gene VDAC2 pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Rab1A promotes cell proliferation and migration by upregulating Gli1 in colorectal cancer. Peng C, et al. Sci Rep, 2021 Aug 10. PMID 34376787, Free PMC Article
  2. RAB1A regulates glioma cellular proliferation and invasion via the mTOR signaling pathway and epithelial-mesenchymal transition. Ren B, et al. Future Oncol, 2021 Aug. PMID 33947216
  3. Pooled analysis of prognostic value and clinical significance of Rab1A expression in human solid tumors. Shao X, et al. Medicine (Baltimore), 2019 Dec. PMID 31852145, Free PMC Article
  4. Expression analysis and implication of Rab1A in gastrointestinal relevant tumor. Xu M, et al. Sci Rep, 2019 Sep 16. PMID 31527621, Free PMC Article
  5. Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer. Cheng Z, et al. Oncol Rep, 2019 May. PMID 30896866, Free PMC Article

See all (202) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deubiquitinating enzyme PSMD7 promotes bladder cancer development: Involvement of RAB1A stabilization.
    Title: Deubiquitinating enzyme PSMD7 promotes bladder cancer development: Involvement of RAB1A stabilization.
  2. RAB1A haploinsufficiency phenocopies the 2p14-p15 microdeletion and is associated with impaired neuronal differentiation.
    Title: RAB1A haploinsufficiency phenocopies the 2p14-p15 microdeletion and is associated with impaired neuronal differentiation.
  3. Prognosis value and positive association of Rab1A/IL4Ralpha aberrant expression in gastric cancer.
    Title: Prognosis value and positive association of Rab1A/IL4Rα aberrant expression in gastric cancer.
  4. Subcellular Distribution of BALF2 and the Role of Rab1 in the Formation of Epstein-Barr Virus Cytoplasmic Assembly Compartment and Virion Release.
    Title: Subcellular Distribution of BALF2 and the Role of Rab1 in the Formation of Epstein-Barr Virus Cytoplasmic Assembly Compartment and Virion Release.
  5. SGOL2 promotes prostate cancer progression by inhibiting RAB1A ubiquitination.
    Title: SGOL2 promotes prostate cancer progression by inhibiting RAB1A ubiquitination.
  6. Circ_0061140 Contributes to the Malignant Progression in Ovarian Cancer Cells by Mediating the RAB1A Level Through Sponging miR-361-5p.
    Title: Circ_0061140 Contributes to the Malignant Progression in Ovarian Cancer Cells by Mediating the RAB1A Level Through Sponging miR-361-5p.
  7. Circ_0026123 promotes cisplatin resistance and progression of ovarian cancer by upregulating RAB1A through sequestering miR-543.
    Title: Circ_0026123 promotes cisplatin resistance and progression of ovarian cancer by upregulating RAB1A through sequestering miR-543.
  8. Differences in IFNbeta secretion upon Rab1 inactivation in cells exposed to distinct innate immune stimuli.
    Title: Differences in IFNβ secretion upon Rab1 inactivation in cells exposed to distinct innate immune stimuli.
  9. Rab1A promotes IL-4R/JAK1/STAT6-dependent metastasis and determines JAK1 inhibitor sensitivity in non-small cell lung cancer.
    Title: Rab1A promotes IL-4R/JAK1/STAT6-dependent metastasis and determines JAK1 inhibitor sensitivity in non-small cell lung cancer.
  10. RAB1A regulates glioma cellular proliferation and invasion via the mTOR signaling pathway and epithelial-mesenchymal transition.
    Title: RAB1A regulates glioma cellular proliferation and invasion via the mTOR signaling pathway and epithelial-mesenchymal transition.
Submit: New GeneRIF Correction See all GeneRIFs (66)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env Overexpression of TBC1D20, RAB1A, or RAB1B results in abnormal HIV-1 gp41 migration, suggesting that a precise regulation of the RAB1/TBC1D20 axis is necessary for proper HIV-1 gp41 processing PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp564B163

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in establishment of endothelial intestinal barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in growth hormone secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in melanosome transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of glycoprotein metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of interleukin-8 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle transport along microtubule IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in virion assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in virion assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
located_in transport vesicle membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
ras-related protein Rab-1A
Names
GTP binding protein Rab1a
RAB1, member RAS oncogene family
Rab GTPase YPT1 homolog
YPT1-related protein
NP_004152.1
NP_056358.1
XP_005264525.1
XP_054199224.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004161.5 → NP_004152.1  ras-related protein Rab-1A isoform 1

    See identical proteins and their annotated locations for NP_004152.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AI768809, AK055927, BC000905, DC352417
    Consensus CDS
    CCDS46306.1
    UniProtKB/Swiss-Prot
    P11476, P62820, Q6FIE7, Q96N61, Q9Y3T2
    UniProtKB/TrEMBL
    D6W5F3, Q5U0I6, Q6FIG4
    Related
    ENSP00000387286.3, ENST00000409784.8
    Conserved Domains (1) summary
    cd01869
    Location:10 → 175
    Rab1_Ypt1; Rab GTPase family 1 includes the yeast homolog Ypt1

  2. NM_015543.2 → NP_056358.1  ras-related protein Rab-1A isoform 2

    See identical proteins and their annotated locations for NP_056358.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate segments in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AI768809, AK055927, AL050268, DC352417
    Consensus CDS
    CCDS46305.1
    UniProtKB/Swiss-Prot
    P62820
    Related
    ENSP00000381540.3, ENST00000398529.7
    Conserved Domains (1) summary
    cl38936
    Location:10 → 99
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    65086854..65130106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264468.3 → XP_005264525.1  ras-related protein Rab-1A isoform X1

    See identical proteins and their annotated locations for XP_005264525.1

    UniProtKB/TrEMBL
    B7Z8M7, Q6FIG4
    Related
    ENSP00000386451.1, ENST00000409892.5
    Conserved Domains (1) summary
    cl38936
    Location:10 → 143
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    65096482..65139769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343249.1 → XP_054199224.1  ras-related protein Rab-1A isoform X1

    UniProtKB/TrEMBL
    B7Z8M7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62820.3 GenPept UniProtKB/Swiss-Prot:P62820

Gene LinkOut

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