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OSTC oligosaccharyltransferase complex non-catalytic subunit [ Homo sapiens (human) ]

Gene ID: 58505, updated on 5-Mar-2024

Summary

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Official Symbol
OSTCprovided by HGNC
Official Full Name
oligosaccharyltransferase complex non-catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:24448
See related
Ensembl:ENSG00000198856 MIM:619023; AllianceGenome:HGNC:24448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DC2
Summary
Predicted to contribute to dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 57.1), endometrium (RPKM 49.2) and 25 other tissues See more
Orthologs
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Genomic context

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See OSTC in Genome Data Viewer
Location:
4q25
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (108650599..108667820)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (111953502..111970777)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (109571755..109588976)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RPL34 divergent transcript Neighboring gene uncharacterized LOC101929621 Neighboring gene VISTA enhancer hs1050 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:109541270-109542469 Neighboring gene ribosomal protein L34 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:109574151-109574665 Neighboring gene RNA, U6 small nuclear 431, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:109634746-109635604 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:109635605-109636463 Neighboring gene ethanolamine-phosphate phospho-lyase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:109708719-109709219 Neighboring gene regulator of chromosome condensation 2 pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Oligosaccharyltransferase complex-congenital disorders of glycosylation: A novel congenital disorder of glycosylation. Bryant EM, et al. Am J Med Genet A, 2020 Jun. PMID 32267060
  2. Heat shock induces expression of OSTC/DC2, a novel subunit of oligosaccharyltransferase, in vitro and in vivo. Chen CM, et al. Kaohsiung J Med Sci, 2014 May. PMID 24751383
  3. DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase and the ER translocon. Shrimal S, et al. J Cell Biol, 2017 Nov 6. PMID 28860277, Free PMC Article
  4. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. Shibatani T, et al. Biochemistry, 2005 Apr 26. PMID 15835887
  5. Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. Ramírez AS, et al. Science, 2019 Dec 13. PMID 31831667

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oligosaccharyltransferase complex-congenital disorders of glycosylation: A novel congenital disorder of glycosylation.
    Title: Oligosaccharyltransferase complex-congenital disorders of glycosylation: A novel congenital disorder of glycosylation.
  2. DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase STT3A and the endoplasmic reticulum translocon.
    Title: DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase and the ER translocon.
  3. These results suggest that the upregulation of OSTC/DC2, a novel component of the oligosaccharyltransferase complex, is part of the mammalian heat shock response.
    Title: Heat shock induces expression of OSTC/DC2, a novel subunit of oligosaccharyltransferase, in vitro and in vivo.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity IC
Inferred by Curator
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein N-linked glycosylation via asparagine IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oligosaccharyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of oligosaccharyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
oligosaccharyltransferase complex subunit OSTC
Names
hydrophobic protein HSF-28
oligosaccharyltransferase complex subunit (non-catalytic)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267817.2 → NP_001254746.1  oligosaccharyltransferase complex subunit OSTC isoform 2

    See identical proteins and their annotated locations for NP_001254746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC107071, AF343342, BM994257, CB110420
    Consensus CDS
    CCDS75177.1
    UniProtKB/TrEMBL
    A0A087WUD3
    Related
    ENSP00000478564.1, ENST00000613215.4

  2. NM_001267818.2 → NP_001254747.1  oligosaccharyltransferase complex subunit OSTC isoform 3

    See identical proteins and their annotated locations for NP_001254747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC107071, AF343342, BM994257, CN430159
    Consensus CDS
    CCDS58921.1
    UniProtKB/Swiss-Prot
    Q9NRP0
    Related
    ENSP00000426167.2, ENST00000512478.2
    Conserved Domains (1) summary
    pfam04756
    Location:34 → 133
    OST3_OST6; OST3 / OST6 family

  3. NM_021227.4 → NP_067050.1  oligosaccharyltransferase complex subunit OSTC isoform 1

    See identical proteins and their annotated locations for NP_067050.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC054857, BM994257
    Consensus CDS
    CCDS3681.1
    UniProtKB/Swiss-Prot
    A8MYS2, B2R5H1, D6RH22, Q9NRP0, Q9P075, Q9P1R4
    Related
    ENSP00000354676.4, ENST00000361564.9
    Conserved Domains (1) summary
    pfam04756
    Location:17 → 146
    OST3_OST6; OST3 / OST6 family, transporter family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    108650599..108667820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    111953502..111970777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRP0.1 GenPept UniProtKB/Swiss-Prot:Q9NRP0

Gene LinkOut

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