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ZBTB26 zinc finger and BTB domain containing 26 [ Homo sapiens (human) ]

Gene ID: 57684, updated on 5-Mar-2024

Summary

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Official Symbol
ZBTB26provided by HGNC
Official Full Name
zinc finger and BTB domain containing 26provided by HGNC
Primary source
HGNC:HGNC:23383
See related
Ensembl:ENSG00000171448 MIM:620164; AllianceGenome:HGNC:23383
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF481; bioref
Summary
Enables identical protein binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 7.0), ovary (RPKM 4.9) and 25 other tissues See more
Orthologs
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Genomic context

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See ZBTB26 in Genome Data Viewer
Location:
9q33.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (122915566..122931512, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (135112805..135128757, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125677845..125693791, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ring finger and CCCH-type domains 2 Neighboring gene small nucleolar RNA, C/D box 90 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:125677135-125677892 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:125683768-125684268 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:125684269-125684769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20244 Neighboring gene zinc finger and BTB domain containing 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28931 Neighboring gene uncharacterized LOC105379839 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:125703098-125703822 Neighboring gene RAB GTPase activating protein 1 Neighboring gene RNY1 pseudogene 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of ZBTB26 as a Novel Risk Factor for Congenital Hypothyroidism. Vick P, et al. Genes (Basel), 2021 Nov 24. PMID 34946811, Free PMC Article
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Aug 31. PMID 10997877
  3. Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations. Connaughton DM, et al. Am J Hum Genet, 2020 Oct 1. PMID 32891193, Free PMC Article
  4. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
  5. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of ZBTB26 as a Novel Risk Factor for Congenital Hypothyroidism.
    Title: Identification of ZBTB26 as a Novel Risk Factor for Congenital Hypothyroidism.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: ZBTB6

Homology

Clone Names

  • KIAA1572

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 26
Names
zinc finger protein 481
zinc finger protein 483
zinc finger protein Bioref

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304363.2 → NP_001291292.1  zinc finger and BTB domain-containing protein 26

    See identical proteins and their annotated locations for NP_001291292.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC007066, AK058083, BC018748, BM682342, DA212731
    Consensus CDS
    CCDS6847.1
    UniProtKB/Swiss-Prot
    B3KQ53, Q8WTR1, Q9HCK0
    Conserved Domains (5) summary
    COG5236
    Location:269 → 381
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:300 → 320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18214
    Location:8 → 129
    BTB_POZ_ZBTB26_Bioref; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26)
    pfam00096
    Location:298 → 320
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:315 → 337
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001304364.2 → NP_001291293.1  zinc finger and BTB domain-containing protein 26

    See identical proteins and their annotated locations for NP_001291293.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC007066, AK057445, AK058083, BM682342
    Consensus CDS
    CCDS6847.1
    UniProtKB/Swiss-Prot
    B3KQ53, Q8WTR1, Q9HCK0
    Related
    ENSP00000362758.1, ENST00000373654.1
    Conserved Domains (5) summary
    COG5236
    Location:269 → 381
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:300 → 320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18214
    Location:8 → 129
    BTB_POZ_ZBTB26_Bioref; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26)
    pfam00096
    Location:298 → 320
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:315 → 337
    zf-H2C2_2; Zinc-finger double domain

  3. NM_020924.4 → NP_065975.1  zinc finger and BTB domain-containing protein 26

    See identical proteins and their annotated locations for NP_065975.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC007066, AK058083, BC018748, BM682342, HY066289
    Consensus CDS
    CCDS6847.1
    UniProtKB/Swiss-Prot
    B3KQ53, Q8WTR1, Q9HCK0
    Related
    ENSP00000362760.3, ENST00000373656.4
    Conserved Domains (5) summary
    COG5236
    Location:269 → 381
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:300 → 320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18214
    Location:8 → 129
    BTB_POZ_ZBTB26_Bioref; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26)
    pfam00096
    Location:298 → 320
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:315 → 337
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    122915566..122931512 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    135112805..135128757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HCK0.2 GenPept UniProtKB/Swiss-Prot:Q9HCK0

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