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ZBTB2 zinc finger and BTB domain containing 2 [ Homo sapiens (human) ]

Gene ID: 57621, updated on 7-Apr-2024

Summary

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Official Symbol
ZBTB2provided by HGNC
Official Full Name
zinc finger and BTB domain containing 2provided by HGNC
Primary source
HGNC:HGNC:20868
See related
Ensembl:ENSG00000181472 MIM:616595; AllianceGenome:HGNC:20868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF437
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 17.1), lymph node (RPKM 6.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
6q25.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (151364115..151391559, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (152564691..152592145, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (151685250..151712694, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene A-kinase anchoring protein 12 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:151645454-151645654 Neighboring gene RN7SK pseudogene 268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:151662497-151663014 Neighboring gene uncharacterized LOC124901550 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:151675923-151676424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25281 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17685 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17686 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17687 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:151712707-151713579 Neighboring gene uncharacterized LOC124901433 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 15 Neighboring gene required for meiotic nuclear division 1 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness. Koyasu S, et al. EMBO Rep, 2023 Jan 9. PMID 36341521, Free PMC Article
  2. DNA binding of the p21 repressor ZBTB2 is inhibited by cytosine hydroxymethylation. Lafaye C, et al. Biochem Biophys Res Commun, 2014 Mar 28. PMID 24607898
  3. MicroRNA-488-3p inhibits proliferation and induces apoptosis by targeting ZBTB2 in esophageal squamous cell carcinoma. Yang Y, et al. J Cell Biochem, 2019 Nov. PMID 31243806
  4. OIP5-AS1 promotes the progression of gastric cancer cells via the miR-153-3p/ZBTB2 axis. Zhi XH, et al. Eur Rev Med Pharmacol Sci, 2020 Mar. PMID 32196594
  5. MiR-4282 inhibits tumor progression through down-regulation of ZBTB2 by targeting LIN28B in oral squamous cell carcinoma. Zhang Y, et al. J Cell Physiol, 2020 Nov. PMID 31970774

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZBTB2 is Recruited to a Specific Subset of HIF-1 Target Loci to Facilitate Full Gene Expression Under Hypoxia.
    Title: ZBTB2 is Recruited to a Specific Subset of HIF-1 Target Loci to Facilitate Full Gene Expression Under Hypoxia.
  2. ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness.
    Title: ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness.
  3. ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.
    Title: ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.
  4. OIP5-AS1 promotes the progression of gastric cancer cells via the miR-153-3p/ZBTB2 axis.
    Title: OIP5-AS1 promotes the progression of gastric cancer cells via the miR-153-3p/ZBTB2 axis.
  5. MiR-4282 inhibits tumor progression through down-regulation of ZBTB2 by targeting LIN28B in oral squamous cell carcinoma.
    Title: MiR-4282 inhibits tumor progression through down-regulation of ZBTB2 by targeting LIN28B in oral squamous cell carcinoma.
  6. MicroRNA-488-3p inhibits proliferation and induces apoptosis by targeting ZBTB2 in esophageal squamous cell carcinoma.
    Title: MicroRNA-488-3p inhibits proliferation and induces apoptosis by targeting ZBTB2 in esophageal squamous cell carcinoma.
  7. long noncoding RNA CALML3-AS1 promotes tumorigenesis of bladder cancer via regulating ZBTB2 by suppression of microRNA-4316
    Title: LncRNA CALML3-AS1 promotes tumorigenesis of bladder cancer via regulating ZBTB2 by suppression of microRNA-4316.
  8. ZBTB2 may increase cell proliferation by reprogramming glucose metabolic pathways to favor glycolysis by upregulating PDK4 expression via repression of RelA/p65 expression
    Title: ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65.
  9. ZBTB2 being considered as a multifunctional cell proliferation activator, notably through p21 repression, this work points out new epigenetic processes potentially involved in carcinogenesis.
    Title: DNA binding of the p21 repressor ZBTB2 is inhibited by cytosine hydroxymethylation.
  10. ZBTB2 is a potential proto-oncogenic master control gene of the p53 pathway and, in particular, is a potent transcription repressor of the cell cycle arrest gene p21 by inhibiting p53 and Sp1
    Title: ZBTB2, a novel master regulator of the p53 pathway.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of zinc finger and BTB domain containing 2 (ZBTB2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020861.3 → NP_065912.1  zinc finger and BTB domain-containing protein 2

    See identical proteins and their annotated locations for NP_065912.1

    Status: VALIDATED

    Source sequence(s)
    AK291942, BC020172
    Consensus CDS
    CCDS5231.1
    UniProtKB/Swiss-Prot
    A8K7C7, Q5SZ81, Q8N680, Q9P245
    UniProtKB/TrEMBL
    Q658W5
    Related
    ENSP00000323183.4, ENST00000325144.5
    Conserved Domains (4) summary
    sd00017
    Location:365 → 385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:363 → 385
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14 → 84
    BTB; BTB/POZ domain
    pfam13465
    Location:377 → 399
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    151364115..151391559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267076.4 → XP_005267133.1  zinc finger and BTB domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005267133.1

    UniProtKB/Swiss-Prot
    A8K7C7, Q5SZ81, Q8N680, Q9P245
    UniProtKB/TrEMBL
    Q658W5
    Conserved Domains (4) summary
    sd00017
    Location:365 → 385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:363 → 385
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14 → 84
    BTB; BTB/POZ domain
    pfam13465
    Location:377 → 399
    zf-H2C2_2; Zinc-finger double domain

  2. XM_011536004.3 → XP_011534306.1  zinc finger and BTB domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011534306.1

    UniProtKB/Swiss-Prot
    A8K7C7, Q5SZ81, Q8N680, Q9P245
    UniProtKB/TrEMBL
    Q658W5
    Conserved Domains (4) summary
    sd00017
    Location:365 → 385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:363 → 385
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14 → 84
    BTB; BTB/POZ domain
    pfam13465
    Location:377 → 399
    zf-H2C2_2; Zinc-finger double domain

  3. XM_047419188.1 → XP_047275144.1  zinc finger and BTB domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A8K7C7, Q5SZ81, Q8N680, Q9P245

  4. XM_047419189.1 → XP_047275145.1  zinc finger and BTB domain-containing protein 2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    152564691..152592145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356106.1 → XP_054212081.1  zinc finger and BTB domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A8K7C7, Q5SZ81, Q8N680, Q9P245

  2. XM_054356107.1 → XP_054212082.1  zinc finger and BTB domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A8K7C7, Q5SZ81, Q8N680, Q9P245

  3. XM_054356108.1 → XP_054212083.1  zinc finger and BTB domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A8K7C7, Q5SZ81, Q8N680, Q9P245

  4. XM_054356109.1 → XP_054212084.1  zinc finger and BTB domain-containing protein 2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N680.1 GenPept UniProtKB/Swiss-Prot:Q8N680

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