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XPO5 exportin 5 [ Homo sapiens (human) ]

Gene ID: 57510, updated on 7-Apr-2024

Summary

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Official Symbol
XPO5provided by HGNC
Official Full Name
exportin 5provided by HGNC
Primary source
HGNC:HGNC:17675
See related
Ensembl:ENSG00000124571 MIM:607845; AllianceGenome:HGNC:17675
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
exp5
Summary
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]
Expression
Broad expression in testis (RPKM 18.4), thyroid (RPKM 10.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See XPO5 in Genome Data Viewer
Location:
6p21.1
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43522334..43576038, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (43351073..43404771, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43490072..43543775, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24602 Neighboring gene MPRA-validated peak5815 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17235 Neighboring gene U7 small nuclear RNA Neighboring gene small Cajal body-specific RNA 15 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:43514706-43515905 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24603 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43545520-43546020 Neighboring gene leucine rich repeat containing 73 Neighboring gene RNA polymerase I and III subunit C Neighboring gene ribosomal protein S2 pseudogene 29 Neighboring gene Yip1 domain family member 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:43579698-43579923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24605 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17237 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43604555-43605342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43605343-43606129 Neighboring gene MAD2L1 binding protein Neighboring gene DNA polymerase eta Neighboring gene GTP binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mutation in XPO5 causes adult-onset autosomal dominant familial focal segmental glomerulosclerosis. Hussain HMJ, et al. Hum Genomics, 2022 Nov 12. PMID 36371311, Free PMC Article
  2. Selectivity of Exportin 5 binding to human precursor microRNAs. Zhang X, et al. RNA Biol, 2021 Nov 12. PMID 34592896, Free PMC Article
  3. Effects of Knockdown of XPO5 by siRNA on the Biological Behavior of Head and Neck Cancer Cells. Özdaş S, et al. Laryngoscope, 2022 Mar. PMID 34328643
  4. Exportin-5 SUMOylation promotes hepatocellular carcinoma progression. Lin D, et al. Exp Cell Res, 2020 Oct 15. PMID 32763246
  5. Association between XPO5 rs11077 polymorphism and cancer susceptibility: a meta-analysis of 7284 cases and 8511 controls. Moazeni-Roodi A, et al. Exp Oncol, 2019 Dec. PMID 31868332

See all (162) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis through interacting with nuclear export protein XPO5.
    Title: Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis through interacting with nuclear export protein XPO5.
  2. Investigation of the association of the RAN (rs14035) and XPO5 (rs11077) polymorphisms with venous thromboembolism.
    Title: Investigation of the association of the RAN (rs14035) and XPO5 (rs11077) polymorphisms with venous thromboembolism.
  3. Amyotrophic Lateral Sclerosis-Associated Mutants of SOD1 Modulate miRNA Biogenesis through Aberrant Interactions with Exportin 5.
    Title: Amyotrophic Lateral Sclerosis-Associated Mutants of SOD1 Modulate miRNA Biogenesis through Aberrant Interactions with Exportin 5.
  4. Mutation in XPO5 causes adult-onset autosomal dominant familial focal segmental glomerulosclerosis.
    Title: Mutation in XPO5 causes adult-onset autosomal dominant familial focal segmental glomerulosclerosis.
  5. The impact of Dicer, Drosha, and Exportin-5 levels in polycystic ovary syndrome (PCOS) diagnosis and phenotyping.
    Title: The impact of Dicer, Drosha, and Exportin-5 levels in polycystic ovary syndrome (PCOS) diagnosis and phenotyping.
  6. Effects of Knockdown of XPO5 by siRNA on the Biological Behavior of Head and Neck Cancer Cells.
    Title: Effects of Knockdown of XPO5 by siRNA on the Biological Behavior of Head and Neck Cancer Cells.
  7. Selectivity of Exportin 5 binding to human precursor microRNAs.
    Title: Selectivity of Exportin 5 binding to human precursor microRNAs.
  8. Analysis of microRNA processing machinery gene (DROSHA, DICER1, RAN, and XPO5) variants association with end-stage renal disease.
    Title: Analysis of microRNA processing machinery gene (DROSHA, DICER1, RAN, and XPO5) variants association with end-stage renal disease.
  9. Association between Genetic Polymorphisms in microRNA Machinery Genes and Risk of Papillary Thyroid Carcinoma.
    Title: Association between Genetic Polymorphisms in microRNA Machinery Genes and Risk of Papillary Thyroid Carcinoma.
  10. Exportin-5 SUMOylation promotes hepatocellular carcinoma progression.
    Title: Exportin-5 SUMOylation promotes hepatocellular carcinoma progression.
Submit: New GeneRIF Correction See all GeneRIFs (49)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with exportin 5 (XPO5) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14239, FLJ32057, FLJ45606, KIAA1291

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RISC complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding TAS
Traceable Author Statement
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear export signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear export signal receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to pre-miRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pre-miRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pre-miRNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in miRNA metabolic process TAS
Traceable Author Statement
more info
  
involved_in pre-miRNA export from nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pre-miRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pre-miRNA export from nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein export from nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of RISC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA nuclear export complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA nuclear export complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
exportin-5
Names
ran-binding protein 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051658.1 RefSeqGene

    Range
    5038..58742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020750.3 → NP_065801.1  exportin-5

    See identical proteins and their annotated locations for NP_065801.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AB033117, AF298880, BF108994, DB068849
    Consensus CDS
    CCDS47430.1
    UniProtKB/Swiss-Prot
    Q5JTE6, Q96G48, Q96HN3, Q9BWM6, Q9BZV5, Q9H9M4, Q9HAV4, Q9NT89, Q9NW39, Q9ULC9
    UniProtKB/TrEMBL
    A8K5Y7
    Related
    ENSP00000265351.7, ENST00000265351.12

RNA

  1. NR_144392.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL355802, KF458158, KF510953

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    43522334..43576038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    43351073..43404771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HAV4.1 GenPept UniProtKB/Swiss-Prot:Q9HAV4

Gene LinkOut

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