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MAVS mitochondrial antiviral signaling protein [ Homo sapiens (human) ]

Gene ID: 57506, updated on 7-Apr-2024

Summary

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Official Symbol
MAVSprovided by HGNC
Official Full Name
mitochondrial antiviral signaling proteinprovided by HGNC
Primary source
HGNC:HGNC:29233
See related
Ensembl:ENSG00000088888 MIM:609676; AllianceGenome:HGNC:29233
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IPS1; VISA; IPS-1; CARDIF
Summary
This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral innate immunity. [provided by RefSeq, Jul 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in colon (RPKM 9.9), fat (RPKM 9.0) and 25 other tissues See more
Orthologs
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Genomic context

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See MAVS in Genome Data Viewer
Location:
20p13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (3846834..3876118)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (3877778..3907055)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3827481..3856765)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:3791796-3792995 Neighboring gene long intergenic non-protein coding RNA 1730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12631 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:3800994-3801697 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:3811623-3812123 Neighboring gene adaptor related protein complex 5 subunit sigma 1 Neighboring gene NFE2L2 motif-containing MPRA enhancer 155/156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17487 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12633 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:3831491-3831992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3838319-3838818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3846659-3847160 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:3869109-3869660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12635 Neighboring gene PANK2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 6416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17488 Neighboring gene pantothenate kinase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3886163-3886663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17489 Neighboring gene microRNA 103a-2 Neighboring gene microRNA 103b-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. O-Linked N-Acetylglucosamine Modification of Mitochondrial Antiviral Signaling Protein Regulates Antiviral Signaling by Modulating Its Activity. Seo J, et al. Front Immunol, 2020. PMID 33603735, Free PMC Article
  2. Suppression of innate immune signaling molecule, MAVS, reduces radiation-induced bystander effect. Jia R, et al. Int J Radiat Biol, 2021. PMID 32776819
  3. MAVS Genetic Variation Is Associated with Decreased HIV-1 Replication In Vitro and Reduced CD4(+) T Cell Infection in HIV-1-Infected Individuals. Stunnenberg M, et al. Viruses, 2020 Jul 16. PMID 32708557, Free PMC Article
  4. The Reduced Oligomerization of MAVS Mediated by ROS Enhances the Cellular Radioresistance. Du Y, et al. Oxid Med Cell Longev, 2020. PMID 32190169, Free PMC Article
  5. Virus Infection Triggers MAVS Polymers of Distinct Molecular Weight. Zamorano Cuervo N, et al. Viruses, 2018 Jan 30. PMID 29385716, Free PMC Article

See all (362) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation.
    Title: The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation.
  2. MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation.
    Title: MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation.
  3. Dengue Virus 2 NS2B Targets MAVS and IKKepsilon to Evade the Antiviral Innate Immune Response.
    Title: Dengue Virus 2 NS2B Targets MAVS and IKKε to Evade the Antiviral Innate Immune Response.
  4. CircPVT1 promotes ER-positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS.
    Title: CircPVT1 promotes ER-positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS.
  5. Retinoic acid-inducible gene 1 (RIG-1) and IFN-beta promoter stimulator-1 (IPS-1) significantly down-regulated in the severe coronavirus disease 2019 (COVID-19).
    Title: Retinoic acid-inducible gene 1 (RIG-1) and IFN-β promoter stimulator-1 (IPS-1) significantly down-regulated in the severe coronavirus disease 2019 (COVID-19).
  6. The effects of NLRP3 and MAVS gene polymorphisms on the risk of asthma: A case-control study.
    Title: The effects of NLRP3 and MAVS gene polymorphisms on the risk of asthma: A case-control study.
  7. RNA binding by ADAR3 inhibits adenosine-to-inosine editing and promotes expression of immune response protein MAVS.
    Title: RNA binding by ADAR3 inhibits adenosine-to-inosine editing and promotes expression of immune response protein MAVS.
  8. The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation.
    Title: The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation.
  9. Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.
    Title: Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.
  10. A conventional immune regulator mitochondrial antiviral signaling protein blocks hepatic steatosis by maintaining mitochondrial homeostasis.
    Title: A conventional immune regulator mitochondrial antiviral signaling protein blocks hepatic steatosis by maintaining mitochondrial homeostasis.
Submit: New GeneRIF Correction See all GeneRIFs (190)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef (NL4-3) degrades (leads to degradation of) MAVS PubMed
nef HIV-1 Nef (NL4-3) blocks MAVS (IPS-1) induced antiviral signalling (IFN release) of host cell (CEM) PubMed
Vpu vpu HIV-1 Vpu (NL4-3) degrades (leads to degradation of) MAVS PubMed
vpu HIV-1 Vpu (NL4-3) blocks MAVS (IPS-1) induced antiviral signalling (IFN release) of host cell (CEM) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: AP5S1

Homology

Clone Names

  • MGC3260, FLJ27482, FLJ31698, FLJ35386, FLJ38051, FLJ41962, KIAA1271, DKFZp547C224, DKFZp666M015

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables CARD domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RIG-I binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular condensate scaffold activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in activation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in antiviral innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasmic pattern recognition receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to virus NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_positive_effect innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of IP-10 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of NLRP3 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction HMP PubMed 
involved_in positive regulation of chemokine (C-C motif) ligand 5 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of defense response to virus by host IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interferon-alpha production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interferon-alpha production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of myeloid dendritic cell cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of response to cytokine stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of type I interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of peroxisome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
  
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial antiviral-signaling protein
Names
CARD adapter inducing interferon beta
CARD adaptor inducing IFN-beta
IFN-B promoter stimulator 1
interferon beta promoter stimulator protein 1
putative NF-kappa-B-activating protein 031N
virus-induced signaling adaptor
virus-induced-signaling adapter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030028.1 RefSeqGene

    Range
    5036..34320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206491.2 → NP_001193420.1  mitochondrial antiviral-signaling protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL109804, AL353194
    Consensus CDS
    CCDS56176.1
    UniProtKB/Swiss-Prot
    Q7Z434
    Related
    ENSP00000413749.2, ENST00000416600.6
    Conserved Domains (1) summary
    PRK07003
    Location:92 → 265
    PRK07003; DNA polymerase III subunit gamma/tau

  2. NM_001385663.1 → NP_001372592.1  mitochondrial antiviral-signaling protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL109804, AL353194
    Consensus CDS
    CCDS56176.1
    Conserved Domains (1) summary
    PRK07003
    Location:92 → 265
    PRK07003; DNA polymerase III subunit gamma/tau

  3. NM_020746.5 → NP_065797.2  mitochondrial antiviral-signaling protein isoform 1

    See identical proteins and their annotated locations for NP_065797.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL353194, BC044952, DB219666, DQ167126
    Consensus CDS
    CCDS33437.1
    UniProtKB/Swiss-Prot
    A8K6X0, B2BD33, B2BD34, F5H6C8, M1P2Z0, Q2HWT5, Q3I0Y2, Q5T7I6, Q7Z434, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9
    Related
    ENSP00000401980.2, ENST00000428216.4
    Conserved Domains (1) summary
    cd08811
    Location:3 → 93
    CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1

RNA

  1. NR_037921.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL353194, DB219666, EF467324

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    3846834..3876118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    3877778..3907055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z434.2 GenPept UniProtKB/Swiss-Prot:Q7Z434

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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