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MIF4GD MIF4G domain containing [ Homo sapiens (human) ]

Gene ID: 57409, updated on 3-Apr-2024

Summary

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Official Symbol
MIF4GDprovided by HGNC
Official Full Name
MIF4G domain containingprovided by HGNC
Primary source
HGNC:HGNC:24030
See related
Ensembl:ENSG00000125457 MIM:612072; AllianceGenome:HGNC:24030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIFD; AD023; SLIP1
Summary
This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in lymph node (RPKM 9.4), bone marrow (RPKM 8.3) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
17q25.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (75266228..75271292, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (76158321..76163378, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73262309..73267373, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:73201514-73202447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73203873-73204440 Neighboring gene nucleoporin 85 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73220785-73221286 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:73221550-73222749 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73230746-73230909 Neighboring gene Sharpr-MPRA regulatory region 15557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12738 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12740 Neighboring gene Sharpr-MPRA regulatory region 8279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12741 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73257869-73258746 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8960 Neighboring gene mitochondrial ribosomal protein S7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8961 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73268227-73269014 Neighboring gene MIF4GD divergent transcript Neighboring gene solute carrier family 25 member 19 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:73284659-73285160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8963 Neighboring gene uncharacterized LOC124904059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12750

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MIF4G domain containing protein regulates cell cycle and hepatic carcinogenesis by antagonizing CDK2-dependent p27 stability. Wan C, et al. Oncogene, 2015 Jan 8. PMID 24336329
  2. INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation. Neusiedler J, et al. RNA, 2012 Jun. PMID 22532700, Free PMC Article
  3. SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein. Cakmakci NG, et al. Mol Cell Biol, 2008 Feb. PMID 18025107, Free PMC Article
  4. Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1. Bansal N, et al. Biochemistry, 2013 Jan 22. PMID 23286197, Free PMC Article
  5. Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins. von Moeller H, et al. Nucleic Acids Res, 2013 Sep. PMID 23804756, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that MIF4GD is a potential regulator of p27-dependent cell proliferation in HCC.
    Title: MIF4G domain containing protein regulates cell cycle and hepatic carcinogenesis by antagonizing CDK2-dependent p27 stability.
  2. Data suggest that oligomerization and SLBP phosphorylation regulate SLBP-SLIP1-histone-mRNA complex formation/disassociation; sequential and ordered assembly is required.
    Title: Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1.
  3. This paper describes the oligomeric state of SLIP1 and the SLIP1-SLBP complex and how it is regulated by SLBP phosphorylation. Using alanine scanning mutagenesis, the authors demonstrate that the binding site on SLIP1 for SLBP lies close to the dimer interface. A single-point mutant near the SLIP1 homodimer interface abolished interaction with SLBP in vitro and reduced the abundance of histone mRNA in vivo.
    Title: Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1.
  4. INT6 and MIF4GD were observed to colocalize in cytoplasmic foci. It was concluded that INT6, by establishing interactions with MIF4GD and SLBP, plays an important role in translation of poly(A) minus histone mRNAs.
    Title: INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation.
  5. downregulation of endogenous SLIP1 reduces the rate of translation of endogenous histone mRNA and also reduces cell viability.
    Title: SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC45027

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cap-dependent translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
part_of histone mRNA stem-loop binding complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
MIF4G domain-containing protein
Names
SLBP (stem loop binding protein)-interacting protein 1
SLBP-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242498.2 → NP_001229427.1  MIF4G domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001229427.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variant 6, encodes the longest isoform (1).
    Source sequence(s)
    AC022211, AK300711, BC033759, BI752882
    Consensus CDS
    CCDS58598.1
    UniProtKB/TrEMBL
    A0A0S2Z5S7
    Related
    ENSP00000462459.1, ENST00000579297.5
    Conserved Domains (1) summary
    cl02652
    Location:75 → 220
    MIF4G; MIF4G domain

  2. NM_001242500.1 → NP_001229429.1  MIF4G domain-containing protein isoform 2

    See identical proteins and their annotated locations for NP_001229429.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variant 2, encodes isoform (2).
    Source sequence(s)
    AC022211, BC033759, BU190758
    Consensus CDS
    CCDS11719.1
    UniProtKB/TrEMBL
    A0A0S2Z5T5
    Conserved Domains (1) summary
    cl02652
    Location:68 → 213
    MIF4G; MIF4G domain

  3. NM_001242501.1 → NP_001229430.1  MIF4G domain-containing protein isoform 4

    See identical proteins and their annotated locations for NP_001229430.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 7-10, encodes isoform (4).
    Source sequence(s)
    BC033759, CA488406
    Consensus CDS
    CCDS56044.1
    UniProtKB/Swiss-Prot
    A9UHW6, B4DUM7, Q8N4Q5, Q9HBL5
    UniProtKB/TrEMBL
    A0A0S2Z5K9, J3QRZ6
    Related
    ENSP00000484245.1, ENST00000618645.5
    Conserved Domains (1) summary
    cl02652
    Location:8 → 179
    MIF4G; MIF4G domain

  4. NM_001363806.2 → NP_001350735.1  MIF4G domain-containing protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022211
    Consensus CDS
    CCDS92390.1
    UniProtKB/TrEMBL
    J3KSB8
    Related
    ENSP00000462412.1, ENST00000580571.5

  5. NM_001365751.1 → NP_001352680.1  MIF4G domain-containing protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 1, encodes the longest isoform (1).
    Source sequence(s)
    AC022211
    Consensus CDS
    CCDS58598.1
    UniProtKB/TrEMBL
    A0A0S2Z5S7
    Conserved Domains (1) summary
    cl02652
    Location:75 → 220
    MIF4G; MIF4G domain

  6. NM_001365752.1 → NP_001352681.1  MIF4G domain-containing protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 4 and 8-10, encodes isoform (4).
    Source sequence(s)
    AC022211
    Consensus CDS
    CCDS56044.1
    UniProtKB/Swiss-Prot
    A9UHW6, B4DUM7, Q8N4Q5, Q9HBL5
    UniProtKB/TrEMBL
    A0A0S2Z5K9, J3QRZ6
    Related
    ENSP00000464448.1, ENST00000580717.5
    Conserved Domains (1) summary
    cl02652
    Location:8 → 179
    MIF4G; MIF4G domain

  7. NM_001365753.1 → NP_001352682.1  MIF4G domain-containing protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 4, 7, 9, and 10, encodes isoform (4).
    Source sequence(s)
    AC022211
    Consensus CDS
    CCDS56044.1
    UniProtKB/Swiss-Prot
    A9UHW6, B4DUM7, Q8N4Q5, Q9HBL5
    UniProtKB/TrEMBL
    A0A0S2Z5K9, J3QRZ6
    Conserved Domains (1) summary
    cl02652
    Location:8 → 179
    MIF4G; MIF4G domain

  8. NM_001365754.1 → NP_001352683.1  MIF4G domain-containing protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 4, 7, 8, and 10, encodes isoform (4).
    Source sequence(s)
    AC022211
    Consensus CDS
    CCDS56044.1
    UniProtKB/Swiss-Prot
    A9UHW6, B4DUM7, Q8N4Q5, Q9HBL5
    UniProtKB/TrEMBL
    A0A0S2Z5K9, J3QRZ6
    Conserved Domains (1) summary
    cl02652
    Location:8 → 179
    MIF4G; MIF4G domain

  9. NM_001365755.1 → NP_001352684.1  MIF4G domain-containing protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 4 and 7-9, encodes isoform (4).
    Source sequence(s)
    AC022211
    Consensus CDS
    CCDS56044.1
    UniProtKB/Swiss-Prot
    A9UHW6, B4DUM7, Q8N4Q5, Q9HBL5
    UniProtKB/TrEMBL
    A0A0S2Z5K9, J3QRZ6
    Conserved Domains (1) summary
    cl02652
    Location:8 → 179
    MIF4G; MIF4G domain

  10. NM_001370592.1 → NP_001357521.1  MIF4G domain-containing protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC022211, AF225422, BP308696
    Consensus CDS
    CCDS56044.1
    UniProtKB/Swiss-Prot
    A9UHW6, B4DUM7, Q8N4Q5, Q9HBL5
    UniProtKB/TrEMBL
    A0A0S2Z5K9, J3QRZ6
    Related
    ENSP00000321625.8, ENST00000325102.13
    Conserved Domains (1) summary
    cl02652
    Location:8 → 179
    MIF4G; MIF4G domain

  11. NM_001411093.1 → NP_001398022.1  MIF4G domain-containing protein isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC022211
    Consensus CDS
    CCDS92391.1
    UniProtKB/TrEMBL
    J3QLJ5

  12. NM_020679.4 → NP_065730.2  MIF4G domain-containing protein isoform 2

    See identical proteins and their annotated locations for NP_065730.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variant 3, encodes isoform (2).
    Source sequence(s)
    AC022211, BC033759, BI752882, BX404175
    Consensus CDS
    CCDS11719.1
    UniProtKB/TrEMBL
    A0A0S2Z5T5
    Related
    ENSP00000245551.5, ENST00000245551.9
    Conserved Domains (1) summary
    cl02652
    Location:68 → 213
    MIF4G; MIF4G domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    75266228..75271292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436457.1 → XP_047292413.1  MIF4G domain-containing protein isoform X6

  2. XM_047436452.1 → XP_047292408.1  MIF4G domain-containing protein isoform X4

    UniProtKB/TrEMBL
    J3QLJ5
    Related
    ENSP00000463579.1, ENST00000579119.5

  3. XM_047436454.1 → XP_047292410.1  MIF4G domain-containing protein isoform X9

  4. XM_047436448.1 → XP_047292404.1  MIF4G domain-containing protein isoform X2

  5. XM_047436455.1 → XP_047292411.1  MIF4G domain-containing protein isoform X5

  6. XM_047436444.1 → XP_047292400.1  MIF4G domain-containing protein isoform X1

  7. XM_047436458.1 → XP_047292414.1  MIF4G domain-containing protein isoform X8

    UniProtKB/TrEMBL
    J3KSB8

  8. XM_047436456.1 → XP_047292412.1  MIF4G domain-containing protein isoform X10

  9. XM_047436450.1 → XP_047292406.1  MIF4G domain-containing protein isoform X7

    UniProtKB/TrEMBL
    A0A0S2Z5S7
    Related
    ENSP00000463334.1, ENST00000577542.5

  10. XM_047436445.1 → XP_047292401.1  MIF4G domain-containing protein isoform X1

  11. XM_047436447.1 → XP_047292403.1  MIF4G domain-containing protein isoform X1

  12. XM_011525055.3 → XP_011523357.2  MIF4G domain-containing protein isoform X8

    UniProtKB/TrEMBL
    J3KSB8

  13. XM_047436449.1 → XP_047292405.1  MIF4G domain-containing protein isoform X6

  14. XM_047436443.1 → XP_047292399.1  MIF4G domain-containing protein isoform X4

    UniProtKB/TrEMBL
    J3QLJ5

  15. XM_011525052.3 → XP_011523354.2  MIF4G domain-containing protein isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z5T5

  16. XM_047436442.1 → XP_047292398.1  MIF4G domain-containing protein isoform X2

  17. XM_011525054.3 → XP_011523356.2  MIF4G domain-containing protein isoform X5

  18. XM_047436441.1 → XP_047292397.1  MIF4G domain-containing protein isoform X1

  19. XM_047436451.1 → XP_047292407.1  MIF4G domain-containing protein isoform X7

    UniProtKB/TrEMBL
    A0A0S2Z5S7
    Related
    ENSP00000462655.2, ENST00000579194.6

  20. XM_047436446.1 → XP_047292402.1  MIF4G domain-containing protein isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    76158321..76163378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316743.1 → XP_054172718.1  MIF4G domain-containing protein isoform X6

  2. XM_054316738.1 → XP_054172713.1  MIF4G domain-containing protein isoform X4

    UniProtKB/TrEMBL
    J3QLJ5

  3. XM_054316740.1 → XP_054172715.1  MIF4G domain-containing protein isoform X9

  4. XM_054316733.1 → XP_054172708.1  MIF4G domain-containing protein isoform X2

  5. XM_054316741.1 → XP_054172716.1  MIF4G domain-containing protein isoform X5

  6. XM_054316729.1 → XP_054172704.1  MIF4G domain-containing protein isoform X1

  7. XM_054316744.1 → XP_054172719.1  MIF4G domain-containing protein isoform X8

    UniProtKB/TrEMBL
    J3KSB8

  8. XM_054316742.1 → XP_054172717.1  MIF4G domain-containing protein isoform X10

  9. XM_054316736.1 → XP_054172711.1  MIF4G domain-containing protein isoform X7

    UniProtKB/TrEMBL
    A0A0S2Z5S7

  10. XM_054316730.1 → XP_054172705.1  MIF4G domain-containing protein isoform X1

  11. XM_054316732.1 → XP_054172707.1  MIF4G domain-containing protein isoform X1

  12. XM_054316739.1 → XP_054172714.1  MIF4G domain-containing protein isoform X8

    UniProtKB/TrEMBL
    J3KSB8

  13. XM_054316735.1 → XP_054172710.1  MIF4G domain-containing protein isoform X6

  14. XM_054316728.1 → XP_054172703.1  MIF4G domain-containing protein isoform X4

    UniProtKB/TrEMBL
    J3QLJ5

  15. XM_054316727.1 → XP_054172702.1  MIF4G domain-containing protein isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z5T5

  16. XM_054316726.1 → XP_054172701.1  MIF4G domain-containing protein isoform X2

  17. XM_054316734.1 → XP_054172709.1  MIF4G domain-containing protein isoform X5

  18. XM_054316725.1 → XP_054172700.1  MIF4G domain-containing protein isoform X1

  19. XM_054316737.1 → XP_054172712.1  MIF4G domain-containing protein isoform X7

    UniProtKB/TrEMBL
    A0A0S2Z5S7

  20. XM_054316731.1 → XP_054172706.1  MIF4G domain-containing protein isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A9UHW6.1 GenPept UniProtKB/Swiss-Prot:A9UHW6

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