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CAMK1G calcium/calmodulin dependent protein kinase IG [ Homo sapiens (human) ]

Gene ID: 57172, updated on 3-Apr-2024

Summary

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Official Symbol
CAMK1Gprovided by HGNC
Official Full Name
calcium/calmodulin dependent protein kinase IGprovided by HGNC
Primary source
HGNC:HGNC:14585
See related
Ensembl:ENSG00000008118 MIM:614994; AllianceGenome:HGNC:14585
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VWS1; CLICK3; CLICKIII
Summary
Predicted to enable calmodulin binding activity and calmodulin-dependent protein kinase activity. Predicted to be involved in peptidyl-serine phosphorylation. Predicted to be located in endomembrane system. Predicted to be part of calcium- and calmodulin-dependent protein kinase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary (RPKM 11.3), brain (RPKM 11.2) and 5 other tissues See more
Orthologs
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Genomic context

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Location:
1q32.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (209583714..209613939)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (208830506..208860706)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (209757059..209787284)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372898 Neighboring gene MPRA-validated peak673 silencer Neighboring gene uncharacterized LOC105372899 Neighboring gene uncharacterized LOC107985256 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:209781202-209781360 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:209782479-209783678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:209802693-209803194 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:209803195-209803696 Neighboring gene laminin subunit beta 3 Neighboring gene microRNA 4260 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:209825272-209826471 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:209830041-209831240 Neighboring gene HSD11B1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2469 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:209848869-209849717 Neighboring gene G0/G1 switch 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. No evidence of association between polymorphisms in four genes and sporadic amyotrophic lateral sclerosis in Han Chinese. An R, et al. Amyotroph Lateral Scler Frontotemporal Degener, 2015 Jun. PMID 25677198
  2. Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis. Deng M, et al. Nat Genet, 2013 Jun. PMID 23624525
  3. Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons. Pang ZP, et al. J Biol Chem, 2010 Oct 29. PMID 20729199, Free PMC Article
  4. Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK). Takemoto-Kimura S, et al. J Biol Chem, 2003 May 16. PMID 12637513
  5. A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41. Schutte BC, et al. Genome Res, 2000 Jan. PMID 10645953, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. No evidence of association between polymorphisms in CAMK1G and sporadic amyotrophic lateral sclerosis in Han Chinese
    Title: No evidence of association between polymorphisms in four genes and sporadic amyotrophic lateral sclerosis in Han Chinese.
  2. Two new susceptibility loci for amyotrophic lateral sclerosis in the Han Chinese population in chromosome 1, CAMK1G and chromosome 22, SUSD2 and CABIN1.
    Title: Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis.
  3. Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons
    Title: Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons.
  4. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  6. CLICK-III/CaMKIgamma is a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK).
    Title: Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK).
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis.
EBI GWAS Catalog
Genome-wide population-based association study of extremely overweight young adults--the GOYA study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
part_of calcium- and calmodulin-dependent protein kinase complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calcium/calmodulin-dependent protein kinase type 1G
Names
caM kinase I gamma
caM kinase IG
caM-KI gamma
caMK-like CREB kinase III
caMKI gamma
caMKIG
NP_065172.1
XP_016857355.1
XP_016857356.1
XP_054193773.1
XP_054193774.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020439.3 → NP_065172.1  calcium/calmodulin-dependent protein kinase type 1G

    See identical proteins and their annotated locations for NP_065172.1

    Status: REVIEWED

    Source sequence(s)
    AL049688, BC032787, BG715920
    Consensus CDS
    CCDS1486.1
    UniProtKB/Swiss-Prot
    Q86UH5, Q96NX5, Q9Y3J7
    UniProtKB/TrEMBL
    B3KTK0
    Related
    ENSP00000354861.2, ENST00000361322.3
    Conserved Domains (1) summary
    cd14166
    Location:19 → 303
    STKc_CaMKI_gamma; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I gamma

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    209583714..209613939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001866.3 → XP_016857355.1  calcium/calmodulin-dependent protein kinase type 1G isoform X1

    UniProtKB/Swiss-Prot
    Q86UH5, Q96NX5, Q9Y3J7
    UniProtKB/TrEMBL
    B3KTK0
    Related
    ENSP00000009105.1, ENST00000009105.5
    Conserved Domains (1) summary
    cd14166
    Location:19 → 303
    STKc_CaMKI_gamma; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I gamma

  2. XM_017001867.2 → XP_016857356.1  calcium/calmodulin-dependent protein kinase type 1G isoform X2

    UniProtKB/TrEMBL
    A0A494C109
    Related
    ENSP00000498823.1, ENST00000651530.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    208830506..208860706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337798.1 → XP_054193773.1  calcium/calmodulin-dependent protein kinase type 1G isoform X1

    UniProtKB/Swiss-Prot
    Q86UH5, Q96NX5, Q9Y3J7

  2. XM_054337799.1 → XP_054193774.1  calcium/calmodulin-dependent protein kinase type 1G isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96NX5.3 GenPept UniProtKB/Swiss-Prot:Q96NX5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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